Ellagic Acid Combined with Tacrolimus Showed Synergistic Cell Growth Inhibition in Fission Yeast

• Published in: Biocontrol Science Vol. 27; no. 1; pp. 31 - 39
• Main Authors: HAGIHARA, KANAKO, HOSONAKA, KOUSUKE, HOSHINO, SHUHEI, IWATA, KAZUKI, OGAWA, NAOKI, SATOH, RYOSUKE, TAKASAKI, TERUAKI, MAEDA, TAKUYA, SUGIURA, REIKO
• Format: Journal Article
• Language: English
• Published: Japan The Society for Antibacterial and Antifungal Agents, Japan 01.01.2022; Japan Science and Technology Agency
• Subjects: Antifungal therapy; Apoptosis; Calcineurin; Calcineurin - metabolism; Calcineurin - pharmacology; Calcineurin inhibitors; Calcineurin Inhibitors - metabolism; Calcineurin Inhibitors - pharmacology; Calcium ions; Calcium-binding protein; Calmodulin; Cells; Clonal deletion; Defects; Deletion; Drugs; Ellagic acid; Ellagic Acid - metabolism; Ellagic Acid - pharmacology; Fission; Fungi; Fungicides; Growth; Humans; Hypertrophy; Immunoregulation; Immunosuppressive agents; Inhibition; Inhibitors; Lethality; Micafungin; Miconazole; Pathogens; Phosphatase; Protein phosphatase; Schizosaccharomyces - metabolism; Sensitivity enhancement; Survival; Synthetic lethality; Tacrolimus; Tacrolimus - metabolism; Tacrolimus - pharmacology; Transcription; Valproic acid; Virulence; Yeast; Yeasts; Antifungal therapy; Synthetic lethality; Tacrolimus; Calcineurin; Ellagic acid

Calcineurin (CN) is a conserved Ca2+-calmodulin activated protein phosphatase, which plays important roles in immune regulation, cardiac hypertrophy, and apoptosis in humans. In pathogenic fungi, CN is essential for stress survival, sexual development, and virulence. The immunosuppressant tacrolimus...