Effects of long-term vasodilator therapy in patients with carotid sinus hypersensitivity
Background In patients affected by carotid sinus hypersensitivity, long-term vasodilator therapy might increase the risk of syncopal episodes by reducing systolic blood pressure and venous return to the heart. Methods and Results Thirty-two patients (mean age 73 ± 9 years; 20 men) who met all the fo...
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Published in | The American heart journal Vol. 136; no. 2; pp. 264 - 268 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Mosby, Inc
01.08.1998
Elsevier |
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Abstract | Background In patients affected by carotid sinus hypersensitivity, long-term vasodilator therapy might increase the risk of syncopal episodes by reducing systolic blood pressure and venous return to the heart.
Methods and Results Thirty-two patients (mean age 73 ± 9 years; 20 men) who met all the following criteria were included: (1) one or more episodes of syncope occurring during long-term (>6 months) treatment with angiotensin-converting enzyme inhibitors, long-acting nitrates, calcium antagonists, or a combination of these; (2) a positive response to carotid sinus massage, defined as the reproduction of spontaneous syncope in the presence of ventricular asystole ≥3 seconds or a fall in systolic blood pressure ≥50 mm Hg; (3) negative workup for other causes of syncope. The patients were randomly assigned to continue or to discontinue use of vasodilators; carotid sinus massage was repeated 2 weeks after randomization. By the end of the study period, the baseline values of systolic blood pressure were significantly different between the 2 groups of patients both in supine (P =.01) and upright (P =.03) positions. Syncope had been induced by carotid sinus massage in 81% of patients in the “on-vasodilator” group and in 62% of patients in the “off-vasodilator” group (P =.21). The cardioinhibitory reflex was of similar magnitude in the 2 groups, being found in 50% of the patients in each group, with a maximum ventricular pause of 7.1 ± 2.7 and 6.7 ± 1.8 seconds, respectively. The percentage decrease of blood pressure did not differ between the 2 groups, even if, in absolute values, the baseline difference of blood pressure roughly persisted for the duration of the test. In consequence of that, the rise of blood pressure to similar values was delayed approximately 30 seconds in the “on-vasodilator” group and took more than 2 minutes to return to baseline values.
Conclusions In patients affected by carotid sinus hypersensitivity, chronic vasodilator therapy does not have a direct effect on carotid sinus reflexivity, although the delayed recovery of pretest blood pressure values could indirectly potentiate the severity of the clinical manifestations of the syndrome. The persistence of hypotension for a longer time after the end of the massage suggests that vasodilators cause an impairment of compensatory mechanisms. (Am Heart J 1998;136:264-8.) |
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AbstractList | Background In patients affected by carotid sinus hypersensitivity, long-term vasodilator therapy might increase the risk of syncopal episodes by reducing systolic blood pressure and venous return to the heart.
Methods and Results Thirty-two patients (mean age 73 ± 9 years; 20 men) who met all the following criteria were included: (1) one or more episodes of syncope occurring during long-term (>6 months) treatment with angiotensin-converting enzyme inhibitors, long-acting nitrates, calcium antagonists, or a combination of these; (2) a positive response to carotid sinus massage, defined as the reproduction of spontaneous syncope in the presence of ventricular asystole ≥3 seconds or a fall in systolic blood pressure ≥50 mm Hg; (3) negative workup for other causes of syncope. The patients were randomly assigned to continue or to discontinue use of vasodilators; carotid sinus massage was repeated 2 weeks after randomization. By the end of the study period, the baseline values of systolic blood pressure were significantly different between the 2 groups of patients both in supine (P =.01) and upright (P =.03) positions. Syncope had been induced by carotid sinus massage in 81% of patients in the “on-vasodilator” group and in 62% of patients in the “off-vasodilator” group (P =.21). The cardioinhibitory reflex was of similar magnitude in the 2 groups, being found in 50% of the patients in each group, with a maximum ventricular pause of 7.1 ± 2.7 and 6.7 ± 1.8 seconds, respectively. The percentage decrease of blood pressure did not differ between the 2 groups, even if, in absolute values, the baseline difference of blood pressure roughly persisted for the duration of the test. In consequence of that, the rise of blood pressure to similar values was delayed approximately 30 seconds in the “on-vasodilator” group and took more than 2 minutes to return to baseline values.
Conclusions In patients affected by carotid sinus hypersensitivity, chronic vasodilator therapy does not have a direct effect on carotid sinus reflexivity, although the delayed recovery of pretest blood pressure values could indirectly potentiate the severity of the clinical manifestations of the syndrome. The persistence of hypotension for a longer time after the end of the massage suggests that vasodilators cause an impairment of compensatory mechanisms. (Am Heart J 1998;136:264-8.) In patients affected by carotid sinus hypersensitivity, long-term vasodilator therapy might increase the risk of syncopal episodes by reducing systolic blood pressure and venous return to the heart. Thirty-two patients (mean age 73 +/- 9 years; 20 men) who met all the following criteria were included: (1) one or more episodes of syncope occurring during long-term (>6 months) treatment with angiotensin-converting enzyme inhibitors, long-acting nitrates, calcium antagonists, or a combination of these; (2) a positive response to carotid sinus massage, defined as the reproduction of spontaneous syncope in the presence of ventricular asystole > or =3 seconds or a fall in systolic blood pressure > or =50 mm Hg; (3) negative workup for other causes of syncope. The patients were randomly assigned to continue or to discontinue use of vasodilators; carotid sinus massage was repeated 2 weeks after randomization. By the end of the study period, the baseline values of systolic blood pressure were significantly different between the 2 groups of patients both in supine (P=.01) and upright (P=.03) positions. Syncope had been induced by carotid sinus massage in 81% of patients in the "on-vasodilator" group and in 62% of patients in the "off-vasodilator" group (P=.21). The cardioinhibitory reflex was of similar magnitude in the 2 groups, being found in 50% of the patients in each group, with a maximum ventricular pause of 7.1 +/- 2.7 and 6.7 +/- 1.8 seconds, respectively. The percentage decrease of blood pressure did not differ between the 2 groups, even if, in absolute values, the baseline difference of blood pressure roughly persisted for the duration of the test. In consequence of that, the rise of blood pressure to similar values was delayed approximately 30 seconds in the "on-vasodilator" group and took more than 2 minutes to return to baseline values. In patients affected by carotid sinus hypersensitivity, chronic vasodilator therapy does not have a direct effect on carotid sinus reflexivity, although the delayed recovery of pretest blood pressure values could indirectly potentiate the severity of the clinical manifestations of the syndrome. The persistence of hypotension for a longer time after the end of the massage suggests that vasodilators cause an impairment of compensatory mechanisms. |
Author | Fradella, Giuseppe Mureddu, Roberto Gaggioli, Germano Bottoni, Nicola Mascioli, Giosuè Menozzi, Carlo Musso, Giacomo Foglia-Manzillo, Giovanni Brignole, Michele |
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Cites_doi | 10.1016/0002-9343(93)90261-M 10.1002/clc.4960121006 10.1136/bmj.1.5852.507 10.1093/geronj/44.6.M179 10.1111/j.1532-5415.1994.tb07493.x 10.1016/S0002-9149(96)00207-X 10.1212/WNL.46.5.1470 10.1016/S0002-9149(99)80596-7 10.1111/j.1532-5415.1994.tb06582.x 10.1111/j.1540-8159.1991.tb05090.x 10.1016/0021-9681(86)90187-6 |
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Keywords | Human Nervous system diseases Vasodilator agent Pathophysiology Toxicity Consciousness impairment Calcium antagonist Exploration Slow release form Nitrates Long term Concomitant disease Syncope Arterial hypotension Diseases of the autonomic nervous system Blood pressure Massage Neurological disorder Carotid sinus ACE inhibitor Hypersensitive carotid sinus syndrome |
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method for the choice of the pacing mode in carotid sinus syndrome with or without sinus bradycardia publication-title: PACE doi: 10.1111/j.1540-8159.1991.tb05090.x contributor: fullname: Brignole – volume: 39 start-page: 619 year: 1986 ident: 10.1053/hj.1998.v136.89911_bib12 article-title: Syncope in institutionalized elderly: the impact of multiple pathological conditions and situational stress publication-title: J Chron Dis doi: 10.1016/0021-9681(86)90187-6 contributor: fullname: Lipsitz |
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Snippet | Background In patients affected by carotid sinus hypersensitivity, long-term vasodilator therapy might increase the risk of syncopal episodes by reducing... In patients affected by carotid sinus hypersensitivity, long-term vasodilator therapy might increase the risk of syncopal episodes by reducing systolic blood... |
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SubjectTerms | Aged Aged, 80 and over Biological and medical sciences Blood Pressure - drug effects Carotid Sinus - innervation Drug toxicity and drugs side effects treatment Female Heart Arrest - chemically induced Homeostasis - drug effects Humans Long-Term Care Male Massage Medical sciences Middle Aged Pharmacology. Drug treatments Pressoreceptors - drug effects Reflex, Abnormal - drug effects Risk Factors Syncope - chemically induced Syndrome Toxicity: cardiovascular system Vasodilator Agents - administration & dosage Vasodilator Agents - adverse effects Venous Pressure - drug effects |
Title | Effects of long-term vasodilator therapy in patients with carotid sinus hypersensitivity |
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