Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment

• Published in: Science (American Association for the Advancement of Science) Vol. 378; no. 6617; p. eabq4835
• Main Authors: Cheng, Shiya, Altmeppen, Gerrit, So, Chun, Welp, Luisa M., Penir, Sarah, Ruhwedel, Torben, Menelaou, Katerina, Harasimov, Katarina, Stützer, Alexandra, Blayney, Martyn, Elder, Kay, Möbius, Wiebke, Urlaub, Henning, Schuh, Melina
• Format: Journal Article
• Language: English
• Published: Washington The American Association for the Advancement of Science 21.10.2022
• Subjects: Assembly; Chromosomes; Clustering; Coalescence; Compartments; Cytokinesis; Cytoplasm; Degradation; Developmental stages; Eggs; Embryogenesis; Embryonic growth stage; Embryos; Endoplasmic reticulum; Endosomes; Fertility; Fertilization; Fluorescence in situ hybridization; Gametocytes; Genomes; Golgi apparatus; Granular materials; Hydrogels; Localization; Lysosomes; Mammals; Maturation; Meiosis; Membrane potential; Membranes; Mitochondria; Nucleic acids; Oocytes; Phase separation; Protein turnover; Proteins; Ribonucleic acid; RNA; RNA-binding protein; Storage; Transcription

Full-grown oocytes are transcriptionally silent and must stably maintain the messenger RNAs (mRNAs) needed for oocyte meiotic maturation and early embryonic development. However, where and how mammalian oocytes store maternal mRNAs is unclear. Here, we report that mammalian oocytes accumulate mRNAs...