Role of urinary cathepsin B and L in the detection of bladder urothelial cell carcinoma

• Published in: The Journal of urology Vol. 179; no. 2; p. 478
• Main Authors: Svatek, Robert S, Karam, Jose, Karakiewicz, Pierre I, Gallina, Andrea, Casella, Roberto, Roehrborn, Claus G, Shariat, Shahrokh F
• Format: Journal Article
• Language: English
• Published: United States 01.02.2008
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - urine; Carcinoma - pathology; Carcinoma - urine; Case-Control Studies; Cathepsin B - urine; Cathepsin L; Cathepsins - urine; Cysteine Endopeptidases - urine; Female; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Predictive Value of Tests; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - urine; Urothelium

We tested the hypothesis that urinary cathepsin B and L are associated with bladder cancer recurrence and invasiveness in patients with a history of nonmuscle invasive urothelial carcinoma of the bladder. Cathepsin B and L, and NMP22 were determined in the urine specimens of 188 consecutive subjects...