Receptor tyrosine kinases CAD96CA and FGFR1 function as the cell membrane receptors of insect juvenile hormone

Juvenile hormone (JH) is important to maintain insect larval status; however, its cell membrane receptor has not been identified. Using the lepidopteran insect Helicoverpa armigera (cotton bollworm), a serious agricultural pest, as a model, we determined that receptor tyrosine kinases (RTKs) cadheri...

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Published ineLife Vol. 13
Main Authors Li, Yan-Xue, Kang, Xin-Le, Li, Yan-Li, Wang, Xiao-Pei, Yan, Qiao, Wang, Jin-Xing, Zhao, Xiao-Fan
Format Journal Article
LanguageEnglish
Published England eLife Science Publications, Ltd 14.03.2025
eLife Sciences Publications Ltd
Subjects
agricultural pest
Animals
Biological research
Biology, Experimental
Cadherins - genetics
Cadherins - metabolism
Calcium (intracellular)
Cell Membrane - metabolism
Cell membranes
Cell receptors
Cell surface receptors
Cotton
CRISPR
Efficiency
Fibroblast growth factor receptor 1
Gene expression
Genomes
Genotype & phenotype
Growth factors
HEK293 Cells
Humans
Insect cells
Insect Proteins - genetics
Insect Proteins - metabolism
Insects
Intracellular
Juvenile hormones
Juvenile Hormones - metabolism
Kinases
Larva - genetics
Larva - metabolism
Lepidoptera
metamorphosis
Moths - enzymology
Moths - genetics
Moths - metabolism
Phosphorylation
Phylogenetics
Protein tyrosine kinase
Proteins
Receptor mechanisms
Receptor Protein-Tyrosine Kinases - genetics
Receptor Protein-Tyrosine Kinases - metabolism
Receptor, Fibroblast Growth Factor, Type 1 - genetics
Receptor, Fibroblast Growth Factor, Type 1 - metabolism
Signal Transduction
Transcription factors
Tyrosine
China
agricultural pest
metamorphosis
developmental biology
Lepidoptera
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Abstract Juvenile hormone (JH) is important to maintain insect larval status; however, its cell membrane receptor has not been identified. Using the lepidopteran insect Helicoverpa armigera (cotton bollworm), a serious agricultural pest, as a model, we determined that receptor tyrosine kinases (RTKs) cadherin 96ca (CAD96CA) and fibroblast growth factor receptor homologue (FGFR1) function as JH cell membrane receptors by their roles in JH-regulated gene expression, larval status maintaining, rapid intracellular calcium increase, phosphorylation of JH intracellular receptor MET1 and cofactor Taiman, and high affinity to JH III. Gene knockout of Cad96ca and Fgfr1 by CRISPR/Cas9 in embryo and knockdown in various insect cells, and overexpression of CAD96CA and FGFR1 in mammalian HEK-293T cells all supported CAD96CA and FGFR1 transmitting JH signal as JH cell membrane receptors.
AbstractList Juvenile hormone (JH) is important to maintain insect larval status; however, its cell membrane receptor has not been identified. Using the lepidopteran insect Helicoverpa armigera (cotton bollworm), a serious agricultural pest, as a model, we determined that receptor tyrosine kinases (RTKs) cadherin 96ca (CAD96CA) and fibroblast growth factor receptor homologue (FGFR1) function as JH cell membrane receptors by their roles in JH-regulated gene expression, larval status maintaining, rapid intracellular calcium increase, phosphorylation of JH intracellular receptor MET1 and cofactor Taiman, and high affinity to JH III. Gene knockout of Cad96ca and Fgfr1 by CRISPR/Cas9 in embryo and knockdown in various insect cells, and overexpression of CAD96CA and FGFR1 in mammalian HEK-293T cells all supported CAD96CA and FGFR1 transmitting JH signal as JH cell membrane receptors.
Juvenile hormone (JH) is important to maintain insect larval status; however, its cell membrane receptor has not been identified. Using the lepidopteran insect (cotton bollworm), a serious agricultural pest, as a model, we determined that receptor tyrosine kinases (RTKs) cadherin 96ca (CAD96CA) and fibroblast growth factor receptor homologue (FGFR1) function as JH cell membrane receptors by their roles in JH-regulated gene expression, larval status maintaining, rapid intracellular calcium increase, phosphorylation of JH intracellular receptor MET1 and cofactor Taiman, and high affinity to JH III. Gene knockout of and by CRISPR/Cas9 in embryo and knockdown in various insect cells, and overexpression of CAD96CA and FGFR1 in mammalian HEK-293T cells all supported CAD96CA and FGFR1 transmitting JH signal as JH cell membrane receptors.
Juvenile hormone (JH) is important to maintain insect larval status; however, its cell membrane receptor has not been identified. Using the lepidopteran insect Helicoverpa armigera (cotton bollworm), a serious agricultural pest, as a model, we determined that receptor tyrosine kinases (RTKs) cadherin 96ca (CAD96CA) and fibroblast growth factor receptor homologue (FGFR1) function as JH cell membrane receptors by their roles in JH-regulated gene expression, larval status maintaining, rapid intracellular calcium increase, phosphorylation of JH intracellular receptor MET1 and cofactor Taiman, and high affinity to JH III. Gene knockout of Cad96ca and Fgfr1 by CRISPR/Cas9 in embryo and knockdown in various insect cells, and overexpression of CAD96CA and FGFR1 in mammalian HEK-293T cells all supported CAD96CA and FGFR1 transmitting JH signal as JH cell membrane receptors.Juvenile hormone (JH) is important to maintain insect larval status; however, its cell membrane receptor has not been identified. Using the lepidopteran insect Helicoverpa armigera (cotton bollworm), a serious agricultural pest, as a model, we determined that receptor tyrosine kinases (RTKs) cadherin 96ca (CAD96CA) and fibroblast growth factor receptor homologue (FGFR1) function as JH cell membrane receptors by their roles in JH-regulated gene expression, larval status maintaining, rapid intracellular calcium increase, phosphorylation of JH intracellular receptor MET1 and cofactor Taiman, and high affinity to JH III. Gene knockout of Cad96ca and Fgfr1 by CRISPR/Cas9 in embryo and knockdown in various insect cells, and overexpression of CAD96CA and FGFR1 in mammalian HEK-293T cells all supported CAD96CA and FGFR1 transmitting JH signal as JH cell membrane receptors.
Audience Academic
Author Li, Yan-Xue
Zhao, Xiao-Fan
Wang, Xiao-Pei
Kang, Xin-Le
Li, Yan-Li
Wang, Jin-Xing
Yan, Qiao
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Keywords agricultural pest
metamorphosis
developmental biology
Lepidoptera
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SSID ssj0000748819
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Snippet Juvenile hormone (JH) is important to maintain insect larval status; however, its cell membrane receptor has not been identified. Using the lepidopteran insect...
SourceID doaj
proquest
gale
pubmed
crossref
SourceType Open Website
Aggregation Database
Index Database
SubjectTerms agricultural pest
Animals
Biological research
Biology, Experimental
Cadherins - genetics
Cadherins - metabolism
Calcium (intracellular)
Cell Membrane - metabolism
Cell membranes
Cell receptors
Cell surface receptors
Cotton
CRISPR
Efficiency
Fibroblast growth factor receptor 1
Gene expression
Genomes
Genotype & phenotype
Growth factors
HEK293 Cells
Humans
Insect cells
Insect Proteins - genetics
Insect Proteins - metabolism
Insects
Intracellular
Juvenile hormones
Juvenile Hormones - metabolism
Kinases
Larva - genetics
Larva - metabolism
Lepidoptera
metamorphosis
Moths - enzymology
Moths - genetics
Moths - metabolism
Phosphorylation
Phylogenetics
Protein tyrosine kinase
Proteins
Receptor mechanisms
Receptor Protein-Tyrosine Kinases - genetics
Receptor Protein-Tyrosine Kinases - metabolism
Receptor, Fibroblast Growth Factor, Type 1 - genetics
Receptor, Fibroblast Growth Factor, Type 1 - metabolism
Signal Transduction
Transcription factors
Tyrosine
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Title Receptor tyrosine kinases CAD96CA and FGFR1 function as the cell membrane receptors of insect juvenile hormone
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Volume 13
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