The miRNA let-7a1 inhibits the expression of insulin-like growth factor 1 receptor (IGF1R) in prostate cancer PC-3 cells

• Published in: Asian journal of andrology Vol. 15; no. 6; pp. 753 - 758
• Main Authors: Wang, Li-Na, Chen, Wei-Wen, Zhang, Ju, Li, Chao-Yang, Liu, Chun-Yan, Xue, Jing, Zhang, Peng-Ju, Jiang, An-Li
• Format: Journal Article
• Language: English
• Published: China Medknow Publications & Media Pvt. Ltd 01.11.2013; Nature Publishing Group
• Subjects: 3' Untranslated Regions; Base Sequence; Cell Line, Tumor; DNA Primers; Humans; Male; MicroRNAs - genetics; Original; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Real-Time Polymerase Chain Reaction; Receptor, IGF Type 1 - genetics; RNA, Messenger - genetics

Reduced microRNA (miRNA) let-7a expression and the activation of insulin-like growth factor-1 receptor (IGF1R) signalling are both involved in prostate cancer and progression. In the present study, we demonstrated that the growth inhibitory effect of let-7a1 is directly related to targeting IGF1R ge...