Glutamatergic synapse in autism: a complex story for a complex disorder

• Published in: Molecular psychiatry Vol. 28; no. 2; pp. 801 - 809
• Main Authors: Galineau, Laurent, Arlicot, Nicolas, Dupont, Anne-Claire, Briend, Frederic, Houy-Durand, Emmanuelle, Tauber, Clovis, Gomot, Marie, Gissot, Valérie, Barantin, Laurent, Lefevre, Antoine, Vercouillie, Johnny, Roussel, Catherine, Roux, Sylvie, Nadal, Lydie, Mavel, Sylvie, Laumonnier, Frédéric, Belzung, Catherine, Chalon, Sylvie, Emond, Patrick, Santiago-Ribeiro, Maria-Joao, Bonnet-Brilhault, Frédérique
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2023; Nature Publishing Group
• Subjects: 101/58; 59/36; 59/78; 631/378; 692/699/476/1373; Adolescent; Adult; Animal models; Animals; Autism; Autism Spectrum Disorder; Autistic Disorder; Behavioral Sciences; Biological Psychology; Brain; Child; Children; Cognitive science; Cortex (cingulate); Developmental stages; Female; Glutamatergic transmission; Glutamic Acid; Glutamic acid receptors (metabotropic); Human health and pathology; Humans; Hypotheses; Life Sciences; Magnetic resonance spectroscopy; Male; Medicine; Medicine & Public Health; Metabolomics; Neurodevelopmental disorders; Neuroimaging; Neuroscience; Neurosciences; Pathophysiology; Pharmacotherapy; Population density; Positron emission tomography; Pregnancy; Prenatal experience; Prenatal exposure; Psychiatrics and mental health; Psychiatry; Rats; Spectrum analysis; Synapses; Valproic Acid

Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathophysiological mechanisms are still unclear. Hypotheses suggest a role for glutamate dysfunctions in ASD development, but clinical studies investigating brain and peripheral glutamate levels showed heterogenous results leading...