Integrative proteogenomic characterization of Wilms tumor

• Published in: Nature communications Vol. 16; no. 1; pp. 7715 - 20
• Main Authors: Cheng, Cheng, Zhang, Li, Chang, Xiaofeng, Chen, Kai, He, Tian, Shi, Jia, Lv, Fan, Pan, Lijia, Wu, Yangkun, Cheng, Qianqian, Ren, Dong, Guo, Yongli, Zhang, Weiping, Wang, Huanmin, Shi, Tieliu, Li, Jing, Ni, Xin, Wu, Yeming, Jin, Yaqiong, Wu, Zhixiang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.08.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 38/91; 45/23; 631/67/2329; 631/67/2332; 631/67/589/1588/1683; 631/67/69; 82/58; Biomarkers; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Child; Developmental stages; Embryogenesis; Epigenesis, Genetic; Epigenetics; Exome Sequencing; Female; Gene Expression Regulation, Neoplastic; Genes; Genomics; Humanities and Social Sciences; Humans; Kidney - metabolism; Kidney - pathology; Kidney Neoplasms - genetics; Kidney Neoplasms - metabolism; Kidney Neoplasms - pathology; Kidneys; Male; Malignancy; Mann-Whitney U test; Medical prognosis; Metastasis; Microenvironments; multidisciplinary; Mutation; Pathogenesis; Pediatrics; Phosphorylation; Prognosis; Protein expression; Proteins; Proteogenomics - methods; Proteome - genetics; Proteomes; Proteomics; Proteomics - methods; Science; Science (multidisciplinary); Subgroups; Therapeutic targets; Transcriptome; Transcriptomes; Transcriptomics; Tumor Microenvironment; Tumorigenesis; Tumors; Whole genome sequencing; Wilms Tumor - genetics; Wilms Tumor - metabolism; Wilms Tumor - pathology; Wnt protein; Wnt Signaling Pathway - genetics; β-Catenin

Wilms tumor (WT), the most common pediatric renal malignancy, exhibits a relatively low mutational burden compared to adult cancers, which hinders the development of targeted therapies. To elucidate the molecular landscape of WT, we perform integrative proteomic, phosphoproteomic, transcriptomic, an...