Selective Degradation of MLK3 by a Novel CEP1347-VHL-02 PROTAC Compound Limits the Oncogenic Potential of TNBC - Karpińska, Kamila; Mehlich, Dawid; Sabbasani, Venkata R.; Łomiak, Michał; Torres-Ayuso, Pedro; Wróbel, Katarzyna; Truong, Vi Nguyen-Phuong; Serwa, Remigiusz; Swenson, Rolf E.; Brognard, John; Marusiak, Anna A. (Journal of medicinal chemistry, 2024)
Keywords: Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Cell Line, Tumor; Cell Proliferation - drug effects; Chemistry, Medicinal; Female; Humans; Life Sciences & Biomedicine; Mitogen-Activated Protein Kinase Kinase Kinase 11; Pharmacology & Pharmacy; Protein Kinase Inhibitors - chemical synthesis; Protein Kinase Inhibitors - chemistry; Protein Kinase Inhibitors - pharmacology; Proteolysis - drug effects; Science & Technology; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - metabolism; Triple Negative Breast Neoplasms - pathology; Von Hippel-Lindau Tumor Suppressor Protein - metabolism; ACTIVATION; INVASION; COMPUTATIONAL PLATFORM; PHOSPHORYLATION; MIXED-LINEAGE KINASE-3; B-RAF; INHIBITOR; CANCER CELL-MIGRATION