Diagnosis of Prosthetic Joint Infection by Use of PCR-Electrospray Ionization Mass Spectrometry

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Published inJournal of Clinical Microbiology Vol. 52; no. 2; pp. 642 - 649
Main Authors Greenwood-Quaintance, Kerryl E., Uhl, James R., Hanssen, Arlen D., Sampath, Rangarajan, Mandrekar, Jayawant N., Patel, Robin
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.02.2014
Subjects
Adult
Aged
Aged, 80 and over
Arthritis - diagnosis
Arthroplasty, Replacement, Hip - adverse effects
Arthroplasty, Replacement, Knee - adverse effects
Bacteriology
Female
Humans
Male
Microbiological Techniques - methods
Middle Aged
Polymerase Chain Reaction - methods
Prostheses and Implants - microbiology
Prosthesis-Related Infections - diagnosis
Sensitivity and Specificity
Spectrometry, Mass, Electrospray Ionization - methods
Young Adult
Online AccessGet full text
ISSN0095-1137
1098-660X
1098-660X
DOI10.1128/JCM.03217-13

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Abstract Classifications Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JCM About JCM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JCM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0095-1137 Online ISSN: 1098-660X Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JCM .asm.org, visit: JCM       
AbstractList We compared PCR-electrospray ionization mass spectrometry (PCR-ESI/MS) to culture using sonicate fluid from 431 subjects with explanted knee ( n = 270) or hip ( n = 161) prostheses. Of these, 152 and 279 subjects had prosthetic joint infection (PJI) and aseptic failure, respectively. The sensitivities for detecting PJI were 77.6% for PCR-ESI/MS and 69.7% for culture ( P = 0.0105). The specificities were 93.5 and 99.3%, respectively ( P = 0.0002).
We compared PCR-electrospray ionization mass spectrometry (PCR-ESI/MS) to culture using sonicate fluid from 431 subjects with explanted knee (n = 270) or hip (n = 161) prostheses. Of these, 152 and 279 subjects had prosthetic joint infection (PJI) and aseptic failure, respectively. The sensitivities for detecting PJI were 77.6% for PCR-ESI/MS and 69.7% for culture (P = 0.0105). The specificities were 93.5 and 99.3%, respectively (P = 0.0002).We compared PCR-electrospray ionization mass spectrometry (PCR-ESI/MS) to culture using sonicate fluid from 431 subjects with explanted knee (n = 270) or hip (n = 161) prostheses. Of these, 152 and 279 subjects had prosthetic joint infection (PJI) and aseptic failure, respectively. The sensitivities for detecting PJI were 77.6% for PCR-ESI/MS and 69.7% for culture (P = 0.0105). The specificities were 93.5 and 99.3%, respectively (P = 0.0002).
We compared PCR-electrospray ionization mass spectrometry (PCR-ESI/MS) to culture using sonicate fluid from 431 subjects with explanted knee (n = 270) or hip (n = 161) prostheses. Of these, 152 and 279 subjects had prosthetic joint infection (PJI) and aseptic failure, respectively. The sensitivities for detecting PJI were 77.6% for PCR-ESI/MS and 69.7% for culture (P = 0.0105). The specificities were 93.5 and 99.3%, respectively (P = 0.0002).
Classifications Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue JCM About JCM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JCM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0095-1137 Online ISSN: 1098-660X Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JCM .asm.org, visit: JCM       
Author Robin Patel
Jayawant N. Mandrekar
Rangarajan Sampath
James R. Uhl
Arlen D. Hanssen
Kerryl E. Greenwood-Quaintance
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Snippet Classifications Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit...
We compared PCR-electrospray ionization mass spectrometry (PCR-ESI/MS) to culture using sonicate fluid from 431 subjects with explanted knee ( n = 270) or hip...
We compared PCR-electrospray ionization mass spectrometry (PCR-ESI/MS) to culture using sonicate fluid from 431 subjects with explanted knee (n = 270) or hip...
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SubjectTerms Adult
Aged
Aged, 80 and over
Arthritis - diagnosis
Arthroplasty, Replacement, Hip - adverse effects
Arthroplasty, Replacement, Knee - adverse effects
Bacteriology
Female
Humans
Male
Microbiological Techniques - methods
Middle Aged
Polymerase Chain Reaction - methods
Prostheses and Implants - microbiology
Prosthesis-Related Infections - diagnosis
Sensitivity and Specificity
Spectrometry, Mass, Electrospray Ionization - methods
Young Adult
Title Diagnosis of Prosthetic Joint Infection by Use of PCR-Electrospray Ionization Mass Spectrometry
URI http://jcm.asm.org/content/52/2/642.abstract
https://www.ncbi.nlm.nih.gov/pubmed/24478503
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