Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements

• Published in: The American journal of clinical nutrition Vol. 76; no. 2; pp. 436 - 441
• Main Authors: McNulty, Helene, McKinley, Michelle C, Wilson, Barbara, McPartlin, Joseph, Strain, J.J, Weir, Donald G, Scott, John M
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Clinical Nutrition 01.08.2002; American Society for Clinical Nutrition, Inc
• Subjects: Adult; Analysis of Variance; Biological and medical sciences; cross-sectional studies; Diet; disease prevention; erythrocytes; Feeding. Feeding behavior; Female; folic acid; Folic Acid - blood; Fundamental and applied biological sciences. Psychology; Genotype; glutathione-disulfide reductase; homocysteine; Homocysteine - blood; homozygosity; Humans; in vitro studies; issues and policy; Male; Metabolism; methylenetetrahydrofolate reductase; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutrition; Nutritional Requirements; Nutritional Status; Oxidoreductases Acting on CH-NH Group Donors - genetics; Oxidoreductases Acting on CH-NH Group Donors - metabolism; Polymerase Chain Reaction; riboflavin; Riboflavin - blood; Riboflavin - physiology; risk; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vitamin B; Human; Temperature; Enzyme; Vitamin; Riboflavin; Environmental factor; ); Genotype; Metabolism; Genetic determinism; 5,10-Methylenetetrahydrofolate reductase (FADH; Feeding; Sensitivity resistance; Enzymatic activity; Homocystein; Oxidoreductases; Nutritional status

Background: Methylenetetrahydrofolate reductase (MTHFR; EC 1.7.99.5) supplies the folate needed for the metabolism of homocysteine. A reduction in MTHFR activity, as occurs in the homozygous state for the 677C to T (so-called thermolabile) enzyme variant (TT genotype), is associated with an increase...