STAT1 and STAT6 orchestrate Cbs transcription and transsulfur metabolism in microglia and contribute to parkinson’s disease-related neuroinflammation

• Published in: Cellular and molecular life sciences : CMLS Vol. 82; no. 1; pp. 294 - 20
• Main Authors: Liu, Yang, Wang, Zhen, Ma, Ya-Ting, Chen, Yu-Xuan, Qian, Xin-Yi, Hou, Xiao-Ou, Wan, Bo, Ren, Hai-Gang, Hu, Li-Fang
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 30.07.2025; Springer Nature B.V; Springer
• Subjects: Antibodies; Biochemistry; Biomedical and Life Sciences; Biomedicine; CBS; Cell Biology; Cystathionine b-synthase; DJ-1; Dopamine receptors; Fibrils; Gene regulation; Genetic factors; Homeostasis; Inflammation; Life Sciences; Lipopolysaccharides; Metabolism; Metabolites; Microglia; Movement disorders; Neurodegenerative diseases; Neurotoxicity; Nitric oxide; Original; Original Article; PARK7 protein; Parkinson's disease; Pathogenesis; Penicillin; Proteins; Signal transduction; STAT1; Stat1 protein; STAT6; Stat6 protein; Stimulation; Sulfur; Synuclein; Transcription activation; Transsulfur metabolism; Tumor necrosis factor-TNF; γ-Interferon; United States > US; Switzerland; China; Shanghai China; STAT6; DJ-1; CBS; STAT1; Transsulfur metabolism; Microglia

Microglia-mediated neuroinflammation is implicated in the pathogenesis of Parkinson’s disease (PD). Cystathionine β-synthase (CBS) and transsulfur metabolism modulate neuroinflammation. However, the regulation of Cbs transcription is poorly understood, and it remains unknown whether microglial CBS e...