Peroxisome Proliferator–Activated Receptor-α Agonist Treatment in a Transgenic Model of Type 2 Diabetes Reverses the Lipotoxic State and Improves Glucose Homeostasis

• Published in: Diabetes (New York, N.Y.) Vol. 52; no. 7; pp. 1770 - 1778
• Main Authors: KIM, Hyunsook, HALUZIK, Martin, WHEELER, Michael B, LEROITH, Derek, ASGHAR, Zeenat, DAPHNE YAU, JOSEPH, Jamie W, FERNANDEZ, Ana M, REITMAN, Marc L, YAKAR, Shoshana, STANNARD, Bethel, HERON-MILHAVET, Lisa
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.07.2003
• Subjects: Animals; Biological and medical sciences; Diabetes Mellitus, Type 2 - blood; Fundamental and applied biological sciences. Psychology; Gluconeogenesis - drug effects; Glucose - metabolism; Glucose Clamp Technique; Homeostasis; Kinetics; Lipids - blood; Liver - drug effects; Liver - metabolism; Mice; Mice, Inbred Strains; Mice, Transgenic; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Pyrimidines - pharmacology; Receptor, IGF Type 1 - genetics; Receptor, IGF Type 1 - physiology; Receptors, Cytoplasmic and Nuclear - agonists; Receptors, Cytoplasmic and Nuclear - drug effects; Receptors, Cytoplasmic and Nuclear - genetics; RNA, Messenger - genetics; RNA, Ribosomal, 18S - drug effects; RNA, Ribosomal, 18S - genetics; Time Factors; Transcription Factors - agonists; Transcription Factors - drug effects; Transcription Factors - genetics; Triglycerides - metabolism

Peroxisome Proliferator–Activated Receptor-α Agonist Treatment in a Transgenic Model of Type 2 Diabetes Reverses the Lipotoxic State and Improves Glucose Homeostasis Hyunsook Kim 1 , Martin Haluzik 1 , Zeenat Asghar 2 , Daphne Yau 2 , Jamie W. Joseph 2 , Ana M. Fernandez 1 , Marc L. Reitman 1 , Shos...