Involvement of tumor necrosis factor-alpha in development of hepatic injury in galactosamine-sensitized mice

• Published in: Hepatology (Baltimore, Md.) Vol. 12; no. 5; p. 1187
• Main Authors: Hishinuma, I, Nagakawa, J, Hirota, K, Miyamoto, K, Tsukidate, K, Yamanaka, T, Katayama, K, Yamatsu, I
• Format: Journal Article
• Language: English
• Published: United States 01.11.1990
• Subjects: Alanine Transaminase - blood; Animals; Aspartate Aminotransferases - blood; Galactosamine - pharmacology; Immune Sera - immunology; Immunization, Passive; Lipopolysaccharides - pharmacology; Liver - drug effects; Liver - pathology; Mice; Mice, Inbred C3H; Tumor Necrosis Factor-alpha - immunology; Tumor Necrosis Factor-alpha - pharmacology

Intravenous injection of lipopolysaccharide and D-galactosamine, at doses of 0.2 micrograms/kg and 800 mg/kg, respectively, elicited massive hepatic necrosis within 24 hr in C3H/HeN mice. The plasma L-alanine aminotransferase (ALT, E.C. 2.6.1.2) or L-aspartate aminotransferase (AST, E.C. 2.6.1.1) ac...