Evaluating the transcriptional regulators of arterial gene expression via a catalogue of characterized arterial enhancers

• Published in: eLife Vol. 14
• Main Authors: Nornes, Svanhild, Bruche, Susann, Adak, Niharika, McCracken, Ian R, De Val, Sarah
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 17.01.2025; eLife Sciences Publications, Ltd
• Subjects: Angiogenesis; Animal models; Animals; arterial enhancer; arterial gene transcription; Arteries; Arteries - metabolism; arteriovenous differentiation; Blood vessels; CXCL12 protein; CXCR4 protein; Danio rerio; Developmental Biology; Endothelial cells; Endothelium; Enhancer Elements, Genetic; Enhancers; ETS protein; Gene expression; Gene Expression Regulation; Gene Expression Regulation, Developmental; Gene regulation; Genetic control; Genetics and Genomics; Genomes; KLF4 protein; Kruppel-Like Factor 4; LEF/TCF protein; Metabolism; Mice; Mice, Transgenic; Myocyte enhancer factor 2; Nucleotide sequence; Smad2 protein; SOXF transcription factors; Transcription factors; Transcription Factors - metabolism; Transcription, Genetic; transcriptional regulation; Transgenic mice; vascular development; Veins & arteries; Wnt protein; Zebrafish - genetics; SOXF transcription factors; mouse; genetics; vascular development; developmental biology; transcriptional regulation; arterial gene transcription; arteriovenous differentiation; genomics; zebrafish; arterial enhancer

The establishment and growth of the arterial endothelium require the coordinated expression of numerous genes. However, regulation of this process is not yet fully understood. Here, we combined in silico analysis with transgenic mice and zebrafish models to characterize arterial-specific enhancers a...