Aminophylline increases parasternal intercostal muscle activity during hypoxia in humans

• Published in: Respiratory physiology & neurobiology Vol. 161; no. 1; pp. 69 - 75
• Main Authors: Nishii, Y, Okada, Y, Yokoba, M, Katagiri, M, Yanaihara, T, Masuda, N, Easton, P.A, Abe, T
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 20.03.2008
• Subjects: Adult; Aminophylline; Aminophylline - pharmacology; Bronchodilator Agents - pharmacology; Control of breathing; Electromyography; Humans; Hypoxia - drug therapy; Hypoxic ventilatory response; Intercostal Muscles - drug effects; Intercostal Muscles - innervation; Male; Medical Education; Parasternal intercostal muscle; Pulmonary Ventilation - drug effects; Pulmonary/Respiratory; Respiratory Function Tests; Respiratory muscle; Tidal Volume - drug effects; Electromyography; Respiratory muscle; Control of breathing; Hypoxic ventilatory response; Aminophylline; Parasternal intercostal muscle

Abstract To clarify the mechanism of action of aminophylline on the hypoxic ventilatory response in humans, we analyzed the effects of aminophylline on respiratory neural output. To evaluate the respiratory neural output, we analyzed the electromyogram (EMG) of the parasternal intercostal muscle, on...