A concise tutorial review of TOF-SIMS based molecular and cellular imaging

This concise tutorial review provides a description of the current state of the art in the application of time-of flight based secondary ion mass spectrometry (TOF-SIMS) in the field of molecular and cellular imaging. The application of TOF-SIMS requires a choice of the appropriate beam combined wit...

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Published inJournal of analytical atomic spectrometry Vol. 34; no. 11; pp. 2217 - 2228
Main Authors Massonnet, Philippe, Heeren, Ron M. A
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 01.11.2019
Subjects
Identification methods
Imaging
Ions
Secondary ion mass spectrometry
Online AccessGet full text
ISSN0267-9477
1364-5544
DOI10.1039/c9ja00164f

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Abstract This concise tutorial review provides a description of the current state of the art in the application of time-of flight based secondary ion mass spectrometry (TOF-SIMS) in the field of molecular and cellular imaging. The application of TOF-SIMS requires a choice of the appropriate beam combined with a signal enhancement method depending on the surface under investigation. The types of detected molecules and methods for molecular identification in SIMS are strongly determined by this combination of ionization method and sample preparation. The use of TOF-SIMS for single cell and three-dimensional imaging will be discussed in the context of selected applications. Finally we will discuss an outlook on the application of the TOF-SIMS technology in a multimodal molecular imaging context. This concise tutorial review provides a description of the current state of the art in the application of time-of flight based secondary ion mass spectrometry (TOF-SIMS) in the field of molecular and cellular imaging.
AbstractList This concise tutorial review provides a description of the current state of the art in the application of time-of flight based secondary ion mass spectrometry (TOF-SIMS) in the field of molecular and cellular imaging. The application of TOF-SIMS requires a choice of the appropriate beam combined with a signal enhancement method depending on the surface under investigation. The types of detected molecules and methods for molecular identification in SIMS are strongly determined by this combination of ionization method and sample preparation. The use of TOF-SIMS for single cell and three-dimensional imaging will be discussed in the context of selected applications. Finally we will discuss an outlook on the application of the TOF-SIMS technology in a multimodal molecular imaging context.
This concise tutorial review provides a description of the current state of the art in the application of time-of flight based secondary ion mass spectrometry (TOF-SIMS) in the field of molecular and cellular imaging. The application of TOF-SIMS requires a choice of the appropriate beam combined with a signal enhancement method depending on the surface under investigation. The types of detected molecules and methods for molecular identification in SIMS are strongly determined by this combination of ionization method and sample preparation. The use of TOF-SIMS for single cell and three-dimensional imaging will be discussed in the context of selected applications. Finally we will discuss an outlook on the application of the TOF-SIMS technology in a multimodal molecular imaging context. This concise tutorial review provides a description of the current state of the art in the application of time-of flight based secondary ion mass spectrometry (TOF-SIMS) in the field of molecular and cellular imaging.
Author Heeren, Ron M. A
Massonnet, Philippe
AuthorAffiliation Maastricht MultiModal Molecular Imaging (M4I) Institute
Maastricht University
AuthorAffiliation_xml – name: Maastricht MultiModal Molecular Imaging (M4I) Institute
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  surname: Massonnet
  fullname: Massonnet, Philippe
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  givenname: Ron M. A
  surname: Heeren
  fullname: Heeren, Ron M. A
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Cites_doi 10.1002/dta.1812
10.1002/sia.3562
10.1021/ja00374a053
10.1021/la800292e
10.1021/ac00185a009
10.1021/acs.analchem.6b01022
10.1007/s00216-013-7048-1
10.1021/jp049936a
10.1021/acs.jpcc.7b02596
10.1002/sia.3203
10.1021/ac900045m
10.1021/ac2032707
10.1021/ac201481r
10.1021/ac0616005
10.1007/s00216-012-6451-3
10.4155/bio.16.11
10.1021/ac00058a021
10.1002/sia.3675
10.1007/s13361-015-1275-y
10.1021/jp9907138
10.1002/sia.5547
10.1021/ar00081a001
10.1016/j.apsusc.2004.03.197
10.1021/acs.analchem.6b04819
10.1021/ac2032589
10.1021/ac1015326
10.1116/1.4907727
10.1007/s13361-014-0927-7
10.1002/sia.5609
10.1016/j.cbpa.2013.07.017
10.1021/ac801591r
10.1016/j.aca.2013.09.004
10.1021/ac048329g
10.1016/j.apsusc.2006.02.266
10.1016/j.ijms.2013.12.012
10.1002/pmic.200800127
10.1021/acs.analchem.8b02950
10.1039/b913575h
10.1364/BOE.6.000559
10.1021/ac00267a062
10.1007/s13361-014-0978-9
10.1016/j.apsusc.2004.03.098
10.1016/j.apsusc.2006.02.169
10.1002/sia.1247
10.1021/ac0302105
10.1021/la001209t
10.1351/pac199567081307
10.1039/C5AN01743B
10.1016/j.ijms.2006.09.029
10.1007/s00216-009-3031-2
10.1021/ac701921e
10.1007/s00401-012-1041-1
10.1021/acs.analchem.5b04133
10.1016/0039-6028(94)90658-0
10.1007/s13361-015-1146-6
10.1194/jlr.M700421-JLR200
10.1016/j.apsusc.2004.03.100
10.1021/ac0481349
10.1016/S0040-4039(99)01158-2
10.1016/j.apsusc.2008.05.139
10.1021/ac026338o
10.1021/ja051223y
10.1021/acs.analchem.7b02573
10.1158/0008-5472.CAN-10-0360
10.1016/S0169-4332(01)00276-8
10.1016/j.bbalip.2014.03.003
10.1002/sia.2361
10.1016/j.apsusc.2004.03.029
10.1016/0039-6028(75)90297-6
10.1021/ac062406l
10.1002/rcm.7210
10.1371/journal.pone.0099319
10.1021/ac402288d
10.1002/pmic.200900782
10.1021/ac9701748
10.1016/j.bbalip.2011.05.007
10.1021/ac049108d
10.1002/rcm.1995
10.1111/j.1475-097X.2008.00796.x
10.1002/jemt.20481
10.1021/ac0513111
10.1016/j.apsusc.2004.03.104
10.1116/1.4942884
10.1116/1.573015
10.1002/sia.3415
10.1116/1.4941009
10.1039/C8JA00425K
10.1002/sia.1438
10.1002/jms.735
10.1021/ac300480g
10.1016/j.orggeochem.2013.01.005
10.1016/S0169-4332(02)00631-1
10.1091/mbc.e13-09-0516
10.1038/nmeth.3296
10.1002/jbm.a.10063
10.1021/jp208035x
10.1016/j.jasms.2006.10.017
10.1103/PhysRevLett.63.1625
10.1021/ac504604g
10.1016/1044-0305(95)00703-2
10.1021/ac303290s
10.1021/ac049389p
10.1002/pmic.200800364
10.1002/sia.5606
10.1038/s41598-019-38914-y
10.1016/j.jprot.2012.03.017
10.1002/mas.20275
10.1021/acs.jpcc.6b08646
10.1016/j.apsusc.2006.02.206
10.1002/sia.5093
10.1111/j.1472-4669.2007.00119.x
10.1021/ac200288v
10.1021/ja071879m
10.1021/ac3019334
10.1016/1044-0305(92)87058-7
10.1021/ac950717i
10.1021/ac026434p
10.1016/j.apsusc.2008.05.007
10.1002/mas.20124
10.1016/j.apsusc.2006.02.142
10.1021/ac202222h
10.1007/s13361-016-1485-y
10.1002/rcm.1342
10.1046/j.1365-2818.2000.00738.x
10.1021/ac053355f
10.1021/ac00289a027
10.1021/acs.analchem.7b04733
10.1002/sia.2233
10.1021/ac5020222
10.1016/j.chroma.2010.01.033
10.1016/0248-4900(92)90007-N
10.1021/la0358419
10.1021/la034081z
10.1002/sia.5055
10.1021/ac504191m
10.1021/acs.analchem.5b03979
10.1021/ac0207675
10.1021/ac020125h
10.1116/1.579185
10.1016/j.febslet.2004.04.052
10.1002/sia.2121
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Notes Dr Philippe Massonnet obtained his M.Sc. degree in Chemistry in 2012 and PhD degree in 2017 at the University of Liège (Belgium). His PhD thesis was performed under the supervision of Prof. De Pauw and Prof. Quinton in the Mass Spectrometry Laboratory and his research focused on the development of new mass spectrometry-based characterization techniques of disulfide-bonded peptides. He is currently a post-doctoral fellow at the Maastricht MultiModal Molecular Imaging (M4I) institute in the mass spectrometry imaging division (Prof. Heeren) at Maastricht University (Netherlands) and his research interest includes SIMS instrumental and method developments for biological sample analysis.
Prof. Dr Ron M. A. Heeren (1965) is a distinguished professor and Limburg Chair at the University of Maastricht. He is the director of the Maastricht MultiModal Molecular Imaging (M4I) Institute and heads the division of imaging mass spectrometry. He has developed innovative approaches towards high spatial resolution and high throughput molecular imaging technologies to study the complexity of interfaces. He has a strong interest in translational molecular imaging for tissue typing in personalized medicine.
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References Rao (C9JA00164F-(cit80)/*[position()=1]) 2012; 84
Macfarlane (C9JA00164F-(cit63)/*[position()=1]) 1982; 15
Kotze (C9JA00164F-(cit101)/*[position()=1]) 2013; 45
Klinkert (C9JA00164F-(cit118)/*[position()=1]) 2014; 362
Xu (C9JA00164F-(cit32)/*[position()=1]) 2004; 231–232
Delcorte (C9JA00164F-(cit51)/*[position()=1]) 2007; 79
Malmberg (C9JA00164F-(cit97)/*[position()=1]) 2007; 70
Kurczy (C9JA00164F-(cit39)/*[position()=1]) 2008; 255
Vanbellingen (C9JA00164F-(cit90)/*[position()=1]) 2015; 29
Altelaar (C9JA00164F-(cit99)/*[position()=1]) 2006; 252
Brison (C9JA00164F-(cit123)/*[position()=1]) 2011; 43
Vaidyanathan (C9JA00164F-(cit129)/*[position()=1]) 2008; 80
Ščupáková (C9JA00164F-(cit146)/*[position()=1]) 2019; 9
Fletcher (C9JA00164F-(cit128)/*[position()=1]) 2011; 30
Eller (C9JA00164F-(cit50)/*[position()=1]) 2018; 90
Tahallah (C9JA00164F-(cit85)/*[position()=1]) 2008; 49
Weibel (C9JA00164F-(cit16)/*[position()=1]) 2003; 75
Piehowski (C9JA00164F-(cit136)/*[position()=1]) 2008; 24
Van de Plas (C9JA00164F-(cit144)/*[position()=1]) 2015; 12
Håkansson (C9JA00164F-(cit64)/*[position()=1]) 1982; 104
Lee (C9JA00164F-(cit79)/*[position()=1]) 2007; 129
Passarelli (C9JA00164F-(cit14)/*[position()=1]) 2013; 17
Enjalbal (C9JA00164F-(cit75)/*[position()=1]) 1999; 40
Touboul (C9JA00164F-(cit13)/*[position()=1]) 2016; 8
Monroe (C9JA00164F-(cit98)/*[position()=1]) 2008; 8
Vanbellingen (C9JA00164F-(cit127)/*[position()=1]) 2016; 27
Sjövall (C9JA00164F-(cit96)/*[position()=1]) 2003; 75
Amantonico (C9JA00164F-(cit2)/*[position()=1]) 2010; 82
Wu (C9JA00164F-(cit42)/*[position()=1]) 1996; 68
Werner (C9JA00164F-(cit12)/*[position()=1]) 1975; 47
Colliver (C9JA00164F-(cit135)/*[position()=1]) 1997; 69
Sheraz née Rabbani (C9JA00164F-(cit24)/*[position()=1]) 2014; 46
Lazar (C9JA00164F-(cit95)/*[position()=1]) 2013; 125
Castro (C9JA00164F-(cit105)/*[position()=1]) 1984; 56
Appelhans (C9JA00164F-(cit28)/*[position()=1]) 1989; 61
Benabdellah (C9JA00164F-(cit89)/*[position()=1]) 2010; 396
Castro (C9JA00164F-(cit106)/*[position()=1]) 1985; 57
Locklear (C9JA00164F-(cit57)/*[position()=1]) 2006; 252
Fornai (C9JA00164F-(cit117)/*[position()=1]) 2012; 404
Konig (C9JA00164F-(cit140)/*[position()=1]) 2000; 200
McArthur (C9JA00164F-(cit58)/*[position()=1]) 2004; 20
Bruinen (C9JA00164F-(cit109)/*[position()=1]) 2017
Alvarez (C9JA00164F-(cit104)/*[position()=1]) 2005; 77
Fisher (C9JA00164F-(cit108)/*[position()=1]) 2016; 88
Piehowski (C9JA00164F-(cit111)/*[position()=1]) 2008; 80
Yokoyama (C9JA00164F-(cit112)/*[position()=1]) 2016; 88
Wu (C9JA00164F-(cit138)/*[position()=1]) 2007; 260
Kollmer (C9JA00164F-(cit22)/*[position()=1]) 2013; 45
Xia (C9JA00164F-(cit72)/*[position()=1]) 2003; 67
Flinders (C9JA00164F-(cit54)/*[position()=1]) 2015; 7
Delcorte (C9JA00164F-(cit44)/*[position()=1]) 2004; 231–232
Seeley (C9JA00164F-(cit114)/*[position()=1]) 2012; 84
Mao (C9JA00164F-(cit131)/*[position()=1]) 2012; 84
Henry (C9JA00164F-(cit70)/*[position()=1]) 2003; 19
Dunham (C9JA00164F-(cit49)/*[position()=1]) 2016; 11
Brison (C9JA00164F-(cit122)/*[position()=1]) 2013; 85
Postawa (C9JA00164F-(cit31)/*[position()=1]) 2004; 108
Ma (C9JA00164F-(cit27)/*[position()=1]) 1994; 12
Lanni (C9JA00164F-(cit6)/*[position()=1]) 2012; 75
Do (C9JA00164F-(cit62)/*[position()=1]) 2017; 89
Winograd (C9JA00164F-(cit30)/*[position()=1]) 2006; 252
Restrepo (C9JA00164F-(cit40)/*[position()=1]) 2010; 42
Hutter (C9JA00164F-(cit119)/*[position()=1]) 2001; 179
Trouillon (C9JA00164F-(cit1)/*[position()=1]) 2013; 85
Rabbani (C9JA00164F-(cit25)/*[position()=1]) 2011; 83
Škrášková (C9JA00164F-(cit88)/*[position()=1]) 2015; 26
Thiel (C9JA00164F-(cit92)/*[position()=1]) 2007; 5
Novikov (C9JA00164F-(cit35)/*[position()=1]) 2005; 19
Arlinghaus (C9JA00164F-(cit77)/*[position()=1]) 2002; 34
Kaletaş (C9JA00164F-(cit137)/*[position()=1]) 2009; 9
Lanni (C9JA00164F-(cit15)/*[position()=1]) 2014; 25
Kim (C9JA00164F-(cit73)/*[position()=1]) 2007; 79
Hill (C9JA00164F-(cit116)/*[position()=1]) 2011; 43
McDonnell (C9JA00164F-(cit60)/*[position()=1]) 2005; 40
Robinson (C9JA00164F-(cit130)/*[position()=1]) 2012; 84
Heile (C9JA00164F-(cit38)/*[position()=1]) 2008; 255
Amstalden Van Hove (C9JA00164F-(cit142)/*[position()=1]) 2010; 70
Johansson (C9JA00164F-(cit91)/*[position()=1]) 2006; 38
Benninghoven (C9JA00164F-(cit78)/*[position()=1]) 1985; 3
Buchberger (C9JA00164F-(cit139)/*[position()=1]) 2018; 90
Fletcher (C9JA00164F-(cit5)/*[position()=1]) 2009; 134
Kraft (C9JA00164F-(cit84)/*[position()=1]) 2014; 1841
Mahoney (C9JA00164F-(cit36)/*[position()=1]) 1992; 3
Phan (C9JA00164F-(cit87)/*[position()=1]) 2014; 46
Blain (C9JA00164F-(cit29)/*[position()=1]) 1989; 63
Walsh (C9JA00164F-(cit141)/*[position()=1]) 2015; 6
Tarolli (C9JA00164F-(cit145)/*[position()=1]) 2014; 25
Cheng (C9JA00164F-(cit19)/*[position()=1]) 2007; 18
Lanni (C9JA00164F-(cit143)/*[position()=1]) 2014; 86
Sheraz née Rabbani (C9JA00164F-(cit23)/*[position()=1]) 2015; 87
Brüning (C9JA00164F-(cit71)/*[position()=1]) 2006; 38
Klepárník (C9JA00164F-(cit3)/*[position()=1]) 2013; 800
Miyayama (C9JA00164F-(cit124)/*[position()=1]) 2010; 42
Fletcher (C9JA00164F-(cit121)/*[position()=1]) 2007; 187
Magnusson (C9JA00164F-(cit94)/*[position()=1]) 2008; 28
Weibel (C9JA00164F-(cit17)/*[position()=1]) 2004; 231–232
Mantus (C9JA00164F-(cit68)/*[position()=1]) 1993; 65
Wagner (C9JA00164F-(cit69)/*[position()=1]) 2001; 17
Davies (C9JA00164F-(cit18)/*[position()=1]) 2003; 203–204
Monroe (C9JA00164F-(cit100)/*[position()=1]) 2005; 127
Inoue (C9JA00164F-(cit41)/*[position()=1]) 2006; 252
Moss (C9JA00164F-(cit81)/*[position()=1]) 1995; 67
Tempez (C9JA00164F-(cit34)/*[position()=1]) 2004; 18
Muramoto (C9JA00164F-(cit67)/*[position()=1]) 2011; 115
Delcorte (C9JA00164F-(cit47)/*[position()=1]) 2003; 75
Nygren (C9JA00164F-(cit76)/*[position()=1]) 2010; 10
Vickerman (C9JA00164F-(cit8)/*[position()=1]) 2001
Winograd (C9JA00164F-(cit26)/*[position()=1]) 2005; 77
Alnajeebi (C9JA00164F-(cit33)/*[position()=1]) 2016; 11
Amstalden van Hove (C9JA00164F-(cit7)/*[position()=1]) 2010; 1217
Altelaar (C9JA00164F-(cit43)/*[position()=1]) 2005; 78
Sanni (C9JA00164F-(cit65)/*[position()=1]) 2002; 33
Muro (C9JA00164F-(cit82)/*[position()=1]) 2014; 25
McDonnell (C9JA00164F-(cit9)/*[position()=1]) 2007; 26
Seah (C9JA00164F-(cit132)/*[position()=1]) 2016; 120
Mohammadi (C9JA00164F-(cit53)/*[position()=1]) 2014; 46
Breuer (C9JA00164F-(cit133)/*[position()=1]) 2017; 121
Maharrey (C9JA00164F-(cit103)/*[position()=1]) 2004; 231–232
Castellanos (C9JA00164F-(cit125)/*[position()=1]) 2019; 34
Ogrinc Potočnik (C9JA00164F-(cit74)/*[position()=1]) 2017; 89
Passarelli (C9JA00164F-(cit83)/*[position()=1]) 2011; 1811
Nygren (C9JA00164F-(cit45)/*[position()=1]) 2004; 566
Van Nuffel (C9JA00164F-(cit120)/*[position()=1]) 2016; 141
DeBord (C9JA00164F-(cit107)/*[position()=1]) 2014; 9
Wagner (C9JA00164F-(cit66)/*[position()=1]) 2004; 231–232
Fernandez-Lima (C9JA00164F-(cit20)/*[position()=1]) 2011; 83
Palmer (C9JA00164F-(cit113)/*[position()=1]) 2015; 87
Smith (C9JA00164F-(cit102)/*[position()=1]) 2013; 405
Fletcher (C9JA00164F-(cit115)/*[position()=1]) 2015; 10
Luxembourg (C9JA00164F-(cit59)/*[position()=1]) 2003; 75
Townes (C9JA00164F-(cit21)/*[position()=1]) 1999; 103
Leefmann (C9JA00164F-(cit134)/*[position()=1]) 2013; 57
Castaing (C9JA00164F-(cit4)/*[position()=1]) 1962; 1
Slodzian (C9JA00164F-(cit11)/*[position()=1]) 1992; 74
Körsgen (C9JA00164F-(cit126)/*[position()=1]) 2016; 27
Inoue (C9JA00164F-(cit48)/*[position()=1]) 2005; 37
Svara (C9JA00164F-(cit56)/*[position()=1]) 2011; 83
Benninghoven (C9JA00164F-(cit10)/*[position()=1]) 1994; 299–300
Wang (C9JA00164F-(cit37)/*[position()=1]) 1996; 7
Sjövall (C9JA00164F-(cit86)/*[position()=1]) 2004; 76
Fisher (C9JA00164F-(cit110)/*[position()=1]) 2016; 34
Delcorte (C9JA00164F-(cit46)/*[position()=1]) 2002; 74
Altelaar (C9JA00164F-(cit61)/*[position()=1]) 2005; 77
Debois (C9JA00164F-(cit93)/*[position()=1]) 2009; 81
Cuypers (C9JA00164F-(cit55)/*[position()=1]) 2016; 88
Adriaensen (C9JA00164F-(cit52)/*[position()=1]) 2004; 76
References_xml – issn: 2017
  end-page: p 165-173
  publication-title: Imaging Mass Spectrometry: Methods and Protocols, Methods in Molecular Biology
  doi: Bruinen Fisher Heeren
– volume: 7
  start-page: 859
  year: 2015
  ident: C9JA00164F-(cit54)/*[position()=1]
  publication-title: Drug Test. Anal.
  doi: 10.1002/dta.1812
– volume: 43
  start-page: 506
  year: 2011
  ident: C9JA00164F-(cit116)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/sia.3562
– volume: 104
  start-page: 2948
  year: 1982
  ident: C9JA00164F-(cit64)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja00374a053
– volume: 24
  start-page: 7906
  year: 2008
  ident: C9JA00164F-(cit136)/*[position()=1]
  publication-title: Langmuir
  doi: 10.1021/la800292e
– volume: 61
  start-page: 1087
  year: 1989
  ident: C9JA00164F-(cit28)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac00185a009
– volume: 88
  start-page: 6433
  year: 2016
  ident: C9JA00164F-(cit108)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.6b01022
– volume: 405
  start-page: 6069
  year: 2013
  ident: C9JA00164F-(cit102)/*[position()=1]
  publication-title: Anal. Bioanal. Chem.
  doi: 10.1007/s00216-013-7048-1
– volume: 108
  start-page: 7831
  year: 2004
  ident: C9JA00164F-(cit31)/*[position()=1]
  publication-title: J. Phys. Chem. B
  doi: 10.1021/jp049936a
– volume: 121
  start-page: 19705
  year: 2017
  ident: C9JA00164F-(cit133)/*[position()=1]
  publication-title: J. Phys. Chem. C
  doi: 10.1021/acs.jpcc.7b02596
– volume: 42
  start-page: 1030
  year: 2010
  ident: C9JA00164F-(cit40)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/sia.3203
– volume: 81
  start-page: 2823
  year: 2009
  ident: C9JA00164F-(cit93)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac900045m
– volume: 84
  start-page: 2105
  year: 2012
  ident: C9JA00164F-(cit114)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac2032707
– volume: 83
  start-page: 8448
  year: 2011
  ident: C9JA00164F-(cit20)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac201481r
– volume: 79
  start-page: 1377
  year: 2007
  ident: C9JA00164F-(cit73)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac0616005
– volume-title: Imaging Mass Spectrometry: Methods and Protocols, Methods in Molecular Biology
  year: 2017
  ident: C9JA00164F-(cit109)/*[position()=1]
– volume: 404
  start-page: 2927
  year: 2012
  ident: C9JA00164F-(cit117)/*[position()=1]
  publication-title: Anal. Bioanal. Chem.
  doi: 10.1007/s00216-012-6451-3
– volume: 8
  start-page: 367
  year: 2016
  ident: C9JA00164F-(cit13)/*[position()=1]
  publication-title: Bioanalysis
  doi: 10.4155/bio.16.11
– volume: 65
  start-page: 1431
  year: 1993
  ident: C9JA00164F-(cit68)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac00058a021
– volume: 187
  start-page: 89
  year: 2007
  ident: C9JA00164F-(cit121)/*[position()=1]
  publication-title: Anal. Chem.
– volume: 42
  start-page: 1453
  year: 2010
  ident: C9JA00164F-(cit124)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/sia.3675
– volume: 27
  start-page: 277
  year: 2016
  ident: C9JA00164F-(cit126)/*[position()=1]
  publication-title: J. Am. Soc. Mass Spectrom.
  doi: 10.1007/s13361-015-1275-y
– volume: 103
  start-page: 4587
  year: 1999
  ident: C9JA00164F-(cit21)/*[position()=1]
  publication-title: J. Phys. Chem. A
  doi: 10.1021/jp9907138
– volume: 46
  start-page: 123
  year: 2014
  ident: C9JA00164F-(cit87)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/sia.5547
– volume: 15
  start-page: 268
  year: 1982
  ident: C9JA00164F-(cit63)/*[position()=1]
  publication-title: Acc. Chem. Res.
  doi: 10.1021/ar00081a001
– volume: 231–232
  start-page: 972
  year: 2004
  ident: C9JA00164F-(cit103)/*[position()=1]
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/j.apsusc.2004.03.197
– volume: 89
  start-page: 3078
  year: 2017
  ident: C9JA00164F-(cit62)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.6b04819
– volume: 84
  start-page: 3981
  year: 2012
  ident: C9JA00164F-(cit131)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac2032589
– volume: 82
  start-page: 7394
  year: 2010
  ident: C9JA00164F-(cit2)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac1015326
– volume: 10
  start-page: 018902
  year: 2015
  ident: C9JA00164F-(cit115)/*[position()=1]
  publication-title: Biointerphases
  doi: 10.1116/1.4907727
– volume: 25
  start-page: 2154
  year: 2014
  ident: C9JA00164F-(cit145)/*[position()=1]
  publication-title: J. Am. Soc. Mass Spectrom.
  doi: 10.1007/s13361-014-0927-7
– volume: 46
  start-page: 379
  year: 2014
  ident: C9JA00164F-(cit53)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/sia.5609
– volume: 17
  start-page: 854
  year: 2013
  ident: C9JA00164F-(cit14)/*[position()=1]
  publication-title: Curr. Opin. Chem. Biol.
  doi: 10.1016/j.cbpa.2013.07.017
– volume: 80
  start-page: 8662
  year: 2008
  ident: C9JA00164F-(cit111)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac801591r
– volume: 800
  start-page: 12
  year: 2013
  ident: C9JA00164F-(cit3)/*[position()=1]
  publication-title: Anal. Chim. Acta
  doi: 10.1016/j.aca.2013.09.004
– volume: 77
  start-page: 735
  year: 2005
  ident: C9JA00164F-(cit61)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac048329g
– volume: 252
  start-page: 6702
  year: 2006
  ident: C9JA00164F-(cit99)/*[position()=1]
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/j.apsusc.2006.02.266
– volume: 362
  start-page: 40
  year: 2014
  ident: C9JA00164F-(cit118)/*[position()=1]
  publication-title: Int. J. Mass Spectrom.
  doi: 10.1016/j.ijms.2013.12.012
– volume: 8
  start-page: 3746
  year: 2008
  ident: C9JA00164F-(cit98)/*[position()=1]
  publication-title: Proteomics
  doi: 10.1002/pmic.200800127
– volume: 90
  start-page: 12692
  year: 2018
  ident: C9JA00164F-(cit50)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.8b02950
– volume: 134
  start-page: 2204
  year: 2009
  ident: C9JA00164F-(cit5)/*[position()=1]
  publication-title: Analyst
  doi: 10.1039/b913575h
– volume: 6
  start-page: 559
  year: 2015
  ident: C9JA00164F-(cit141)/*[position()=1]
  publication-title: Biomed. Opt. Express
  doi: 10.1364/BOE.6.000559
– volume: 56
  start-page: 578
  year: 1984
  ident: C9JA00164F-(cit105)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac00267a062
– volume: 25
  start-page: 1897
  year: 2014
  ident: C9JA00164F-(cit15)/*[position()=1]
  publication-title: J. Am. Soc. Mass Spectrom.
  doi: 10.1007/s13361-014-0978-9
– volume: 231–232
  start-page: 146
  year: 2004
  ident: C9JA00164F-(cit17)/*[position()=1]
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/j.apsusc.2004.03.098
– volume: 252
  start-page: 7014
  year: 2006
  ident: C9JA00164F-(cit41)/*[position()=1]
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/j.apsusc.2006.02.169
– volume: 34
  start-page: 35
  year: 2002
  ident: C9JA00164F-(cit77)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/sia.1247
– volume: 75
  start-page: 6875
  year: 2003
  ident: C9JA00164F-(cit47)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac0302105
– volume: 17
  start-page: 4649
  year: 2001
  ident: C9JA00164F-(cit69)/*[position()=1]
  publication-title: Langmuir
  doi: 10.1021/la001209t
– volume: 67
  start-page: 1307
  year: 1995
  ident: C9JA00164F-(cit81)/*[position()=1]
  publication-title: Pure Appl. Chem.
  doi: 10.1351/pac199567081307
– volume: 141
  start-page: 90
  year: 2016
  ident: C9JA00164F-(cit120)/*[position()=1]
  publication-title: Analyst
  doi: 10.1039/C5AN01743B
– volume: 260
  start-page: 137
  year: 2007
  ident: C9JA00164F-(cit138)/*[position()=1]
  publication-title: Int. J. Mass Spectrom.
  doi: 10.1016/j.ijms.2006.09.029
– volume: 396
  start-page: 151
  year: 2010
  ident: C9JA00164F-(cit89)/*[position()=1]
  publication-title: Anal. Bioanal. Chem.
  doi: 10.1007/s00216-009-3031-2
– volume: 80
  start-page: 1942
  year: 2008
  ident: C9JA00164F-(cit129)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac701921e
– volume: 125
  start-page: 133
  year: 2013
  ident: C9JA00164F-(cit95)/*[position()=1]
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-012-1041-1
– volume: 88
  start-page: 3592
  year: 2016
  ident: C9JA00164F-(cit112)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.5b04133
– volume: 299–300
  start-page: 246
  year: 1994
  ident: C9JA00164F-(cit10)/*[position()=1]
  publication-title: Surf. Sci.
  doi: 10.1016/0039-6028(94)90658-0
– volume: 26
  start-page: 948
  year: 2015
  ident: C9JA00164F-(cit88)/*[position()=1]
  publication-title: J. Am. Soc. Mass Spectrom.
  doi: 10.1007/s13361-015-1146-6
– start-page: 1
  year: 2001
  ident: C9JA00164F-(cit8)/*[position()=1]
  publication-title: ToF-SIMS
– volume: 49
  start-page: 438
  year: 2008
  ident: C9JA00164F-(cit85)/*[position()=1]
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M700421-JLR200
– volume: 231–232
  start-page: 366
  year: 2004
  ident: C9JA00164F-(cit66)/*[position()=1]
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/j.apsusc.2004.03.100
– volume: 77
  start-page: 3452
  year: 2005
  ident: C9JA00164F-(cit104)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac0481349
– volume: 40
  start-page: 6217
  year: 1999
  ident: C9JA00164F-(cit75)/*[position()=1]
  publication-title: Tetrahedron Lett.
  doi: 10.1016/S0040-4039(99)01158-2
– volume: 255
  start-page: 1298
  year: 2008
  ident: C9JA00164F-(cit39)/*[position()=1]
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/j.apsusc.2008.05.139
– volume: 75
  start-page: 1754
  year: 2003
  ident: C9JA00164F-(cit16)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac026338o
– volume: 127
  start-page: 12152
  year: 2005
  ident: C9JA00164F-(cit100)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja051223y
– volume: 89
  start-page: 8223
  year: 2017
  ident: C9JA00164F-(cit74)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.7b02573
– volume: 70
  start-page: 9012
  year: 2010
  ident: C9JA00164F-(cit142)/*[position()=1]
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-10-0360
– volume: 179
  start-page: 161
  year: 2001
  ident: C9JA00164F-(cit119)/*[position()=1]
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/S0169-4332(01)00276-8
– volume: 1841
  start-page: 1108
  year: 2014
  ident: C9JA00164F-(cit84)/*[position()=1]
  publication-title: Biochim. Biophys. Acta, Mol. Cell Biol. Lipids
  doi: 10.1016/j.bbalip.2014.03.003
– volume: 38
  start-page: 1401
  year: 2006
  ident: C9JA00164F-(cit91)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/sia.2361
– volume: 231–232
  start-page: 250
  year: 2004
  ident: C9JA00164F-(cit44)/*[position()=1]
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/j.apsusc.2004.03.029
– volume: 47
  start-page: 301
  year: 1975
  ident: C9JA00164F-(cit12)/*[position()=1]
  publication-title: Surf. Sci.
  doi: 10.1016/0039-6028(75)90297-6
– volume: 79
  start-page: 3673
  year: 2007
  ident: C9JA00164F-(cit51)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac062406l
– volume: 29
  start-page: 1187
  year: 2015
  ident: C9JA00164F-(cit90)/*[position()=1]
  publication-title: Rapid Commun. Mass Spectrom.
  doi: 10.1002/rcm.7210
– volume: 9
  start-page: e99319
  year: 2014
  ident: C9JA00164F-(cit107)/*[position()=1]
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0099319
– volume: 85
  start-page: 10869
  year: 2013
  ident: C9JA00164F-(cit122)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac402288d
– volume: 10
  start-page: 1694
  year: 2010
  ident: C9JA00164F-(cit76)/*[position()=1]
  publication-title: Proteomics
  doi: 10.1002/pmic.200900782
– volume: 69
  start-page: 2225
  year: 1997
  ident: C9JA00164F-(cit135)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac9701748
– volume: 1811
  start-page: 976
  year: 2011
  ident: C9JA00164F-(cit83)/*[position()=1]
  publication-title: Biochim. Biophys. Acta, Mol. Cell Biol. Lipids
  doi: 10.1016/j.bbalip.2011.05.007
– volume: 76
  start-page: 6777
  year: 2004
  ident: C9JA00164F-(cit52)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac049108d
– volume: 19
  start-page: 1851
  year: 2005
  ident: C9JA00164F-(cit35)/*[position()=1]
  publication-title: Rapid Commun. Mass Spectrom.
  doi: 10.1002/rcm.1995
– volume: 28
  start-page: 202
  year: 2008
  ident: C9JA00164F-(cit94)/*[position()=1]
  publication-title: Clin. Physiol. Funct. Imaging
  doi: 10.1111/j.1475-097X.2008.00796.x
– volume: 70
  start-page: 828
  year: 2007
  ident: C9JA00164F-(cit97)/*[position()=1]
  publication-title: Microsc. Res. Tech.
  doi: 10.1002/jemt.20481
– volume: 78
  start-page: 734
  year: 2005
  ident: C9JA00164F-(cit43)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac0513111
– volume: 231–232
  start-page: 159
  year: 2004
  ident: C9JA00164F-(cit32)/*[position()=1]
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/j.apsusc.2004.03.104
– volume: 11
  start-page: 02A325
  year: 2016
  ident: C9JA00164F-(cit49)/*[position()=1]
  publication-title: Biointerphases
  doi: 10.1116/1.4942884
– volume: 3
  start-page: 451
  year: 1985
  ident: C9JA00164F-(cit78)/*[position()=1]
  publication-title: J. Vac. Sci. Technol., A
  doi: 10.1116/1.573015
– volume: 43
  start-page: 354
  year: 2011
  ident: C9JA00164F-(cit123)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/sia.3415
– volume: 11
  start-page: 02A317
  year: 2016
  ident: C9JA00164F-(cit33)/*[position()=1]
  publication-title: Biointerphases
  doi: 10.1116/1.4941009
– volume: 34
  start-page: 874
  year: 2019
  ident: C9JA00164F-(cit125)/*[position()=1]
  publication-title: J. Anal. At. Spectrom.
  doi: 10.1039/C8JA00425K
– volume: 33
  start-page: 715
  year: 2002
  ident: C9JA00164F-(cit65)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/sia.1438
– volume: 40
  start-page: 160
  year: 2005
  ident: C9JA00164F-(cit60)/*[position()=1]
  publication-title: J. Mass Spectrom.
  doi: 10.1002/jms.735
– volume: 84
  start-page: 4880
  year: 2012
  ident: C9JA00164F-(cit130)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac300480g
– volume: 57
  start-page: 23
  year: 2013
  ident: C9JA00164F-(cit134)/*[position()=1]
  publication-title: Org. Geochem.
  doi: 10.1016/j.orggeochem.2013.01.005
– volume: 203–204
  start-page: 223
  year: 2003
  ident: C9JA00164F-(cit18)/*[position()=1]
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/S0169-4332(02)00631-1
– volume: 25
  start-page: 1819
  year: 2014
  ident: C9JA00164F-(cit82)/*[position()=1]
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e13-09-0516
– volume: 12
  start-page: 366
  year: 2015
  ident: C9JA00164F-(cit144)/*[position()=1]
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3296
– volume: 67
  start-page: 179
  year: 2003
  ident: C9JA00164F-(cit72)/*[position()=1]
  publication-title: J. Biomed. Mater. Res., Part A
  doi: 10.1002/jbm.a.10063
– volume: 115
  start-page: 24247
  year: 2011
  ident: C9JA00164F-(cit67)/*[position()=1]
  publication-title: J. Phys. Chem. C
  doi: 10.1021/jp208035x
– volume: 18
  start-page: 406
  year: 2007
  ident: C9JA00164F-(cit19)/*[position()=1]
  publication-title: J. Am. Soc. Mass Spectrom.
  doi: 10.1016/j.jasms.2006.10.017
– volume: 63
  start-page: 1625
  year: 1989
  ident: C9JA00164F-(cit29)/*[position()=1]
  publication-title: Phys. Rev. Lett.
  doi: 10.1103/PhysRevLett.63.1625
– volume: 87
  start-page: 4055
  year: 2015
  ident: C9JA00164F-(cit113)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac504604g
– volume: 7
  start-page: 293
  year: 1996
  ident: C9JA00164F-(cit37)/*[position()=1]
  publication-title: J. Am. Soc. Mass Spectrom.
  doi: 10.1016/1044-0305(95)00703-2
– volume: 85
  start-page: 522
  year: 2013
  ident: C9JA00164F-(cit1)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac303290s
– volume: 76
  start-page: 4271
  year: 2004
  ident: C9JA00164F-(cit86)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac049389p
– volume: 9
  start-page: 2622
  year: 2009
  ident: C9JA00164F-(cit137)/*[position()=1]
  publication-title: Proteomics
  doi: 10.1002/pmic.200800364
– volume: 1
  start-page: I960
  year: 1962
  ident: C9JA00164F-(cit4)/*[position()=1]
  publication-title: J. Microsc.
– volume: 46
  start-page: 51
  year: 2014
  ident: C9JA00164F-(cit24)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/sia.5606
– volume: 9
  start-page: 2915
  year: 2019
  ident: C9JA00164F-(cit146)/*[position()=1]
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-38914-y
– volume: 75
  start-page: 5036
  year: 2012
  ident: C9JA00164F-(cit6)/*[position()=1]
  publication-title: J. Proteomics
  doi: 10.1016/j.jprot.2012.03.017
– volume: 30
  start-page: 142
  year: 2011
  ident: C9JA00164F-(cit128)/*[position()=1]
  publication-title: Mass Spectrom. Rev.
  doi: 10.1002/mas.20275
– volume: 120
  start-page: 26328
  year: 2016
  ident: C9JA00164F-(cit132)/*[position()=1]
  publication-title: J. Phys. Chem. C
  doi: 10.1021/acs.jpcc.6b08646
– volume: 252
  start-page: 6624
  year: 2006
  ident: C9JA00164F-(cit57)/*[position()=1]
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/j.apsusc.2006.02.206
– volume: 45
  start-page: 312
  year: 2013
  ident: C9JA00164F-(cit22)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/sia.5093
– volume: 5
  start-page: 413
  year: 2007
  ident: C9JA00164F-(cit92)/*[position()=1]
  publication-title: Geobiology
  doi: 10.1111/j.1472-4669.2007.00119.x
– volume: 83
  start-page: 3793
  year: 2011
  ident: C9JA00164F-(cit25)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac200288v
– volume: 129
  start-page: 9429
  year: 2007
  ident: C9JA00164F-(cit79)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja071879m
– volume: 84
  start-page: 10628
  year: 2012
  ident: C9JA00164F-(cit80)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac3019334
– volume: 3
  start-page: 311
  year: 1992
  ident: C9JA00164F-(cit36)/*[position()=1]
  publication-title: J. Am. Soc. Mass Spectrom.
  doi: 10.1016/1044-0305(92)87058-7
– volume: 68
  start-page: 873
  year: 1996
  ident: C9JA00164F-(cit42)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac950717i
– volume: 75
  start-page: 2333
  year: 2003
  ident: C9JA00164F-(cit59)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac026434p
– volume: 255
  start-page: 941
  year: 2008
  ident: C9JA00164F-(cit38)/*[position()=1]
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/j.apsusc.2008.05.007
– volume: 26
  start-page: 606
  year: 2007
  ident: C9JA00164F-(cit9)/*[position()=1]
  publication-title: Mass Spectrom. Rev.
  doi: 10.1002/mas.20124
– volume: 252
  start-page: 6836
  year: 2006
  ident: C9JA00164F-(cit30)/*[position()=1]
  publication-title: Appl. Surf. Sci.
  doi: 10.1016/j.apsusc.2006.02.142
– volume: 83
  start-page: 8308
  year: 2011
  ident: C9JA00164F-(cit56)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac202222h
– volume: 27
  start-page: 2033
  year: 2016
  ident: C9JA00164F-(cit127)/*[position()=1]
  publication-title: J. Am. Soc. Mass Spectrom.
  doi: 10.1007/s13361-016-1485-y
– volume: 18
  start-page: 371
  year: 2004
  ident: C9JA00164F-(cit34)/*[position()=1]
  publication-title: Rapid Commun. Mass Spectrom.
  doi: 10.1002/rcm.1342
– volume: 200
  start-page: 83
  year: 2000
  ident: C9JA00164F-(cit140)/*[position()=1]
  publication-title: J. Microsc.
  doi: 10.1046/j.1365-2818.2000.00738.x
– volume: 77
  start-page: 143
  year: 2005
  ident: C9JA00164F-(cit26)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac053355f
– volume: 57
  start-page: 2290
  year: 1985
  ident: C9JA00164F-(cit106)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac00289a027
– volume: 90
  start-page: 240
  year: 2018
  ident: C9JA00164F-(cit139)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.7b04733
– volume: 38
  start-page: 191
  year: 2006
  ident: C9JA00164F-(cit71)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/sia.2233
– volume: 86
  start-page: 9139
  year: 2014
  ident: C9JA00164F-(cit143)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac5020222
– volume: 1217
  start-page: 3946
  year: 2010
  ident: C9JA00164F-(cit7)/*[position()=1]
  publication-title: J. Chromatogr. A
  doi: 10.1016/j.chroma.2010.01.033
– volume: 74
  start-page: 43
  year: 1992
  ident: C9JA00164F-(cit11)/*[position()=1]
  publication-title: Biol. Cell.
  doi: 10.1016/0248-4900(92)90007-N
– volume: 20
  start-page: 3704
  year: 2004
  ident: C9JA00164F-(cit58)/*[position()=1]
  publication-title: Langmuir
  doi: 10.1021/la0358419
– volume: 19
  start-page: 6271
  year: 2003
  ident: C9JA00164F-(cit70)/*[position()=1]
  publication-title: Langmuir
  doi: 10.1021/la034081z
– volume: 34
  start-page: 03H126
  year: 2016
  ident: C9JA00164F-(cit110)/*[position()=1]
  publication-title: J. Vac. Sci. Technol., B: Nanotechnol. Microelectron.: Mater., Process., Meas., Phenom.
– volume: 45
  start-page: 277
  year: 2013
  ident: C9JA00164F-(cit101)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/sia.5055
– volume: 87
  start-page: 2367
  year: 2015
  ident: C9JA00164F-(cit23)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac504191m
– volume: 88
  start-page: 3091
  year: 2016
  ident: C9JA00164F-(cit55)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.5b03979
– volume: 75
  start-page: 3429
  year: 2003
  ident: C9JA00164F-(cit96)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac0207675
– volume: 74
  start-page: 4955
  year: 2002
  ident: C9JA00164F-(cit46)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac020125h
– volume: 12
  start-page: 2425
  year: 1994
  ident: C9JA00164F-(cit27)/*[position()=1]
  publication-title: J. Vac. Sci. Technol., A
  doi: 10.1116/1.579185
– volume: 566
  start-page: 291
  year: 2004
  ident: C9JA00164F-(cit45)/*[position()=1]
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2004.04.052
– volume: 37
  start-page: 1111
  year: 2005
  ident: C9JA00164F-(cit48)/*[position()=1]
  publication-title: Surf. Interface Anal.
  doi: 10.1002/sia.2121
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Snippet This concise tutorial review provides a description of the current state of the art in the application of time-of flight based secondary ion mass spectrometry...
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SubjectTerms Identification methods
Imaging
Ions
Secondary ion mass spectrometry
Title A concise tutorial review of TOF-SIMS based molecular and cellular imaging
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