Plasmacytoid Dendritic Cells Are Not Major Producers of Type 1 IFN in Cutaneous Lupus: An In-Depth Immunoprofile of Subacute and Discoid Lupus

• Published in: Journal of investigative dermatology Vol. 144; no. 6; pp. 1262 - 1272.e7
• Main Authors: Vazquez, Thomas, Patel, Jay, Kodali, Nilesh, Diaz, DeAnna, Bashir, Muhammad M., Chin, Felix, Keyes, Emily, Sharma, Meena, Sprow, Grant, Grinnell, Madison, Dan, Joshua, Werth, Victoria P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2024
• Subjects: Adult; Dendritic Cells - immunology; Dendritic Cells - metabolism; Dermatology; Female; Humans; IFN-α; Imaging mass cytometry; Immunology; Immunophenotyping; Interferon Type I - immunology; Interferon Type I - metabolism; Lupus Erythematosus, Cutaneous - immunology; Lupus Erythematosus, Cutaneous - pathology; Lupus Erythematosus, Discoid - immunology; Lupus Erythematosus, Discoid - pathology; Male; Middle Aged; Rheumatology; Skin - immunology; Skin - pathology; RT; cDC; Dermatology; Rheumatology; GZMB; IQR; SLE; pDC; SCLE; IFN-α; Immunology; CSB; Th; HC; DLE; CLASI; CLE; CyTOF; Imaging mass cytometry; IMC

The immunologic drivers of cutaneous lupus erythematosus (CLE) and its clinical subtypes remain poorly understood. We sought to characterize the immune landscape of discoid lupus erythematosus and subacute CLE using multiplexed immunophenotyping. We found no significant differences in immune cell pe...