In situ metabolic and hemodynamic response to dexfenfluramine in white adipose tissue of rats

• Published in: Annals of nutrition and metabolism Vol. 45; no. 1; p. 24
• Main Authors: Boschmann, M, Adams, F, Klaus, S
• Format: Journal Article
• Language: English
• Published: Switzerland 2001
• Subjects: Adipose Tissue - blood supply; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Adrenergic beta-Agonists - pharmacology; Animals; Dexfenfluramine - pharmacology; Glycolysis - drug effects; Isoproterenol - pharmacology; Lactic Acid - biosynthesis; Lipolysis - drug effects; Male; Microdialysis; Nitroprusside - pharmacology; Obesity - drug therapy; Perfusion; Rats; Rats, Wistar; Regional Blood Flow - drug effects; Serotonin Receptor Agonists - pharmacology; Vasodilator Agents - pharmacology

Serotonergic neurons are included in the regulation of eating behavior and energy metabolism. Dexfenfluramine (DF), a serotonin releaser and reuptake inhibitor, is known to reduce food intake and body weight and to improve the metabolic profile of obese subjects with and without metabolic complicati...