Methylated ctDNA Quantification: Noninvasive Approach to Monitoring Hepatocellular Carcinoma Burden

• Published in: Journal of the American College of Surgeons Vol. 238; no. 4; pp. 770 - 778
• Main Authors: Angeli-Pahim, Isabella, Chambers, Anastasia, Duarte, Sergio, Soma, Daiki, Beduschi, Thiago, Sahin, Ilyas, Hughes, Steven, Zarrinpar, Ali
• Format: Journal Article
• Language: English
• Published: United States 01.04.2024
• Subjects: Biomarkers, Tumor - genetics; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - surgery; Circulating Tumor DNA - genetics; Fetal Proteins; Humans; Liver Neoplasms - diagnosis; Liver Neoplasms - genetics; Liver Neoplasms - therapy

Noninvasive, precision monitoring of hepatocellular carcinoma (HCC) treatment efficacy would greatly facilitate personalized therapy and improve patient outcomes. We hypothesize that quantifying methylated circulating tumor DNA (ctDNA) can be used to effectively monitor HCC burden without the need f...