A general asymmetric copper-catalysed Sonogashira C(sp3)–C(sp) coupling

• Published in: Nature chemistry Vol. 11; no. 12; pp. 1158 - 1166
• Main Authors: Dong, Xiao-Yang, Zhang, Yu-Feng, Ma, Can-Liang, Gu, Qiang-Shuai, Wang, Fu-Li, Li, Zhong-Liang, Jiang, Sheng-Peng, Liu, Xin-Yuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2019; Springer Nature; Nature Publishing Group
• Subjects: 639/638/403/935; 639/638/549/933; 639/638/549/972; 639/638/77/883; 639/638/77/888; Acetylene; Alkynes; Analytical Chemistry; Asymmetry; Biochemistry; Chemical synthesis; Chemistry; Chemistry and Materials Science; Chemistry, Multidisciplinary; Chemistry/Food Science; Copper; Coupling (molecular); Covalent bonds; Cross coupling; Forging; Halides; Inorganic Chemistry; Natural products; Organic Chemistry; Physical Chemistry; Physical Sciences; Science & Technology; HYDROGEN; IODIDES; METHODOLOGY; CROSS-COUPLINGS; NICKEL; ACETYLENE; ARYL; ALDEHYDES; ALKYL BROMIDES; DERIVATIVES

Continued development of the Sonogashira coupling has made it a well established and versatile reaction for the straightforward formation of C–C bonds, forging the carbon skeletons of broadly useful functionalized molecules. However, asymmetric Sonogashira coupling, particularly for C( sp 3 )–C( sp...