Surfactant Provided Control of Crystallization Polymorphic Outcome and Stabilization of Metastable Polymorphs of 2,6-Dimethoxyphenylboronic Acid

• Published in: Crystals (Basel) Vol. 12; no. 12; p. 1738
• Main Authors: Semjonova, Aina, Bērziņš, Agris
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.12.2022
• Subjects: 2,6-Dimethoxyphenylboronic acid; Additives; Alcohols; Analysis; Cooling; crystal structure analysis; Crystallization; crystallization additives; Drug dosages; Evaporative cooling; Pharmaceutical industry; Phase transitions; Polymers; polymorphism; Solvents; Surface active agents; Surface analysis (chemical); Surfactants; Thermodynamics

2,6-Dimethoxyphenylboronic acid was used as a model substance to investigate the additive crystallization approach for polymorph control in phenylboronic acids. It was crystallized under different conditions by performing evaporation and cooling crystallization from different solvents. Most of the c...