Cytokine Dysregulation Induced by Apoptotic Cells Is a Shared Characteristic of Murine Lupus

• Published in: The Journal of immunology (1950) Vol. 165; no. 8; pp. 4190 - 4201
• Main Authors: Koh, Jason S, Wang, Zhiyong, Levine, Jerrold S
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.10.2000
• Subjects: Animals; Apoptosis - immunology; Cells, Cultured; Culture Media, Conditioned; Culture Media, Serum-Free; Cytokines - biosynthesis; Cytokines - deficiency; Cytokines - metabolism; Disease Models, Animal; Disease Susceptibility; Female; Fetal Blood - immunology; Interleukin-1 - biosynthesis; Interleukin-1 - deficiency; Interleukin-1 - metabolism; Lipids - immunology; lupus; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - metabolism; Lupus Erythematosus, Systemic - pathology; Macrophages, Peritoneal - immunology; Macrophages, Peritoneal - metabolism; Macrophages, Peritoneal - pathology; Male; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred MRL lpr; Mice, Inbred NZB; Signal Transduction - immunology; Species Specificity

Of the multiple murine models of autoimmunity, the three most closely resembling human systemic lupus erythematosus (SLE) are the MRL/lpr, New Zealand Black/White F(1), and male BXSB. Although these strains share many disease characteristics, no common cellular defect has previously been found in pr...