Exploration of the Associations of lncRNA Expression Patterns with Tumor Mutation Burden and Prognosis in Colon Cancer

• Published in: OncoTargets and therapy Vol. 14; pp. 2893 - 2909
• Main Authors: Ding, Chengsheng, Shan, Zezhi, Li, Mengcheng, Xia, Yang, Jin, Zhiming
• Format: Journal Article
• Language: English
• Published: New Zealand Taylor & Francis Ltd 01.01.2021; Dove
• Subjects: Biomarkers; Colon cancer; Colorectal cancer; CTLA-4 protein; Cytolytic activity; Gene expression; Genomes; Immune checkpoint; Immune response; Immune system; Immunotherapy; Major histocompatibility complex; Medical prognosis; Metastases; Mortality; Mutation; Nomograms; Non-coding RNA; Original Research; Patients; PD-1 protein; PD-L1 protein; Polymerase chain reaction; Software; γ-Interferon; long non-coding RNA; tumor mutation burden; prognosis; colon cancer; immunotherapy

Tumor mutation burden (TMB) is emerging as a new biomarker to monitor the response of cancer patients to immunotherapy. Long non-coding RNAs (lncRNAs) are critical in regulating gene expression and play a significant role in cancer-associated immune responses. However, the association between lncRNA...