Alternative Splicing at N Terminus and Domain I Modulates CaV1.2 Inactivation and Surface Expression

• Published in: Biophysical journal Vol. 114; no. 9; pp. 2095 - 2106
• Main Authors: Bartels, Peter, Yu, Dejie, Huang, Hua, Hu, Zhenyu, Herzig, Stefan, Soong, Tuck Wah
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 08.05.2018; The Biophysical Society
• Subjects: Channels and Transporters

The CaV1.2 L-type calcium channel is a key conduit for Ca2+ influx to initiate excitation-contraction coupling for contraction of the heart and vasoconstriction of the arteries and for altering membrane excitability in neurons. Its α1C pore-forming subunit is known to undergo extensive alternative s...