Over-Expression of Bcl-2 Provides Protection in Septic Mice by a trans Effect

• Published in: The Journal of immunology (1950) Vol. 171; no. 6; pp. 3136 - 3141
• Main Authors: Iwata, Akiko, Stevenson, Vicki Morgan, Minard, Annie, Tasch, Michael, Tupper, Joan, Lagasse, Eric, Weissman, Irving, Harlan, John M, Winn, Robert K
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.09.2003
• Subjects: Adoptive Transfer; Animals; Apoptosis - genetics; Ascitic Fluid - genetics; Ascitic Fluid - microbiology; Ascitic Fluid - pathology; Ascitic Fluid - prevention & control; Bone Marrow Transplantation - immunology; CD11b Antigen - biosynthesis; Cecum; Colony Count, Microbial; Cytokines - analysis; Homeodomain Proteins - genetics; Humans; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Intestinal Mucosa - pathology; Leukocyte Count; Ligation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Myeloid Cells - metabolism; Peritoneal Lavage; Proto-Oncogene Proteins c-bcl-2 - biosynthesis; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - physiology; Punctures; Sepsis - genetics; Sepsis - microbiology; Sepsis - pathology; Sepsis - prevention & control; Survival Analysis; T-Lymphocytes - metabolism

Transgenic mice that over-express B cell leukemia/lymphomas (Bcl)-2 in myeloid cells under control of the human MRP8 promoter (hMRP8-Bcl-2) or in T lymphocytes under the E micro promoter (E micro -Bcl-2) were compared with C57BL/6 control mice following cecal ligation and puncture (CLP). There was a...