Pramel7 mediates ground-state pluripotency through proteasomal–epigenetic combined pathways

Naive pluripotency is established in preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of naive pluripotency. 2i culture has optimized this state, leading to a gene signature and DNA hypomethylation closely comparable to preimplantation epiblast, the developmental g...

Full description

Saved in:
Bibliographic Details
Published inNature cell biology Vol. 19; no. 7; pp. 763 - 773
Main Authors Graf, Urs, Casanova, Elisa A., Wyck, Sarah, Dalcher, Damian, Gatti, Marco, Vollenweider, Eva, Okoniewski, Michal J., Weber, Fabienne A., Patel, Sameera S., Schmid, Marc W., Li, Jiwen, Sharif, Jafar, Wanner, Guido A., Koseki, Haruhiko, Wong, Jiemin, Pelczar, Pawel, Penengo, Lorenza, Santoro, Raffaella, Cinelli, Paolo
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.07.2017
Nature Publishing Group
Subjects
13/100
13/51
38/111
38/47
38/88
38/91
631/136/2086
631/532/2064
631/532/2117
631/80/474/2085
Analysis
Animals
Antigens, Neoplasm - genetics
Antigens, Neoplasm - metabolism
Blastocyst - cytology
Blastocyst - enzymology
Cancer Research
Cell Biology
Cell culture
Cell regulation
Cullin Proteins - metabolism
Deoxyribonucleic acid
Developmental Biology
DNA
DNA Methylation
Embryo cells
Embryonic stem cells
Embryonic Stem Cells - enzymology
Embryos
Epigenesis, Genetic
Epigenetic inheritance
Gene expression
Gene Expression Regulation, Developmental
Ground state
HEK293 Cells
Humans
Immortalization
In vitro methods and tests
Life Sciences
Locks
Mice, Inbred C57BL
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Phenotype
Pluripotency
Pluripotent Stem Cells - enzymology
Proteasome Endopeptidase Complex - metabolism
Proteasomes
Protein Interaction Domains and Motifs
Protein Stability
Proteolysis
RNA Interference
Stem Cells
Time Factors
Transcriptome
Transfection
Ubiquitin-proteasome system
Switzerland
Online AccessGet full text

Cover

Abstract Naive pluripotency is established in preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of naive pluripotency. 2i culture has optimized this state, leading to a gene signature and DNA hypomethylation closely comparable to preimplantation epiblast, the developmental ground state. Here we show that Pramel7 (PRAME-like 7), a protein highly expressed in the inner cell mass (ICM) but expressed at low levels in ESCs, targets for proteasomal degradation UHRF1, a key factor for DNA methylation maintenance. Increasing Pramel7 expression in serum-cultured ESCs promotes a preimplantation epiblast-like gene signature, reduces UHRF1 levels and causes global DNA hypomethylation. Pramel7 is required for blastocyst formation and its forced expression locks ESCs in pluripotency. Pramel7/UHRF1 expression is mutually exclusive in ICMs whereas Pramel7-knockout embryos express high levels of UHRF1. Our data reveal an as-yet-unappreciated dynamic nature of DNA methylation through proteasome pathways and offer insights that might help to improve ESC culture to reproduce in vitro the in vivo ground-state pluripotency. Graf et al.  demonstrate that Pramel7 maintains ground-state pluripotency by repressing DNA methylation through proteasomal degradation of UHRF1, thus linking the proteasome and epigenetics with cell fate regulation.
AbstractList Naive pluripotency is established in preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of naive pluripotency. 2i culture has optimized this state, leading to a gene signature and DNA hypomethylation closely comparable to preimplantation epiblast, the developmental ground state. Here we show that Pramel7 (PRAME-like 7), a protein highly expressed in the inner cell mass (ICM) but expressed at low levels in ESCs, targets for proteasomal degradation UHRF1, a key factor for DNA methylation maintenance. Increasing Pramel7 expression in serum-cultured ESCs promotes a preimplantation epiblast-like gene signature, reduces UHRF1 levels and causes global DNA hypomethylation. Pramel7 is required for blastocyst formation and its forced expression locks ESCs in pluripotency. Pramel7/UHRF1 expression is mutually exclusive in ICMs whereas Pramel7-knockout embryos express high levels of UHRF1. Our data reveal an as-yet-unappreciated dynamic nature of DNA methylation through proteasome pathways and offer insights that might help to improve ESC culture to reproduce in vitro the in vivo ground-state pluripotency. Graf et al.  demonstrate that Pramel7 maintains ground-state pluripotency by repressing DNA methylation through proteasomal degradation of UHRF1, thus linking the proteasome and epigenetics with cell fate regulation.
Naive pluripotency is established in preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of naive pluripotency. 2i culture has optimized this state, leading to a gene signature and DNA hypomethylation closely comparable to preimplantation epiblast, the developmental ground state. Here we show that Pramel7 (PRAME-like 7), a protein highly expressed in the inner cell mass (ICM) but expressed at low levels in ESCs, targets for proteasomal degradation UHRF1, a key factor for DNA methylation maintenance. Increasing Pramel7 expression in serum-cultured ESCs promotes a preimplantation epiblast-like gene signature, reduces UHRF1 levels and causes global DNA hypomethylation. Pramel7 is required for blastocyst formation and its forced expression locks ESCs in pluripotency. Pramel7/UHRF1 expression is mutually exclusive in ICMs whereas Pramel7-knockout embryos express high levels of UHRF1. Our data reveal an as-yet-unappreciated dynamic nature of DNA methylation through proteasome pathways and offer insights that might help to improve ESC culture to reproduce in vitro the in vivo ground-state pluripotency.
Naive pluripotency is established in preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of naive pluripotency. 2i culture has optimized this state, leading to a gene signature and DNA hypomethylation closely comparable to preimplantation epiblast, the developmental ground state. Here we show that Pramel7 (PRAME-like 7), a protein highly expressed in the inner cell mass (ICM) but expressed at low levels in ESCs, targets for proteasomal degradation UHRF1, a key factor for DNA methylation maintenance. Increasing Pramel7 expression in serum-cultured ESCs promotes a preimplantation epiblast-like gene signature, reduces UHRF1 levels and causes global DNA hypomethylation. Pramel7 is required for blastocyst formation and its forced expression locks ESCs in pluripotency. Pramel7/UHRF1 expression is mutually exclusive in ICMs whereas Pramel7-knockout embryos express high levels of UHRF1. Our data reveal an as-yet-unappreciated dynamic nature of DNA methylation through proteasome pathways and offer insights that might help to improve ESC culture to reproduce in vitro the in vivo ground-state pluripotency.
Audience Academic
Author Casanova, Elisa A.
Koseki, Haruhiko
Pelczar, Pawel
Vollenweider, Eva
Patel, Sameera S.
Schmid, Marc W.
Wong, Jiemin
Okoniewski, Michal J.
Wanner, Guido A.
Li, Jiwen
Dalcher, Damian
Gatti, Marco
Sharif, Jafar
Cinelli, Paolo
Graf, Urs
Santoro, Raffaella
Penengo, Lorenza
Weber, Fabienne A.
Wyck, Sarah
Author_xml – sequence: 1
  givenname: Urs
  surname: Graf
  fullname: Graf, Urs
  organization: Department of Trauma Surgery, Center for Clinical Research, University Hospital Zurich, University of Zurich, Institute of Laboratory Animal Science, University of Zurich, Life Science Zurich Graduate School, University of Zurich
– sequence: 2
  givenname: Elisa A.
  surname: Casanova
  fullname: Casanova, Elisa A.
  organization: Department of Trauma Surgery, Center for Clinical Research, University Hospital Zurich, University of Zurich
– sequence: 3
  givenname: Sarah
  surname: Wyck
  fullname: Wyck, Sarah
  organization: Life Science Zurich Graduate School, University of Zurich, Department of Molecular Mechanisms of Disease, University of Zurich, Clinic of Reproductive Medicine, University of Zurich
– sequence: 4
  givenname: Damian
  surname: Dalcher
  fullname: Dalcher, Damian
  organization: Life Science Zurich Graduate School, University of Zurich, Department of Molecular Mechanisms of Disease, University of Zurich
– sequence: 5
  givenname: Marco
  surname: Gatti
  fullname: Gatti, Marco
  organization: Institute of Molecular Cancer Research, University of Zurich
– sequence: 6
  givenname: Eva
  surname: Vollenweider
  fullname: Vollenweider, Eva
  organization: Life Science Zurich Graduate School, University of Zurich, Department of Molecular Mechanisms of Disease, University of Zurich
– sequence: 7
  givenname: Michal J.
  surname: Okoniewski
  fullname: Okoniewski, Michal J.
  organization: Scientific IT Services
– sequence: 8
  givenname: Fabienne A.
  surname: Weber
  fullname: Weber, Fabienne A.
  organization: Institute of Laboratory Animal Science, University of Zurich, Life Science Zurich Graduate School, University of Zurich
– sequence: 9
  givenname: Sameera S.
  surname: Patel
  fullname: Patel, Sameera S.
  organization: Institute of Laboratory Animal Science, University of Zurich, Life Science Zurich Graduate School, University of Zurich
– sequence: 10
  givenname: Marc W.
  surname: Schmid
  fullname: Schmid, Marc W.
  organization: Service and Support for Science IT, University of Zurich
– sequence: 11
  givenname: Jiwen
  surname: Li
  fullname: Li, Jiwen
  organization: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University
– sequence: 12
  givenname: Jafar
  surname: Sharif
  fullname: Sharif, Jafar
  organization: Developmental Genetics Laboratory, RIKEN Center for Integrative Medical Sciences
– sequence: 13
  givenname: Guido A.
  surname: Wanner
  fullname: Wanner, Guido A.
  organization: Department of Trauma Surgery, Center for Clinical Research, University Hospital Zurich, University of Zurich
– sequence: 14
  givenname: Haruhiko
  surname: Koseki
  fullname: Koseki, Haruhiko
  organization: Developmental Genetics Laboratory, RIKEN Center for Integrative Medical Sciences
– sequence: 15
  givenname: Jiemin
  surname: Wong
  fullname: Wong, Jiemin
  organization: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University
– sequence: 16
  givenname: Pawel
  surname: Pelczar
  fullname: Pelczar, Pawel
  organization: Center for Transgenic Models, University of Basel
– sequence: 17
  givenname: Lorenza
  surname: Penengo
  fullname: Penengo, Lorenza
  organization: Institute of Molecular Cancer Research, University of Zurich
– sequence: 18
  givenname: Raffaella
  surname: Santoro
  fullname: Santoro, Raffaella
  email: raffaella.santoro@dmmd.uzh.ch
  organization: Department of Molecular Mechanisms of Disease, University of Zurich, Center for Applied Biotechnology and Molecular Medicine, University of Zurich
– sequence: 19
  givenname: Paolo
  surname: Cinelli
  fullname: Cinelli, Paolo
  email: paolo.cinelli@usz.ch
  organization: Department of Trauma Surgery, Center for Clinical Research, University Hospital Zurich, University of Zurich, Institute of Laboratory Animal Science, University of Zurich, Center for Applied Biotechnology and Molecular Medicine, University of Zurich
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28604677$$D View this record in MEDLINE/PubMed
BookMark eNpd0MtKxTAQBuAgind8Aym4UBfV5DRNmqWINxAUL0sJaTrpqbRpTVL07HwH39AnMXKOIq5ymY-Z4d9Ay7a3gNAOwUcEZ8Wx1WWW53QJrRPKWUoZF8vfd5anPBOTNbTh_TPGhFLMV9HapGA4Gr6Onm6d6qDlSQdVowL4pHb9aKvUh_hKhnZ0zdAHsHqWhGks1dNkcPFD-b5T7ef7BwxNDRZCoxPdd2VjoUoGFaavaua30IpRrYftxbmJHs_PHk4v0-ubi6vTk-tUUyxCmmOh8ESXhVKkrKAQzJS8FBnDJasMV4xyowylCoyhxDCmCRSY5ryCLAMD2Sbam_eNq72M4IN87kdn40hJBOGCFViQqA7nqlYtyMbq3gZ4C7UavZdX93fyhGUTTmnk0e7PrXa99w6MHFzTKTeTBMvvyOUi8ih3F7PHMob4634yjuBgDnws2Rrcn-X-9foCXeWOAQ
CitedBy_id crossref_primary_10_1016_j_tig_2019_06_005
crossref_primary_10_1093_nar_gkaa1154
crossref_primary_10_1002_mrd_23324
crossref_primary_10_1038_s41598_018_37258_3
crossref_primary_10_3390_genes13101745
crossref_primary_10_1038_s41467_018_04818_0
crossref_primary_10_1016_j_cmet_2018_11_007
crossref_primary_10_1016_j_molcel_2024_03_015
crossref_primary_10_1038_s44318_024_00086_5
crossref_primary_10_1016_j_celrep_2019_10_031
crossref_primary_10_1038_s44319_024_00083_z
crossref_primary_10_1186_s13578_021_00612_6
crossref_primary_10_1038_s41418_019_0359_9
crossref_primary_10_1242_dev_164772
crossref_primary_10_3724_abbs_2022080
crossref_primary_10_1016_j_semcancer_2018_08_006
crossref_primary_10_1093_nar_gkac230
crossref_primary_10_1242_dev_201907
crossref_primary_10_1186_s13578_024_01212_w
crossref_primary_10_1016_j_stemcr_2018_12_004
crossref_primary_10_1186_s12915_022_01251_0
crossref_primary_10_1016_j_celrep_2020_108315
crossref_primary_10_4103_1673_5374_219050
crossref_primary_10_1016_j_jgg_2021_01_006
crossref_primary_10_1016_j_stemcr_2020_06_018
crossref_primary_10_1080_15592294_2022_2044126
crossref_primary_10_1093_biolre_ioab074
Cites_doi 10.1016/j.stem.2010.03.015
10.1371/journal.pone.0052629
10.1016/j.cell.2013.12.001
10.1038/ncomms2562
10.1038/nature07249
10.1186/gb-2010-11-3-r25
10.1016/j.cub.2010.06.050
10.1016/j.cell.2012.03.026
10.1038/nature06397
10.1016/j.stem.2013.06.004
10.1038/415530a
10.1242/dev.01586
10.1046/j.1365-2141.1998.00982.x
10.1093/bioinformatics/btu170
10.1093/nar/gku365
10.1016/j.molcel.2016.04.025
10.1111/j.1365-2443.2006.00984.x
10.1016/j.stem.2016.03.013
10.1016/S1673-8527(09)60063-1
10.1098/rstb.2013.0540
10.1016/j.stem.2014.09.015
10.1006/dbio.1999.9265
10.1093/biostatistics/kxj037
10.1038/nature12488
10.1002/stem.588
10.1146/annurev.arplant.58.032806.104011
10.1038/292154a0
10.1038/nsmb.2510
10.1016/j.stem.2014.10.005
10.1093/bioinformatics/bts635
10.1016/j.molcel.2014.04.004
10.1242/dev.00366
10.1186/1471-213X-8-57
10.1007/s00018-016-2255-5
10.1083/jcb.200201025
10.1016/j.stem.2007.12.011
10.1242/dev.02880
10.1073/pnas.78.12.7634
10.1242/dev.02858
10.1038/nature10960
10.1186/s12896-016-0234-4
10.1242/dev.02787
10.1126/science.1147939
10.1016/S0959-440X(01)00266-4
10.1038/ncb2965
10.1038/nature06968
10.1016/j.bbrc.2009.09.131
10.1242/jcs.118273
10.1016/j.stem.2013.06.002
10.1016/S1074-7613(00)80426-4
ContentType Journal Article
Copyright Springer Nature Limited 2017
COPYRIGHT 2017 Nature Publishing Group
Copyright Nature Publishing Group Jul 2017
Copyright_xml – notice: Springer Nature Limited 2017
– notice: COPYRIGHT 2017 Nature Publishing Group
– notice: Copyright Nature Publishing Group Jul 2017
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
ISR
3V.
7QL
7QP
7QR
7T5
7TK
7TM
7TO
7U9
7X7
7XB
88A
88E
8AO
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7N
M7P
P64
PQEST
PQQKQ
PQUKI
RC3
DOI 10.1038/ncb3554
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Gale In Context: Science
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Immunology Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Virology and AIDS Abstracts
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
ProQuest Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
Genetics Abstracts
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
Technology Research Database
ProQuest Central Essentials
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
Environmental Sciences and Pollution Management
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
Genetics Abstracts
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Collection
AIDS and Cancer Research Abstracts
Chemoreception Abstracts
ProQuest Medical Library (Alumni)
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Immunology Abstracts
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest Central (Alumni)
DatabaseTitleList
MEDLINE

ProQuest Central Student
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1476-4679
EndPage 773
ExternalDocumentID A632744968
10_1038_ncb3554
28604677
Genre Journal Article
GeographicLocations Switzerland
GeographicLocations_xml – name: Switzerland
GroupedDBID ---
0R~
123
29M
36B
39C
3V.
4.4
53G
5BI
5RE
70F
7X7
88A
88E
8AO
8FE
8FH
8FI
8FJ
8R4
8R5
AAEEF
AARCD
AAZLF
ABCQX
ABJNI
ABLJU
ABUWG
ABVXF
ACGFS
ACIWK
ACNCT
ACPRK
ADBBV
ADQMX
AENEX
AFFNX
AFKRA
AFRAH
AFSHS
AFWHJ
AGAYW
AGEZK
AGHTU
AHBCP
AHMBA
AHOSX
AHSBF
AIBTJ
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ARMCB
ASPBG
AVWKF
AXYYD
AZFZN
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
CCPQU
CS3
D0L
DU5
EAP
EBS
EE.
EJD
EMB
ESX
EXGXG
F5P
FEDTE
FQGFK
FSGXE
FYUFA
HCIFZ
HMCUK
HVGLF
HZ~
IAO
IGS
IHR
INH
INR
ISR
ITC
L7B
LK8
M0L
M1P
M7P
N9A
NNMJJ
O9-
P2P
PQQKQ
PROAC
PSQYO
Q2X
RNS
RNT
RNTTT
SHXYY
SIXXV
SNYQT
TAOOD
TBHMF
TDRGL
TSG
UKHRP
~02
.55
.GJ
AAYZH
ABAWZ
ABDBF
ABEFU
AFBBN
AIYXT
B0M
CGR
CUY
CVF
DB5
EAD
EBC
EBD
ECM
EIF
EMK
EMOBN
EPL
J5H
L-9
NPM
ODYON
QF4
QM4
QN7
QO4
SKT
SV3
TUS
X7M
Y6R
ZGI
~8M
AAYXX
CITATION
AADEA
AAEXX
ABEEJ
ADZGE
7QL
7QP
7QR
7T5
7TK
7TM
7TO
7U9
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
M7N
P64
PQEST
PQUKI
RC3
ID FETCH-LOGICAL-c409t-509a02cb8aa1bde896fb7b9360b6df7a647faf44aeff41f66c1e80457de33efe3
IEDL.DBID BENPR
ISSN 1465-7392
IngestDate Sat Oct 26 05:53:41 EDT 2024
Thu Aug 01 19:47:56 EDT 2024
Thu Sep 26 18:03:39 EDT 2024
Wed Oct 16 00:50:29 EDT 2024
Fri Oct 11 20:45:44 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 7
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c409t-509a02cb8aa1bde896fb7b9360b6df7a647faf44aeff41f66c1e80457de33efe3
PMID 28604677
PQID 1917968091
PQPubID 45779
PageCount 11
ParticipantIDs proquest_journals_1917968091
gale_incontextgauss_ISR_A632744968
crossref_primary_10_1038_ncb3554
pubmed_primary_28604677
springer_journals_10_1038_ncb3554
PublicationCentury 2000
PublicationDate 2017-07-01
PublicationDateYYYYMMDD 2017-07-01
PublicationDate_xml – month: 07
  year: 2017
  text: 2017-07-01
  day: 01
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature cell biology
PublicationTitleAbbrev Nat Cell Biol
PublicationTitleAlternate Nat Cell Biol
PublicationYear 2017
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Martin (CR1) 1981; 78
Tsumura (CR45) 2006; 11
Tai, Ying (CR37) 2013; 126
Arita, Ariyoshi, Tochio, Nakamura, Shirakawa (CR28) 2008; 455
Niwa (CR4) 2007; 134
Smith (CR7) 2012; 484
Grice, Nathan (CR25) 2016; 73
Johnson, Li, Rabinovic (CR50) 2007; 8
Hotton, Callis (CR23) 2008; 59
Weidgang (CR39) 2013; 1
Bolger, Lohse, Usadel (CR47) 2014; 30
Kobe, Kajava (CR26) 2001; 11
Liu (CR22) 2013; 4
Fouse (CR40) 2008; 2
Sharif (CR41) 2016; 19
Huang, Qin (CR38) 2010; 37
Evans, Kaufman (CR2) 1981; 292
Hackett, Surani (CR6) 2014; 15
Ying (CR13) 2008; 453
Habibi (CR8) 2013; 13
Bonapace (CR35) 2002; 157
Kalkan, Smith (CR36) 2014; 369
Nishiyama (CR27) 2013; 502
Gelato (CR30) 2014; 54
Robinson, Oshlack (CR49) 2010; 11
Dobin (CR48) 2013; 29
Marks (CR12) 2012; 149
Casanova (CR15) 2011; 29
Chu (CR31) 2016; 16
Bortvin (CR14) 2003; 130
Sharif (CR20) 2007; 450
Chen (CR52) 2013; 155
Achour (CR29) 2009; 390
Burdon, Stracey, Chambers, Nichols, Smith (CR17) 1999; 210
van ’t Veer (CR44) 2002; 415
Tang (CR5) 2010; 6
Hermann, Cermak, Voytas, Pelczar (CR53) 2014; 86
Leitch (CR11) 2013; 20
Cinelli (CR16) 2008; 8
Ramirez, Dundar, Diehl, Gruning, Manke (CR46) 2014; 42
Boroviak, Loos, Bertone, Smith, Nichols (CR9) 2014; 16
Sakaue (CR33) 2010; 20
van Baren (CR42) 1998; 102
Ficz (CR10) 2013; 13
Bostick (CR21) 2007; 317
Schmidt (CR32) 2012; 7
von Meyenn (CR24) 2016; 62
Ikeda (CR43) 1997; 6
Kunath (CR18) 2007; 134
Le, Josse, Husson (CR51) 2008; 25
Stavridis, Lunn, Collins, Storey (CR19) 2007; 134
Zwaka, Thomson (CR3) 2005; 132
Savic (CR34) 2014; 15
28752849 - Nat Cell Biol. 2017 Jul 28;19(8):1003
VT Chu (BFncb3554_CR31) 2016; 16
J Sharif (BFncb3554_CR41) 2016; 19
N Savic (BFncb3554_CR34) 2014; 15
A Tsumura (BFncb3554_CR45) 2006; 11
B Chen (BFncb3554_CR52) 2013; 155
MP Stavridis (BFncb3554_CR19) 2007; 134
X Liu (BFncb3554_CR22) 2013; 4
M Sakaue (BFncb3554_CR33) 2010; 20
AM Bolger (BFncb3554_CR47) 2014; 30
MD Robinson (BFncb3554_CR49) 2010; 11
T Kunath (BFncb3554_CR18) 2007; 134
KA Gelato (BFncb3554_CR30) 2014; 54
E Habibi (BFncb3554_CR8) 2013; 13
CS Schmidt (BFncb3554_CR32) 2012; 7
GR Martin (BFncb3554_CR1) 1981; 78
LJ van ’t Veer (BFncb3554_CR44) 2002; 415
T Kalkan (BFncb3554_CR36) 2014; 369
M Hermann (BFncb3554_CR53) 2014; 86
S Le (BFncb3554_CR51) 2008; 25
B Kobe (BFncb3554_CR26) 2001; 11
G Ficz (BFncb3554_CR10) 2013; 13
F von Meyenn (BFncb3554_CR24) 2016; 62
T Boroviak (BFncb3554_CR9) 2014; 16
E Casanova (BFncb3554_CR15) 2011; 29
F Ramirez (BFncb3554_CR46) 2014; 42
T Burdon (BFncb3554_CR17) 1999; 210
M Bostick (BFncb3554_CR21) 2007; 317
N van Baren (BFncb3554_CR42) 1998; 102
ZD Smith (BFncb3554_CR7) 2012; 484
SD Fouse (BFncb3554_CR40) 2008; 2
J Sharif (BFncb3554_CR20) 2007; 450
HG Leitch (BFncb3554_CR11) 2013; 20
SK Hotton (BFncb3554_CR23) 2008; 59
CE Weidgang (BFncb3554_CR39) 2013; 1
TP Zwaka (BFncb3554_CR3) 2005; 132
F Tang (BFncb3554_CR5) 2010; 6
A Bortvin (BFncb3554_CR14) 2003; 130
H Marks (BFncb3554_CR12) 2012; 149
C Huang (BFncb3554_CR38) 2010; 37
GL Grice (BFncb3554_CR25) 2016; 73
JA Hackett (BFncb3554_CR6) 2014; 15
M Achour (BFncb3554_CR29) 2009; 390
A Dobin (BFncb3554_CR48) 2013; 29
H Ikeda (BFncb3554_CR43) 1997; 6
MJ Evans (BFncb3554_CR2) 1981; 292
IM Bonapace (BFncb3554_CR35) 2002; 157
QL Ying (BFncb3554_CR13) 2008; 453
WE Johnson (BFncb3554_CR50) 2007; 8
P Cinelli (BFncb3554_CR16) 2008; 8
CI Tai (BFncb3554_CR37) 2013; 126
K Arita (BFncb3554_CR28) 2008; 455
H Niwa (BFncb3554_CR4) 2007; 134
A Nishiyama (BFncb3554_CR27) 2013; 502
References_xml – volume: 6
  start-page: 468
  year: 2010
  end-page: 478
  ident: CR5
  article-title: Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-Seq analysis
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2010.03.015
  contributor:
    fullname: Tang
– volume: 7
  start-page: e52629
  year: 2012
  ident: CR32
  article-title: Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0052629
  contributor:
    fullname: Schmidt
– volume: 155
  start-page: 1479
  year: 2013
  end-page: 1491
  ident: CR52
  article-title: Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system
  publication-title: Cell
  doi: 10.1016/j.cell.2013.12.001
  contributor:
    fullname: Chen
– volume: 4
  start-page: 1563
  year: 2013
  ident: CR22
  article-title: UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms2562
  contributor:
    fullname: Liu
– volume: 455
  start-page: 818
  year: 2008
  end-page: 821
  ident: CR28
  article-title: Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism
  publication-title: Nature
  doi: 10.1038/nature07249
  contributor:
    fullname: Shirakawa
– volume: 11
  start-page: R25
  year: 2010
  ident: CR49
  article-title: A scaling normalization method for differential expression analysis of RNA-seq data
  publication-title: Genome Biol.
  doi: 10.1186/gb-2010-11-3-r25
  contributor:
    fullname: Oshlack
– volume: 20
  start-page: 1452
  year: 2010
  end-page: 1457
  ident: CR33
  article-title: DNA methylation is dispensable for the growth and survival of the extraembryonic lineages
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2010.06.050
  contributor:
    fullname: Sakaue
– volume: 149
  start-page: 590
  year: 2012
  end-page: 604
  ident: CR12
  article-title: The transcriptional and epigenomic foundations of ground state pluripotency
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.026
  contributor:
    fullname: Marks
– volume: 450
  start-page: 908
  year: 2007
  end-page: 912
  ident: CR20
  article-title: The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA
  publication-title: Nature
  doi: 10.1038/nature06397
  contributor:
    fullname: Sharif
– volume: 13
  start-page: 351
  year: 2013
  end-page: 359
  ident: CR10
  article-title: FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.06.004
  contributor:
    fullname: Ficz
– volume: 415
  start-page: 530
  year: 2002
  end-page: 536
  ident: CR44
  article-title: Gene expression profiling predicts clinical outcome of breast cancer
  publication-title: Nature
  doi: 10.1038/415530a
  contributor:
    fullname: van ’t Veer
– volume: 132
  start-page: 227
  year: 2005
  end-page: 233
  ident: CR3
  article-title: A germ cell origin of embryonic stem cells?
  publication-title: Development
  doi: 10.1242/dev.01586
  contributor:
    fullname: Thomson
– volume: 102
  start-page: 1376
  year: 1998
  end-page: 1379
  ident: CR42
  article-title: PRAME, a gene encoding an antigen recognized on a human melanoma by cytolytic T cells, is expressed in acute leukaemia cells
  publication-title: Br. J. Haematol.
  doi: 10.1046/j.1365-2141.1998.00982.x
  contributor:
    fullname: van Baren
– volume: 30
  start-page: 2114
  year: 2014
  end-page: 2120
  ident: CR47
  article-title: Trimmomatic: a flexible trimmer for Illumina sequence data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu170
  contributor:
    fullname: Usadel
– volume: 42
  start-page: W187
  year: 2014
  end-page: W191
  ident: CR46
  article-title: deepTools: a flexible platform for exploring deep-sequencing data
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku365
  contributor:
    fullname: Manke
– volume: 62
  start-page: 848
  year: 2016
  end-page: 861
  ident: CR24
  article-title: Impairment of DNA methylation maintenance is the main cause of global demethylation in naive embryonic stem cells
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2016.04.025
  contributor:
    fullname: von Meyenn
– volume: 11
  start-page: 805
  year: 2006
  end-page: 814
  ident: CR45
  article-title: Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b
  publication-title: Genes Cells
  doi: 10.1111/j.1365-2443.2006.00984.x
  contributor:
    fullname: Tsumura
– volume: 19
  start-page: 81
  year: 2016
  end-page: 94
  ident: CR41
  article-title: Activation of endogenous retroviruses in Dnmt1 ESCs involves disruption of SETDB1-mediated repression by NP95 binding to hemimethylated DNA
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2016.03.013
  contributor:
    fullname: Sharif
– volume: 37
  start-page: 441
  year: 2010
  end-page: 449
  ident: CR38
  article-title: Role of Lef1 in sustaining self-renewal in mouse embryonic stem cells
  publication-title: J. Genet. Genomics
  doi: 10.1016/S1673-8527(09)60063-1
  contributor:
    fullname: Qin
– volume: 86
  start-page: 50930
  year: 2014
  ident: CR53
  article-title: Mouse genome engineering using designer nucleases
  publication-title: J. Vis. Exp.
  contributor:
    fullname: Pelczar
– volume: 369
  start-page: 20130540
  year: 2014
  ident: CR36
  article-title: Mapping the route from naive pluripotency to lineage specification
  publication-title: Phil. Trans. R Soc. B
  doi: 10.1098/rstb.2013.0540
  contributor:
    fullname: Smith
– volume: 15
  start-page: 416
  year: 2014
  end-page: 430
  ident: CR6
  article-title: Regulatory principles of pluripotency: from the ground state up
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2014.09.015
  contributor:
    fullname: Surani
– volume: 210
  start-page: 30
  year: 1999
  end-page: 43
  ident: CR17
  article-title: Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells
  publication-title: Dev. Biol.
  doi: 10.1006/dbio.1999.9265
  contributor:
    fullname: Smith
– volume: 8
  start-page: 118
  year: 2007
  end-page: 127
  ident: CR50
  article-title: Adjusting batch effects in microarray expression data using empirical Bayes methods
  publication-title: Biostatistics
  doi: 10.1093/biostatistics/kxj037
  contributor:
    fullname: Rabinovic
– volume: 502
  start-page: 249
  year: 2013
  end-page: 253
  ident: CR27
  article-title: Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication
  publication-title: Nature
  doi: 10.1038/nature12488
  contributor:
    fullname: Nishiyama
– volume: 29
  start-page: 474
  year: 2011
  end-page: 485
  ident: CR15
  article-title: Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells
  publication-title: Stem Cells
  doi: 10.1002/stem.588
  contributor:
    fullname: Casanova
– volume: 59
  start-page: 467
  year: 2008
  end-page: 489
  ident: CR23
  article-title: Regulation of cullin RING ligases
  publication-title: Annu. Rev. Plant Biol.
  doi: 10.1146/annurev.arplant.58.032806.104011
  contributor:
    fullname: Callis
– volume: 292
  start-page: 154
  year: 1981
  end-page: 156
  ident: CR2
  article-title: Establishment in culture of pluripotential cells from mouse embryos
  publication-title: Nature
  doi: 10.1038/292154a0
  contributor:
    fullname: Kaufman
– volume: 20
  start-page: 311
  year: 2013
  end-page: 316
  ident: CR11
  article-title: Naive pluripotency is associated with global DNA hypomethylation
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2510
  contributor:
    fullname: Leitch
– volume: 15
  start-page: 720
  year: 2014
  end-page: 734
  ident: CR34
  article-title: lncRNA maturation to initiate heterochromatin formation in the nucleolus is required for exit from pluripotency in ESCs
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2014.10.005
  contributor:
    fullname: Savic
– volume: 29
  start-page: 15
  year: 2013
  end-page: 21
  ident: CR48
  article-title: STAR: ultrafast universal RNA-seq aligner
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts635
  contributor:
    fullname: Dobin
– volume: 54
  start-page: 905
  year: 2014
  end-page: 919
  ident: CR30
  article-title: Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2014.04.004
  contributor:
    fullname: Gelato
– volume: 130
  start-page: 1673
  year: 2003
  end-page: 1680
  ident: CR14
  article-title: Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei
  publication-title: Development
  doi: 10.1242/dev.00366
  contributor:
    fullname: Bortvin
– volume: 8
  start-page: 57
  year: 2008
  ident: CR16
  article-title: Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3
  publication-title: BMC Dev. Biol.
  doi: 10.1186/1471-213X-8-57
  contributor:
    fullname: Cinelli
– volume: 73
  start-page: 3497
  year: 2016
  end-page: 3506
  ident: CR25
  article-title: The recognition of ubiquitinated proteins by the proteasome
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-016-2255-5
  contributor:
    fullname: Nathan
– volume: 157
  start-page: 909
  year: 2002
  end-page: 914
  ident: CR35
  article-title: Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200201025
  contributor:
    fullname: Bonapace
– volume: 2
  start-page: 160
  year: 2008
  end-page: 169
  ident: CR40
  article-title: Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2007.12.011
  contributor:
    fullname: Fouse
– volume: 134
  start-page: 2895
  year: 2007
  end-page: 2902
  ident: CR18
  article-title: FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment
  publication-title: Development
  doi: 10.1242/dev.02880
  contributor:
    fullname: Kunath
– volume: 78
  start-page: 7634
  year: 1981
  end-page: 7638
  ident: CR1
  article-title: Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.78.12.7634
  contributor:
    fullname: Martin
– volume: 134
  start-page: 2889
  year: 2007
  end-page: 2894
  ident: CR19
  article-title: A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification
  publication-title: Development
  doi: 10.1242/dev.02858
  contributor:
    fullname: Storey
– volume: 1
  start-page: 248
  year: 2013
  end-page: 265
  ident: CR39
  article-title: TBX3 directs cell-fate decision toward mesendoderm
  publication-title: Stem Cell Rep.
  contributor:
    fullname: Weidgang
– volume: 484
  start-page: 339
  year: 2012
  end-page: 344
  ident: CR7
  article-title: A unique regulatory phase of DNA methylation in the early mammalian embryo
  publication-title: Nature
  doi: 10.1038/nature10960
  contributor:
    fullname: Smith
– volume: 16
  start-page: 4
  year: 2016
  ident: CR31
  article-title: Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes
  publication-title: BMC Biotechnol.
  doi: 10.1186/s12896-016-0234-4
  contributor:
    fullname: Chu
– volume: 134
  start-page: 635
  year: 2007
  end-page: 646
  ident: CR4
  article-title: How is pluripotency determined and maintained?
  publication-title: Development
  doi: 10.1242/dev.02787
  contributor:
    fullname: Niwa
– volume: 317
  start-page: 1760
  year: 2007
  end-page: 1764
  ident: CR21
  article-title: UHRF1 plays a role in maintaining DNA methylation in mammalian cells
  publication-title: Science
  doi: 10.1126/science.1147939
  contributor:
    fullname: Bostick
– volume: 11
  start-page: 725
  year: 2001
  end-page: 732
  ident: CR26
  article-title: The leucine-rich repeat as a protein recognition motif
  publication-title: Curr. Opin. Struct. Biol.
  doi: 10.1016/S0959-440X(01)00266-4
  contributor:
    fullname: Kajava
– volume: 16
  start-page: 516
  year: 2014
  end-page: 528
  ident: CR9
  article-title: The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2965
  contributor:
    fullname: Nichols
– volume: 25
  start-page: 1
  year: 2008
  end-page: 18
  ident: CR51
  article-title: FactoMineR: an R package for multivariate analysis
  publication-title: J. Stat. Softw.
  contributor:
    fullname: Husson
– volume: 453
  start-page: 519
  year: 2008
  end-page: 523
  ident: CR13
  article-title: The ground state of embryonic stem cell self-renewal
  publication-title: Nature
  doi: 10.1038/nature06968
  contributor:
    fullname: Ying
– volume: 390
  start-page: 523
  year: 2009
  end-page: 528
  ident: CR29
  article-title: UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2009.09.131
  contributor:
    fullname: Achour
– volume: 126
  start-page: 1093
  year: 2013
  end-page: 1098
  ident: CR37
  article-title: Gbx2, a LIF/Stat3 target, promotes reprogramming to and retention of the pluripotent ground state
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.118273
  contributor:
    fullname: Ying
– volume: 13
  start-page: 360
  year: 2013
  end-page: 369
  ident: CR8
  article-title: Whole-genome bisulfite sequencing of two distinct interconvertible DNA methylomes of mouse embryonic stem cells
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.06.002
  contributor:
    fullname: Habibi
– volume: 6
  start-page: 199
  year: 1997
  end-page: 208
  ident: CR43
  article-title: Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80426-4
  contributor:
    fullname: Ikeda
– volume: 134
  start-page: 635
  year: 2007
  ident: BFncb3554_CR4
  publication-title: Development
  doi: 10.1242/dev.02787
  contributor:
    fullname: H Niwa
– volume: 62
  start-page: 848
  year: 2016
  ident: BFncb3554_CR24
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2016.04.025
  contributor:
    fullname: F von Meyenn
– volume: 210
  start-page: 30
  year: 1999
  ident: BFncb3554_CR17
  publication-title: Dev. Biol.
  doi: 10.1006/dbio.1999.9265
  contributor:
    fullname: T Burdon
– volume: 42
  start-page: W187
  year: 2014
  ident: BFncb3554_CR46
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku365
  contributor:
    fullname: F Ramirez
– volume: 30
  start-page: 2114
  year: 2014
  ident: BFncb3554_CR47
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu170
  contributor:
    fullname: AM Bolger
– volume: 132
  start-page: 227
  year: 2005
  ident: BFncb3554_CR3
  publication-title: Development
  doi: 10.1242/dev.01586
  contributor:
    fullname: TP Zwaka
– volume: 317
  start-page: 1760
  year: 2007
  ident: BFncb3554_CR21
  publication-title: Science
  doi: 10.1126/science.1147939
  contributor:
    fullname: M Bostick
– volume: 29
  start-page: 15
  year: 2013
  ident: BFncb3554_CR48
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts635
  contributor:
    fullname: A Dobin
– volume: 484
  start-page: 339
  year: 2012
  ident: BFncb3554_CR7
  publication-title: Nature
  doi: 10.1038/nature10960
  contributor:
    fullname: ZD Smith
– volume: 390
  start-page: 523
  year: 2009
  ident: BFncb3554_CR29
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2009.09.131
  contributor:
    fullname: M Achour
– volume: 59
  start-page: 467
  year: 2008
  ident: BFncb3554_CR23
  publication-title: Annu. Rev. Plant Biol.
  doi: 10.1146/annurev.arplant.58.032806.104011
  contributor:
    fullname: SK Hotton
– volume: 86
  start-page: 50930
  year: 2014
  ident: BFncb3554_CR53
  publication-title: J. Vis. Exp.
  contributor:
    fullname: M Hermann
– volume: 15
  start-page: 416
  year: 2014
  ident: BFncb3554_CR6
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2014.09.015
  contributor:
    fullname: JA Hackett
– volume: 1
  start-page: 248
  year: 2013
  ident: BFncb3554_CR39
  publication-title: Stem Cell Rep.
  contributor:
    fullname: CE Weidgang
– volume: 292
  start-page: 154
  year: 1981
  ident: BFncb3554_CR2
  publication-title: Nature
  doi: 10.1038/292154a0
  contributor:
    fullname: MJ Evans
– volume: 13
  start-page: 360
  year: 2013
  ident: BFncb3554_CR8
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.06.002
  contributor:
    fullname: E Habibi
– volume: 37
  start-page: 441
  year: 2010
  ident: BFncb3554_CR38
  publication-title: J. Genet. Genomics
  doi: 10.1016/S1673-8527(09)60063-1
  contributor:
    fullname: C Huang
– volume: 155
  start-page: 1479
  year: 2013
  ident: BFncb3554_CR52
  publication-title: Cell
  doi: 10.1016/j.cell.2013.12.001
  contributor:
    fullname: B Chen
– volume: 149
  start-page: 590
  year: 2012
  ident: BFncb3554_CR12
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.026
  contributor:
    fullname: H Marks
– volume: 369
  start-page: 20130540
  year: 2014
  ident: BFncb3554_CR36
  publication-title: Phil. Trans. R Soc. B
  doi: 10.1098/rstb.2013.0540
  contributor:
    fullname: T Kalkan
– volume: 6
  start-page: 199
  year: 1997
  ident: BFncb3554_CR43
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80426-4
  contributor:
    fullname: H Ikeda
– volume: 73
  start-page: 3497
  year: 2016
  ident: BFncb3554_CR25
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-016-2255-5
  contributor:
    fullname: GL Grice
– volume: 15
  start-page: 720
  year: 2014
  ident: BFncb3554_CR34
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2014.10.005
  contributor:
    fullname: N Savic
– volume: 11
  start-page: R25
  year: 2010
  ident: BFncb3554_CR49
  publication-title: Genome Biol.
  doi: 10.1186/gb-2010-11-3-r25
  contributor:
    fullname: MD Robinson
– volume: 54
  start-page: 905
  year: 2014
  ident: BFncb3554_CR30
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2014.04.004
  contributor:
    fullname: KA Gelato
– volume: 2
  start-page: 160
  year: 2008
  ident: BFncb3554_CR40
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2007.12.011
  contributor:
    fullname: SD Fouse
– volume: 20
  start-page: 311
  year: 2013
  ident: BFncb3554_CR11
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2510
  contributor:
    fullname: HG Leitch
– volume: 130
  start-page: 1673
  year: 2003
  ident: BFncb3554_CR14
  publication-title: Development
  doi: 10.1242/dev.00366
  contributor:
    fullname: A Bortvin
– volume: 78
  start-page: 7634
  year: 1981
  ident: BFncb3554_CR1
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.78.12.7634
  contributor:
    fullname: GR Martin
– volume: 29
  start-page: 474
  year: 2011
  ident: BFncb3554_CR15
  publication-title: Stem Cells
  doi: 10.1002/stem.588
  contributor:
    fullname: E Casanova
– volume: 11
  start-page: 805
  year: 2006
  ident: BFncb3554_CR45
  publication-title: Genes Cells
  doi: 10.1111/j.1365-2443.2006.00984.x
  contributor:
    fullname: A Tsumura
– volume: 6
  start-page: 468
  year: 2010
  ident: BFncb3554_CR5
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2010.03.015
  contributor:
    fullname: F Tang
– volume: 415
  start-page: 530
  year: 2002
  ident: BFncb3554_CR44
  publication-title: Nature
  doi: 10.1038/415530a
  contributor:
    fullname: LJ van ’t Veer
– volume: 134
  start-page: 2895
  year: 2007
  ident: BFncb3554_CR18
  publication-title: Development
  doi: 10.1242/dev.02880
  contributor:
    fullname: T Kunath
– volume: 102
  start-page: 1376
  year: 1998
  ident: BFncb3554_CR42
  publication-title: Br. J. Haematol.
  doi: 10.1046/j.1365-2141.1998.00982.x
  contributor:
    fullname: N van Baren
– volume: 25
  start-page: 1
  year: 2008
  ident: BFncb3554_CR51
  publication-title: J. Stat. Softw.
  contributor:
    fullname: S Le
– volume: 19
  start-page: 81
  year: 2016
  ident: BFncb3554_CR41
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2016.03.013
  contributor:
    fullname: J Sharif
– volume: 157
  start-page: 909
  year: 2002
  ident: BFncb3554_CR35
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200201025
  contributor:
    fullname: IM Bonapace
– volume: 4
  start-page: 1563
  year: 2013
  ident: BFncb3554_CR22
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms2562
  contributor:
    fullname: X Liu
– volume: 16
  start-page: 4
  year: 2016
  ident: BFncb3554_CR31
  publication-title: BMC Biotechnol.
  doi: 10.1186/s12896-016-0234-4
  contributor:
    fullname: VT Chu
– volume: 16
  start-page: 516
  year: 2014
  ident: BFncb3554_CR9
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2965
  contributor:
    fullname: T Boroviak
– volume: 502
  start-page: 249
  year: 2013
  ident: BFncb3554_CR27
  publication-title: Nature
  doi: 10.1038/nature12488
  contributor:
    fullname: A Nishiyama
– volume: 450
  start-page: 908
  year: 2007
  ident: BFncb3554_CR20
  publication-title: Nature
  doi: 10.1038/nature06397
  contributor:
    fullname: J Sharif
– volume: 134
  start-page: 2889
  year: 2007
  ident: BFncb3554_CR19
  publication-title: Development
  doi: 10.1242/dev.02858
  contributor:
    fullname: MP Stavridis
– volume: 8
  start-page: 57
  year: 2008
  ident: BFncb3554_CR16
  publication-title: BMC Dev. Biol.
  doi: 10.1186/1471-213X-8-57
  contributor:
    fullname: P Cinelli
– volume: 13
  start-page: 351
  year: 2013
  ident: BFncb3554_CR10
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.06.004
  contributor:
    fullname: G Ficz
– volume: 453
  start-page: 519
  year: 2008
  ident: BFncb3554_CR13
  publication-title: Nature
  doi: 10.1038/nature06968
  contributor:
    fullname: QL Ying
– volume: 11
  start-page: 725
  year: 2001
  ident: BFncb3554_CR26
  publication-title: Curr. Opin. Struct. Biol.
  doi: 10.1016/S0959-440X(01)00266-4
  contributor:
    fullname: B Kobe
– volume: 20
  start-page: 1452
  year: 2010
  ident: BFncb3554_CR33
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2010.06.050
  contributor:
    fullname: M Sakaue
– volume: 455
  start-page: 818
  year: 2008
  ident: BFncb3554_CR28
  publication-title: Nature
  doi: 10.1038/nature07249
  contributor:
    fullname: K Arita
– volume: 7
  start-page: e52629
  year: 2012
  ident: BFncb3554_CR32
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0052629
  contributor:
    fullname: CS Schmidt
– volume: 126
  start-page: 1093
  year: 2013
  ident: BFncb3554_CR37
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.118273
  contributor:
    fullname: CI Tai
– volume: 8
  start-page: 118
  year: 2007
  ident: BFncb3554_CR50
  publication-title: Biostatistics
  doi: 10.1093/biostatistics/kxj037
  contributor:
    fullname: WE Johnson
SSID ssj0014407
Score 2.4438264
Snippet Naive pluripotency is established in preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of naive pluripotency. 2i culture has...
SourceID proquest
gale
crossref
pubmed
springer
SourceType Aggregation Database
Index Database
Publisher
StartPage 763
SubjectTerms 13/100
13/51
38/111
38/47
38/88
38/91
631/136/2086
631/532/2064
631/532/2117
631/80/474/2085
Analysis
Animals
Antigens, Neoplasm - genetics
Antigens, Neoplasm - metabolism
Blastocyst - cytology
Blastocyst - enzymology
Cancer Research
Cell Biology
Cell culture
Cell regulation
Cullin Proteins - metabolism
Deoxyribonucleic acid
Developmental Biology
DNA
DNA Methylation
Embryo cells
Embryonic stem cells
Embryonic Stem Cells - enzymology
Embryos
Epigenesis, Genetic
Epigenetic inheritance
Gene expression
Gene Expression Regulation, Developmental
Ground state
HEK293 Cells
Humans
Immortalization
In vitro methods and tests
Life Sciences
Locks
Mice, Inbred C57BL
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Phenotype
Pluripotency
Pluripotent Stem Cells - enzymology
Proteasome Endopeptidase Complex - metabolism
Proteasomes
Protein Interaction Domains and Motifs
Protein Stability
Proteolysis
RNA Interference
Stem Cells
Time Factors
Transcriptome
Transfection
Ubiquitin-proteasome system
Title Pramel7 mediates ground-state pluripotency through proteasomal–epigenetic combined pathways
URI https://link.springer.com/article/10.1038/ncb3554
https://www.ncbi.nlm.nih.gov/pubmed/28604677
https://www.proquest.com/docview/1917968091
Volume 19
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Nb9QwEB3RrZC4IL4JLZVBXK1mY8eOT1VBrQqHqipUWolDZMc2lyW7bXaF9t8z43hL2wN324lmkpk3npk3AJ-0iLaTdc07jD44Wr-am2oquBVNp0pnjHOp2uJcnV3Jb7N6li_chlxWubWJyVD7RUd35IcUVxjVoHs7Wl5zmhpF2dU8QmMHdiuMFKoJ7H4-Ob-4vM0jSJkaptEc1FwjFBjbZokU_LDvHPnae_7ooVW-45Ye5EmT-zl9Bk8zbmTHo6Kfw6PQv4DH4yTJzUv4eUFFVnPNUicIwkdG7Rq956lhiC3nazQOC8LHG5ZH87BE0WCHxW8752FJrJzU0MhQHBgtB89oWPEfuxlewdXpyY8vZzzPTeAdRmsrjhjAllXnGmunzofGqOi0MwJlr3zUVkkdbZTShhjlNCrVTUOD0E77IESIQbyGSb_ow1tgiF9qRDSNwRVSGm-EDVb5qoxl6fHwAthWeu1ypMdoU1pbNG0WcAEfSaotkU30VM3yy66Hof36_bI9VoIIClGtBexvZd7mn2ho_6m8gDejHm4fUjUKI3utC_iwVcydjfff4N3_D9-DJxX56lSDuw-T1c06vEeksXIHsKNn-iB_VH8BDFnUZA
link.rule.ids 315,783,787,12070,21402,27938,27939,31733,33758,43324,43819,74081,74638
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9QwDLZgE2IviPFrHWMExGu0XtMmzROaENMNxoRgk07iIUqaZC9H77beabr_HjvtjW0Pe0_Sym7tz7H9GeCTEtE2ZVXxBqMPjtav4roYCW5F3cjcae1cqrY4lePz8tukmgwXbt1QVrm2iclQ-1lDd-QHFFdoWaN7-zy_5DQ1irKrwwiNx7BJPFzEna8mNwEX5S1V311UcYVAoG-aJUrwg7Zx5GnveKP7NvmWU7qXJU3O5-g5PBtQIzvs1bwNj0L7Ap70cyRXL-HPTyqxmiqW-kAQPDJq1mg9T-1CbD5dommYETpesWEwD0sEDbab_bVTHubEyUntjAyFgbFy8IxGFV_bVfcKzo--nn0Z82FqAm8wVltwRAA2LxpXWztyPtRaRqecFih56aOyslTRxrK0IcZyFKVsRqFGYKd8ECLEIF7DRjtrww4wRC8V4pla44qy1F4LG6z0RR7z3OPhGbC19My8J8cwKaktajMIOIOPJFVDVBMt1bJc2GXXmePfv8yhFERPiErNYG8tczP8Qp35r_AM3vR6uHlIUUuM65XK4MNaMbc23n2D3YcPfw9Px2c_TszJ8en3t7BVkNdO1bh7sLG4WoZ3iDkWbj99WP8AlvHVCA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5BEagXxJtAAYO4WpuNHTs-oQpYtYCqCqi0EgfLjm0uS3ZLdoX23zPjZEvbA_fEieabzHyTeQG81SK5VtY1bzH64Gj9am6qqeBONK0qvTHe52qLE3V0Jj_N6_lY_9SPZZU7m5gNdVi29I98QnGFUQ26t0kayyJOP8zerc45bZCiTOu4TuMm3NISHR3qtp5fBF-Uw9RDp1HNNZKCoYGWxoNPutaT173ima7b50sO6lrGNDui2T24OzJIdjhAfh9uxO4B3B52Sm4fwo9TKrdaaJZ7QpBIMmrc6ALPrUNstdigmVgSU96ycUkPy8MaXL_85RY8rmg-J7U2MhQMxs0xMFpb_Mdt-0dwNvv4_f0RHzco8BbjtjVHNuDKqvWNc1MfYmNU8tobgSiokLRTUieXpHQxJTlNSrXT2CDJ0yEKEVMUj2GvW3bxKTBkMjVym8bgFVKaYISLToWqTGUZ8PAC2E56djUMyrA5wS0aOwq4gDckVUtjJzoC8Kfb9L09_vbVHipBowoR4AIOdjK34-fU23_gF_BkwOHiIVWjMMbXuoDXO2Au3Xj1DZ79__BXcAd1yn45Pvn8HPYrcuC5MPcA9ta_N_EF0o-1f5n16i9petk9
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pramel7+mediates+ground-state+pluripotency+through+proteasomal-epigenetic+combined+pathways&rft.jtitle=Nature+cell+biology&rft.au=Graf%2C+Urs&rft.au=Casanova%2C+Elisa+A&rft.au=Wyck%2C+Sarah&rft.au=Dalcher%2C+Damian&rft.date=2017-07-01&rft.pub=Nature+Publishing+Group&rft.issn=1465-7392&rft.eissn=1476-4679&rft.volume=19&rft.issue=7&rft.spage=763&rft_id=info:doi/10.1038%2Fncb3554&rft.externalDBID=ISR&rft.externalDocID=A632744968
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1465-7392&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1465-7392&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1465-7392&client=summon