Association between microRNA-146a, -499a and -196a-2 SNPs and non-small cell lung cancer: a case–control study involving 2249 subjects

• Published in: Bioscience reports Vol. 41; no. 2
• Main Authors: Qiu, Hao, Xie, Zhiqiang, Tang, Weifeng, Liu, Chao, Wang, Yafeng, Gu, Haiyong, Zheng, Qingfeng
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd The Biochemical Society 26.02.2021; Portland Press Ltd
• Subjects: Age; Aged; Body mass index; Body size; Cancer; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Case studies; Case-Control Studies; Cell growth; Cell proliferation; Chemotherapy; DNA, Chromosomes & Chromosomal Structure; Energy metabolism; Female; Females; Gene expression; Genetic Predisposition to Disease; Genetic testing; Humans; Immunology & Inflammation; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; Males; MicroRNAs; MicroRNAs - genetics; Middle Aged; miRNA; Non-small cell lung carcinoma; Nucleotides; Oxidative metabolism; Oxidative stress; Polymorphism; Polymorphism, Single Nucleotide; Ribonucleic acid; Risk factors; Risk reduction; RNA; Single-nucleotide polymorphism; Small cell lung carcinoma; Subgroups; China; non-small cell lung cancer; microRNA; polymorphism; susceptibility

MicroRNA (miR) acts as a negative regulator of gene expression. Many literatures have suggested that miRs may be involved in the process of cell proliferation, inflammation, oxidative stress, energy metabolism and epithelial–mesenchymal transition. Thus, miRs may be implicated in the occurrence of n...