Plasma 1-palmitoyl-2-linoleoyl phosphatidylcholine. Evidence for extensive phospholipase A1 hydrolysis and hepatic metabolism of the products

• Published in: The Journal of biological chemistry Vol. 266; no. 27; pp. 18002 - 18011
• Main Authors: Scagnelli, G.P., Cooper, P.S., VandenBroek, J.M., Berman, W.F., Schwartz, C.C.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Biochemistry and Molecular Biology 25.09.1991
• Subjects: Analytical, structural and metabolic biochemistry; Animals; Biological and medical sciences; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Enzymes and enzyme inhibitors; Fundamental and applied biological sciences. Psychology; Hydrolases; Hydrolysis; Liver - metabolism; Male; Phosphatidylcholines - blood; Phospholipases A - metabolism; Phospholipases A1; Rats; Rats, Inbred Strains; Vertebrata; Mammalia; Rat; Enzyme; Liver; Rodentia; Phosphatidylcholine; Phospholipase A; Quantitative analysis

1-Palmitoyl-2-linoleoyl phosphatidylcholine (PLPC) labeled in either the choline, glycerol, palmitate, or linoleate component in reconstituted rat high density lipoprotein (rHDL), was administered by vein to rats with bile fistula and taurocholate infusion. PLPC disappeared from plasma in a monoexpo...