Concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma: A treatment paradigm also applicable to patients in Southeast Asia

• Published in: Cancer treatment reviews Vol. 35; no. 4; pp. 345 - 353
• Main Authors: Lu, Heming, Peng, Luxing, Yuan, Xianbin, Hao, Yanrong, Lu, Zhiping, Chen, Jiaxin, Cheng, Jinjian, Deng, Shan, Gu, Junzhao, Pang, Qiang, Qin, Jian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2009
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Asia, Southeastern; Carcinoma - mortality; Carcinoma - pathology; Carcinoma - therapy; Chemotherapy, Adjuvant; Combined Modality Therapy; Concurrent chemoradiotherapy; Female; Follow-Up Studies; Hematology, Oncology and Palliative Medicine; Humans; Image-guided radiotherapy; Immunotherapy; Immunotherapy - methods; Intensity-modulated radiotherapy; Locally advanced disease; Male; Nasopharyngeal carcinoma; Nasopharyngeal Neoplasms - mortality; Nasopharyngeal Neoplasms - pathology; Nasopharyngeal Neoplasms - therapy; Neoplasm Invasiveness - pathology; Neoplasm Staging; Radiotherapy Dosage; Radiotherapy, Adjuvant; Radiotherapy, Conformal; Radiotherapy, Intensity-Modulated; Randomized Controlled Trials as Topic; Risk Assessment; Survival Rate; Targeted therapy; Treatment Outcome; Asia, Southeastern; Nasopharyngeal carcinoma; Locally advanced disease; Image-guided radiotherapy; Targeted therapy; Concurrent chemoradiotherapy; Immunotherapy; Intensity-modulated radiotherapy

Summary The majority of nasopharyngeal carcinoma (NPC) patients present at locally advanced stage. The poor prognosis has led to increasing interests in exploring the use of chemotherapy (CT). Intergroup-0099 trial was the first randomized trial comparing concurrent chemoradiotherapy (CCRT) with rad...