An enhancer RNA recruits KMT2A to regulate transcription of Myb

• Published in: Cell reports (Cambridge) Vol. 43; no. 7; p. 114378
• Main Authors: Kim, Juhyun, Diaz, Luis F., Miller, Matthew J., Leadem, Benjamin, Krivega, Ivan, Dean, Ann
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.07.2024; Elsevier
• Subjects: CP: Molecular biology; enhancer hub; enhancer RNA; erythroid differentiation; gene expression; H3K4me3; KMT2A; lncRNA; MLL1; Myb; Pol II pause release; MLL1; enhancer hub; enhancer RNA; lncRNA; KMT2A; H3K4me3; Myb; CP: Molecular biology; Pol II pause release; gene expression; erythroid differentiation

The Myb proto-oncogene encodes the transcription factor c-MYB, which is critical for hematopoiesis. Distant enhancers of Myb form a hub of interactions with the Myb promoter. We identified a long non-coding RNA (Myrlin) originating from the −81-kb murine Myb enhancer. Myrlin and Myb are coordinately...