Nigella sativa (Black Seed) as a Natural Remedy against Viruses

The currently available antiviral agents are associated with serious adverse effects, coupled with the increasing rate of viral resistance to the existing antiviral drugs. Hence, the search for alternative natural remedies is gaining momentum across the globe. Nigella sativa Linnen, also called Blac...

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Published inJournal of pure & applied microbiology : an international research journal of microbiology Vol. 15; no. 1; pp. 29 - 41
Main Authors Basurra, Rasha Saleh, Wang, Seok Mui, Alhoot, Mohammed Abdelfatah
Format Journal Article
LanguageEnglish
Published Oriental Scientific Publishing Company 01.03.2021
Journal of Pure and Applied Microbiology
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Abstract The currently available antiviral agents are associated with serious adverse effects, coupled with the increasing rate of viral resistance to the existing antiviral drugs. Hence, the search for alternative natural remedies is gaining momentum across the globe. Nigella sativa Linnen, also called Black seed, is a medicinal plant that is gaining worldwide recognition and has been extensively investigated. The present work is aimed to review the existing literature on the antiviral efficacy of Nigella sativa extracts (oil & bioactive compounds). The findings reveal that numerous articles have been published on Nigella sativa and its beneficial effects against different kinds of diseases. However, the antiviral efficacy of Nigella sativa is yet to be given the proper research attention it deserves.
AbstractList The currently available antiviral agents are associated with serious adverse effects, coupled with the increasing rate of viral resistance to the existing antiviral drugs. Hence, the search for alternative natural remedies is gaining momentum across the globe. Nigella sativa Linnen, also called Black seed, is a medicinal plant that is gaining worldwide recognition and has been extensively investigated. The present work is aimed to review the existing literature on the antiviral efficacy of Nigella sativa extracts (oil & bioactive compounds). The findings reveal that numerous articles have been published on Nigella sativa and its beneficial effects against different kinds of diseases. However, the antiviral efficacy of Nigella sativa is yet to be given the proper research attention it deserves.
The currently available antiviral agents are associated with serious adverse effects, coupled with the increasing rate of viral resistance to the existing antiviral drugs. Hence, the search for alternative natural remedies is gaining momentum across the globe. Nigella sativa Linnen, also called black seed, is a medicinal plant that is gaining worldwide recognition and has been extensively investigated. The present work is aimed to review the existing literature on the antiviral efficacy of Nigella sativa extracts (oil and bioactive compounds). The findings reveal that numerous articles have been published on Nigella sativa and its beneficial effects against different kinds of diseases. However, the antiviral efficacy of Nigella sativa is yet to be given the proper research attention it deserves.
The currently available antiviral agents are associated with serious adverse effects, coupled with the increasing rate of viral resistance to the existing antiviral drugs. Hence, the search for alternative natural remedies is gaining momentum across the globe. Nigella sativa Linnen, also called black seed, is a medicinal plant that is gaining worldwide recognition and has been extensively investigated. The present work is aimed to review the existing literature on the antiviral efficacy of Nigella sativa extracts (oil and bioactive compounds). The findings reveal that numerous articles have been published on Nigella sativa and its beneficial effects against different kinds of diseases. However, the antiviral efficacy of Nigella sativa is yet to be given the proper research attention it deserves. Keywords: Nigella sativa, Black seed, Antiviral activity, Viruses, Natural remedy
Audience Academic
Author Wang, Seok Mui
Alhoot, Mohammed Abdelfatah
Basurra, Rasha Saleh
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Cites_doi 10.1089/acu.2016.1204
10.5772/26946
10.5897/AJMR11.009
10.1038/nrgastro.2013.107
10.1080/10942912.2017.1371189
10.4103/pm.pm_108_18
10.1007/s13318-014-0207-8
10.3390/md10122795
10.1016/S0192-0561(00)00036-9
10.1111/j.1364-3703.2011.00752.x
10.1084/jem.54.6.817
10.1016/j.onehlt.2020.100123
10.1016/j.bcp.2011.09.029
10.1016/j.jssas.2016.09.004
10.3390/v4113044
10.1016/S2221-1691(13)60075-1
10.1016/j.hermed.2013.04.006
10.1080/01652176.2013.782119
10.1016/bs.aivir.2016.08.001
10.1016/j.jep.2015.09.022
10.21475/ajcs.17.11.12.pne709
10.4314/ajid.v9i2.6
10.1371/journal.pone.0140765
10.3389/fphar.2017.00656
10.1016/S0140-6736(20)30211-7
10.1055/s-2006-957994
10.1016/S0378-8741(01)00342-7
10.5501/wjv.v1.i5.142
10.1142/S0192415X1100941X
10.1002/ptr.1390
10.3389/fcell.2020.00646
10.3382/ps/pew069
10.1017/S0043933917000848
10.1177/1040638711407887
10.1046/j.1365-3059.1997.d01-87.x
10.1007/978-1-4939-2438-7_1
10.21010/ajtcam.v13i6.20
10.1093/acprof:osobl/9780199549061.001.0001
10.1080/13102818.2017.1279572
10.1631/jzus.B0820154
10.1007/s13337-013-0188-2
10.1016/j.livsci.2010.01.021
10.21608/jhiph.2019.29464
10.1046/j.1439-0442.2001.00393.x
10.1625/jcam.8.37
10.1016/j.apjtm.2016.01.039
10.5053/ejobios.2010.4.0.2
10.3892/or.2012.2165
10.1016/j.intimp.2005.06.008
10.1055/s-0035-1557838
10.29261/pakvetj/2018.075
10.1002/(SICI)1521-3803(199810)42:05<290::AID-FOOD290>3.0.CO;2-Y
10.1086/590567
10.1016/S0944-7113(99)80046-4
10.3823/1993
10.1159/000197314
10.1371/journal.pntd.0003488
10.1155/2019/1528635
10.1016/B978-0-12-801238-3.02509-5
10.1016/S1473-3099(05)70270-X
10.3748/wjg.v19.i16.2529
10.21608/maj.2009.2667
10.5455/jice.20161018021238
10.1016/j.eplepsyres.2010.10.010
10.1186/1746-6148-10-24
10.1097/01.inf.0000188166.17324.60
10.17582/journal.pjz/2018.50.6.2223.2228
10.1016/0378-8741(87)90016-X
10.1155/2015/841823
10.4172/2157-7471.1000190
10.3923/pjbs.2007.4164.4167
10.1007/s11033-014-3019-7
10.1016/j.jcv.2004.02.009
10.4103/2225-4110.124335
10.1128/MMBR.69.4.635-664.2005
10.1016/j.drudis.2013.08.021
10.1177/1534735412458827
10.3382/japr/pfv070
10.1016/S0378-8741(02)00009-0
10.1186/1472-6882-11-29
10.1158/0008-5472.CAN-08-4235
10.4172/scientificreports.124
10.4314/ajtcam.v10i5.18
10.4314/tjhc.v18i1.64485
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References ref57
ref56
ref58
ref53
ref52
ref55
ref54
ref51
ref50
ref46
ref45
ref48
ref47
ref41
ref44
ref43
ref49
ref8
ref7
ref9
ref4
ref3
ref6
ref5
ref100
ref101
ref40
ref35
ref34
ref37
ref36
ref31
ref30
ref33
ref32
ref39
ref38
Aqil (ref13) 2018; 50
ref24
ref23
ref26
ref25
ref20
ref22
ref21
ref28
ref27
ref29
ref12
ref15
ref14
ref97
ref96
ref11
ref99
ref10
ref98
ref17
ref16
ref19
ref18
ref93
ref92
ref95
ref94
ref91
ref90
ref89
ref86
ref85
ref88
ref87
Houghton (ref42) 1995; 61
ref82
ref81
ref84
ref83
ref80
ref79
ref108
ref78
ref109
ref106
ref107
ref75
ref104
ref74
ref105
ref77
ref102
ref76
ref103
ref0
ref2
ref1
ref71
ref111
ref70
ref73
ref72
ref110
ref68
ref67
ref69
ref64
ref63
ref66
ref65
Mohamed (ref59) 2010; 16
ref60
ref62
ref61
References_xml – ident: ref38
  doi: 10.1089/acu.2016.1204
– ident: ref57
  doi: 10.5772/26946
– ident: ref85
– ident: ref34
  doi: 10.5897/AJMR11.009
– ident: ref39
  doi: 10.1038/nrgastro.2013.107
– ident: ref60
  doi: 10.1080/10942912.2017.1371189
– ident: ref9
  doi: 10.4103/pm.pm_108_18
– ident: ref10
  doi: 10.1007/s13318-014-0207-8
– ident: ref76
– ident: ref98
  doi: 10.3390/md10122795
– ident: ref78
  doi: 10.1016/S0192-0561(00)00036-9
– ident: ref81
  doi: 10.1111/j.1364-3703.2011.00752.x
– ident: ref82
  doi: 10.1084/jem.54.6.817
– ident: ref55
  doi: 10.1016/j.onehlt.2020.100123
– ident: ref53
– ident: ref100
  doi: 10.1016/j.bcp.2011.09.029
– ident: ref92
  doi: 10.1016/j.jssas.2016.09.004
– ident: ref30
– ident: ref35
  doi: 10.3390/v4113044
– ident: ref4
  doi: 10.1016/S2221-1691(13)60075-1
– ident: ref36
– ident: ref6
– ident: ref64
  doi: 10.1016/j.hermed.2013.04.006
– ident: ref107
– ident: ref47
  doi: 10.1080/01652176.2013.782119
– ident: ref63
  doi: 10.1016/bs.aivir.2016.08.001
– ident: ref62
  doi: 10.1016/j.jep.2015.09.022
– ident: ref43
  doi: 10.21475/ajcs.17.11.12.pne709
– ident: ref102
– ident: ref68
  doi: 10.4314/ajid.v9i2.6
– ident: ref52
  doi: 10.1371/journal.pone.0140765
– ident: ref37
  doi: 10.3389/fphar.2017.00656
– ident: ref12
– ident: ref23
  doi: 10.1016/S0140-6736(20)30211-7
– ident: ref3
– volume: 61
  start-page: 33
  issue: 6
  year: 1995
  ident: ref42
  article-title: Fixed oils of Nigella sativa and derived thymoquinone inhibit eicosaniod generation in leukocytes and membrane lipid peroxidation
  publication-title: Planta Med
  doi: 10.1055/s-2006-957994
  contributor:
    fullname: Houghton
– ident: ref58
– ident: ref83
– ident: ref108
– ident: ref109
  doi: 10.1016/S0378-8741(01)00342-7
– ident: ref71
  doi: 10.5501/wjv.v1.i5.142
– ident: ref41
– ident: ref74
  doi: 10.1142/S0192415X1100941X
– ident: ref40
  doi: 10.1002/ptr.1390
– ident: ref105
– ident: ref45
  doi: 10.3389/fcell.2020.00646
– ident: ref91
  doi: 10.3382/ps/pew069
– ident: ref50
  doi: 10.1017/S0043933917000848
– ident: ref20
  doi: 10.1177/1040638711407887
– ident: ref25
  doi: 10.1046/j.1365-3059.1997.d01-87.x
– ident: ref49
– ident: ref77
– ident: ref94
– ident: ref0
– ident: ref54
  doi: 10.1007/978-1-4939-2438-7_1
– ident: ref72
  doi: 10.21010/ajtcam.v13i6.20
– ident: ref111
  doi: 10.1093/acprof:osobl/9780199549061.001.0001
– ident: ref31
  doi: 10.1080/13102818.2017.1279572
– ident: ref97
  doi: 10.1631/jzus.B0820154
– ident: ref15
  doi: 10.1007/s13337-013-0188-2
– ident: ref86
  doi: 10.1016/j.livsci.2010.01.021
– ident: ref26
  doi: 10.21608/jhiph.2019.29464
– ident: ref56
  doi: 10.1046/j.1439-0442.2001.00393.x
– ident: ref67
  doi: 10.1625/jcam.8.37
– ident: ref103
– ident: ref2
  doi: 10.1016/j.apjtm.2016.01.039
– volume: 16
  start-page: 8
  issue: 4
  year: 2010
  ident: ref59
  article-title: The antibacterial, antiviral activities and phytochemical screening of some Sudanese medicinal plants
  publication-title: EurAsian Journal of BioSciences
  doi: 10.5053/ejobios.2010.4.0.2
  contributor:
    fullname: Mohamed
– ident: ref73
  doi: 10.3892/or.2012.2165
– ident: ref79
  doi: 10.1016/j.intimp.2005.06.008
– ident: ref11
  doi: 10.1055/s-0035-1557838
– ident: ref46
  doi: 10.29261/pakvetj/2018.075
– ident: ref8
  doi: 10.1002/(SICI)1521-3803(199810)42:05<290::AID-FOOD290>3.0.CO;2-Y
– ident: ref61
– ident: ref89
  doi: 10.1086/590567
– ident: ref18
  doi: 10.1016/S0944-7113(99)80046-4
– ident: ref88
  doi: 10.3823/1993
– ident: ref19
  doi: 10.1159/000197314
– ident: ref32
  doi: 10.1371/journal.pntd.0003488
– ident: ref106
  doi: 10.1155/2019/1528635
– ident: ref95
  doi: 10.1016/B978-0-12-801238-3.02509-5
– ident: ref29
  doi: 10.1016/S1473-3099(05)70270-X
– ident: ref17
  doi: 10.3748/wjg.v19.i16.2529
– ident: ref27
  doi: 10.21608/maj.2009.2667
– ident: ref75
  doi: 10.5455/jice.20161018021238
– ident: ref5
  doi: 10.1016/j.eplepsyres.2010.10.010
– ident: ref22
  doi: 10.1186/1746-6148-10-24
– ident: ref7
– ident: ref87
– ident: ref44
  doi: 10.1097/01.inf.0000188166.17324.60
– volume: 50
  start-page: 2223
  issue: 6
  year: 2018
  ident: ref13
  article-title: In vitro antiviral activity of Nigella sativa against Peste des petits ruminants (PPR) Virus
  publication-title: Zool Soc Pakistan
  doi: 10.17582/journal.pjz/2018.50.6.2223.2228
  contributor:
    fullname: Aqil
– ident: ref33
  doi: 10.1016/0378-8741(87)90016-X
– ident: ref48
  doi: 10.1155/2015/841823
– ident: ref101
– ident: ref1
  doi: 10.4172/2157-7471.1000190
– ident: ref28
  doi: 10.3923/pjbs.2007.4164.4167
– ident: ref70
– ident: ref90
  doi: 10.1007/s11033-014-3019-7
– ident: ref24
  doi: 10.1016/j.jcv.2004.02.009
– ident: ref51
  doi: 10.4103/2225-4110.124335
– ident: ref99
  doi: 10.1128/MMBR.69.4.635-664.2005
– ident: ref84
– ident: ref80
  doi: 10.1016/j.drudis.2013.08.021
– ident: ref110
  doi: 10.1177/1534735412458827
– ident: ref93
  doi: 10.3382/japr/pfv070
– ident: ref96
  doi: 10.1016/S0378-8741(02)00009-0
– ident: ref104
– ident: ref21
  doi: 10.1186/1472-6882-11-29
– ident: ref16
  doi: 10.1158/0008-5472.CAN-08-4235
– ident: ref66
  doi: 10.4172/scientificreports.124
– ident: ref69
  doi: 10.4314/ajtcam.v10i5.18
– ident: ref65
  doi: 10.4314/tjhc.v18i1.64485
– ident: ref14
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SubjectTerms antiviral activity
Antiviral agents
black seed
Medicinal plants
Medicine, Botanic
Medicine, Herbal
natural remedy
nigella sativa
Seeds
viruses
Title Nigella sativa (Black Seed) as a Natural Remedy against Viruses
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