c-Jun N-terminal Kinase Activation by Hydrogen Peroxide in Endothelial Cells Involves Src-dependent Epidermal Growth Factor Receptor Transactivation

• Published in: The Journal of biological chemistry Vol. 276; no. 19; pp. 16045 - 16050
• Main Authors: Chen, Kai, Vita, Joseph A., Berk, Bradford C., Keaney, John F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.05.2001; American Society for Biochemistry and Molecular Biology
• Subjects: Adaptor Proteins, Signal Transducing; Animals; Aorta; Benzoquinones; Cells, Cultured; Endothelium, Vascular - cytology; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Enzyme Activation; Enzyme Inhibitors - pharmacology; ErbB Receptors - drug effects; ErbB Receptors - genetics; ErbB Receptors - metabolism; Genistein - pharmacology; GRB2 Adaptor Protein; Hydrogen Peroxide - pharmacology; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases - metabolism; Phosphorylation; Phosphotyrosine - metabolism; Protein-Tyrosine Kinases - metabolism; Proteins - drug effects; Proteins - genetics; Proteins - metabolism; Pyrimidines - pharmacology; Quinazolines; Quinones - pharmacology; Rifabutin - analogs & derivatives; Swine; Transcriptional Activation - drug effects; Transcriptional Activation - physiology; Tyrphostins - pharmacology

The phenotypic properties of the endothelium are subject to modulation by oxidative stress, and the c-Jun N-terminal kinase (JNK) pathway is important in mediating cellular responses to stress, although activation of this pathway in endothelial cells has not been fully characterized. Therefore, we e...