Integrative proteogenomic characterization of Wilms tumor

Wilms tumor (WT), the most common pediatric renal malignancy, exhibits a relatively low mutational burden compared to adult cancers, which hinders the development of targeted therapies. To elucidate the molecular landscape of WT, we perform integrative proteomic, phosphoproteomic, transcriptomic, an...

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Published inNature communications Vol. 16; no. 1; pp. 7715 - 20
Main Authors Cheng, Cheng, Zhang, Li, Chang, Xiaofeng, Chen, Kai, He, Tian, Shi, Jia, Lv, Fan, Pan, Lijia, Wu, Yangkun, Cheng, Qianqian, Ren, Dong, Guo, Yongli, Zhang, Weiping, Wang, Huanmin, Shi, Tieliu, Li, Jing, Ni, Xin, Wu, Yeming, Jin, Yaqiong, Wu, Zhixiang
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 19.08.2025
Nature Publishing Group
Nature Portfolio
Subjects
38/91
45/23
631/67/2329
631/67/2332
631/67/589/1588/1683
631/67/69
82/58
Biomarkers
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Child
Developmental stages
Embryogenesis
Epigenesis, Genetic
Epigenetics
Exome Sequencing
Female
Gene Expression Regulation, Neoplastic
Genes
Genomics
Humanities and Social Sciences
Humans
Kidney - metabolism
Kidney - pathology
Kidney Neoplasms - genetics
Kidney Neoplasms - metabolism
Kidney Neoplasms - pathology
Kidneys
Male
Malignancy
Mann-Whitney U test
Medical prognosis
Metastasis
Microenvironments
multidisciplinary
Mutation
Pathogenesis
Pediatrics
Phosphorylation
Prognosis
Protein expression
Proteins
Proteogenomics - methods
Proteome - genetics
Proteomes
Proteomics
Proteomics - methods
Science
Science (multidisciplinary)
Subgroups
Therapeutic targets
Transcriptome
Transcriptomes
Transcriptomics
Tumor Microenvironment
Tumorigenesis
Tumors
Whole genome sequencing
Wilms Tumor - genetics
Wilms Tumor - metabolism
Wilms Tumor - pathology
Wnt protein
Wnt Signaling Pathway - genetics
β-Catenin
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Abstract Wilms tumor (WT), the most common pediatric renal malignancy, exhibits a relatively low mutational burden compared to adult cancers, which hinders the development of targeted therapies. To elucidate the molecular landscape of WT, we perform integrative proteomic, phosphoproteomic, transcriptomic, and whole-exome sequencing analyses of WT and normal kidney tissue adjacent to tumor. Our multi-omics approach uncovers prognostic genetic alterations, distinct molecular subgroups, immune microenvironment features, and potential biomarkers and therapeutic targets. Proteome- and transcriptome-based stratification identifies three molecular subgroups with unique signatures, correlating with different histopathological subtypes and putative cellular origins at different stages of embryonic kidney development. Notably, we identify EHMT2 as a promising prognostic biomarker and therapeutic target associated with epigenetic regulation and Wnt/β-catenin pathway. In this work, we provide a comprehensive molecular characterization of WT, offering valuable insights into its pathogenesis and a foundational resource for future therapeutic development. Wilms tumours are the most common malignant kidney tumour type in children, and their low mutational burden has impeded the development of targeted therapies. Here, the authors perform a proteogenomic characterisation of Wilms tumours, revealing molecular subtypes with different clinical features and identifying EHMT2 as a potential prognostic marker and therapeutic target.
AbstractList Wilms tumor (WT), the most common pediatric renal malignancy, exhibits a relatively low mutational burden compared to adult cancers, which hinders the development of targeted therapies. To elucidate the molecular landscape of WT, we perform integrative proteomic, phosphoproteomic, transcriptomic, and whole-exome sequencing analyses of WT and normal kidney tissue adjacent to tumor. Our multi-omics approach uncovers prognostic genetic alterations, distinct molecular subgroups, immune microenvironment features, and potential biomarkers and therapeutic targets. Proteome- and transcriptome-based stratification identifies three molecular subgroups with unique signatures, correlating with different histopathological subtypes and putative cellular origins at different stages of embryonic kidney development. Notably, we identify EHMT2 as a promising prognostic biomarker and therapeutic target associated with epigenetic regulation and Wnt/β-catenin pathway. In this work, we provide a comprehensive molecular characterization of WT, offering valuable insights into its pathogenesis and a foundational resource for future therapeutic development. Wilms tumours are the most common malignant kidney tumour type in children, and their low mutational burden has impeded the development of targeted therapies. Here, the authors perform a proteogenomic characterisation of Wilms tumours, revealing molecular subtypes with different clinical features and identifying EHMT2 as a potential prognostic marker and therapeutic target.
Wilms tumor (WT), the most common pediatric renal malignancy, exhibits a relatively low mutational burden compared to adult cancers, which hinders the development of targeted therapies. To elucidate the molecular landscape of WT, we perform integrative proteomic, phosphoproteomic, transcriptomic, and whole-exome sequencing analyses of WT and normal kidney tissue adjacent to tumor. Our multi-omics approach uncovers prognostic genetic alterations, distinct molecular subgroups, immune microenvironment features, and potential biomarkers and therapeutic targets. Proteome- and transcriptome-based stratification identifies three molecular subgroups with unique signatures, correlating with different histopathological subtypes and putative cellular origins at different stages of embryonic kidney development. Notably, we identify EHMT2 as a promising prognostic biomarker and therapeutic target associated with epigenetic regulation and Wnt/β-catenin pathway. In this work, we provide a comprehensive molecular characterization of WT, offering valuable insights into its pathogenesis and a foundational resource for future therapeutic development.Wilms tumor (WT), the most common pediatric renal malignancy, exhibits a relatively low mutational burden compared to adult cancers, which hinders the development of targeted therapies. To elucidate the molecular landscape of WT, we perform integrative proteomic, phosphoproteomic, transcriptomic, and whole-exome sequencing analyses of WT and normal kidney tissue adjacent to tumor. Our multi-omics approach uncovers prognostic genetic alterations, distinct molecular subgroups, immune microenvironment features, and potential biomarkers and therapeutic targets. Proteome- and transcriptome-based stratification identifies three molecular subgroups with unique signatures, correlating with different histopathological subtypes and putative cellular origins at different stages of embryonic kidney development. Notably, we identify EHMT2 as a promising prognostic biomarker and therapeutic target associated with epigenetic regulation and Wnt/β-catenin pathway. In this work, we provide a comprehensive molecular characterization of WT, offering valuable insights into its pathogenesis and a foundational resource for future therapeutic development.
Wilms tumor (WT), the most common pediatric renal malignancy, exhibits a relatively low mutational burden compared to adult cancers, which hinders the development of targeted therapies. To elucidate the molecular landscape of WT, we perform integrative proteomic, phosphoproteomic, transcriptomic, and whole-exome sequencing analyses of WT and normal kidney tissue adjacent to tumor. Our multi-omics approach uncovers prognostic genetic alterations, distinct molecular subgroups, immune microenvironment features, and potential biomarkers and therapeutic targets. Proteome- and transcriptome-based stratification identifies three molecular subgroups with unique signatures, correlating with different histopathological subtypes and putative cellular origins at different stages of embryonic kidney development. Notably, we identify EHMT2 as a promising prognostic biomarker and therapeutic target associated with epigenetic regulation and Wnt/β-catenin pathway. In this work, we provide a comprehensive molecular characterization of WT, offering valuable insights into its pathogenesis and a foundational resource for future therapeutic development.
Abstract Wilms tumor (WT), the most common pediatric renal malignancy, exhibits a relatively low mutational burden compared to adult cancers, which hinders the development of targeted therapies. To elucidate the molecular landscape of WT, we perform integrative proteomic, phosphoproteomic, transcriptomic, and whole-exome sequencing analyses of WT and normal kidney tissue adjacent to tumor. Our multi-omics approach uncovers prognostic genetic alterations, distinct molecular subgroups, immune microenvironment features, and potential biomarkers and therapeutic targets. Proteome- and transcriptome-based stratification identifies three molecular subgroups with unique signatures, correlating with different histopathological subtypes and putative cellular origins at different stages of embryonic kidney development. Notably, we identify EHMT2 as a promising prognostic biomarker and therapeutic target associated with epigenetic regulation and Wnt/β-catenin pathway. In this work, we provide a comprehensive molecular characterization of WT, offering valuable insights into its pathogenesis and a foundational resource for future therapeutic development.
Wilms tumor (WT), the most common pediatric renal malignancy, exhibits a relatively low mutational burden compared to adult cancers, which hinders the development of targeted therapies. To elucidate the molecular landscape of WT, we perform integrative proteomic, phosphoproteomic, transcriptomic, and whole-exome sequencing analyses of WT and normal kidney tissue adjacent to tumor. Our multi-omics approach uncovers prognostic genetic alterations, distinct molecular subgroups, immune microenvironment features, and potential biomarkers and therapeutic targets. Proteome- and transcriptome-based stratification identifies three molecular subgroups with unique signatures, correlating with different histopathological subtypes and putative cellular origins at different stages of embryonic kidney development. Notably, we identify EHMT2 as a promising prognostic biomarker and therapeutic target associated with epigenetic regulation and Wnt/β-catenin pathway. In this work, we provide a comprehensive molecular characterization of WT, offering valuable insights into its pathogenesis and a foundational resource for future therapeutic development.Wilms tumours are the most common malignant kidney tumour type in children, and their low mutational burden has impeded the development of targeted therapies. Here, the authors perform a proteogenomic characterisation of Wilms tumours, revealing molecular subtypes with different clinical features and identifying EHMT2 as a potential prognostic marker and therapeutic target.
ArticleNumber 7715
Author Ni, Xin
Cheng, Qianqian
Wang, Huanmin
Cheng, Cheng
Lv, Fan
Pan, Lijia
Shi, Tieliu
Zhang, Li
Shi, Jia
Li, Jing
Wu, Yeming
Wu, Yangkun
Guo, Yongli
Chen, Kai
Chang, Xiaofeng
He, Tian
Ren, Dong
Zhang, Weiping
Jin, Yaqiong
Wu, Zhixiang
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  organization: Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Division of Pediatric Oncology, Shanghai Institute of Pediatric Research
BackLink https://www.ncbi.nlm.nih.gov/pubmed/40830093$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.ccell.2021.01.006
10.1200/JCO.18.01972
10.1093/nar/gkaa1087
10.1074/mcp.M116.065524
10.1111/cas.12910
10.1038/nature25480
10.3410/f.726559766.793531702
10.1016/j.cell.2018.04.008
10.1093/bioinformatics/btp352
10.1038/nbt.3122
10.1038/nrclinonc.2017.166
10.1038/ng0506-500
10.1016/j.gpb.2021.08.001
10.1016/j.cell.2019.03.030
10.3390/genes12020318
10.1002/mpo.2950210305
10.1093/nar/gkac883
10.1038/nmeth.3317
10.1073/pnas.0506580102
10.1038/s41572-021-00308-8
10.1158/1078-0432.CCR-16-0985
10.1007/s00018-015-2070-4
10.1101/gr.239244.118
10.1016/j.cell.2015.09.053
10.1038/ncomms3612
10.1016/j.mcpro.2023.100504
10.1111/febs.16334
10.1093/nar/gky869
10.1016/j.cell.2019.12.026
10.1093/nar/gkab1081
10.1152/physrev.1999.79.4.1157
10.1093/nar/gkad1078
10.1097/SLA.0000000000001716
10.1038/s41581-019-0112-0
10.1038/s41596-018-0014-9
10.3390/cells12040530
10.1016/S1470-2045(18)30438-8
10.1158/2159-8290.CD-13-0219
10.3389/fphar.2019.00203
10.1200/JCO.2015.66.1140
10.1186/gb-2011-12-4-r41
10.1158/0008-5472.CAN-05-4528
10.1016/j.cels.2015.12.004
10.1186/1471-2105-14-7
10.1016/j.celrep.2021.110047
10.1093/bioinformatics/btr260
10.1080/2162402X.2018.1542245
10.1038/nbt.3172
10.1038/nrc3002
10.1038/s41587-019-0114-2
10.1016/j.ccell.2022.12.001
10.1136/jitc-2022-004797
10.5281/zenodo.15542663
10.1007/s11033-010-0149-4
10.1016/j.phrs.2019.104511
10.1159/000101298
10.1016/j.celrep.2018.08.056
10.1158/2159-8290.CD-19-0532
10.1126/science.aat1699
10.1002/wdev.338
10.1093/nar/gkr1122
10.1681/ASN.2017040391
10.1093/bioinformatics/bts034
10.1038/sj.bjc.6601894
10.1016/j.cels.2017.05.009
10.1634/stemcells.2007-0322
10.1038/nrneph.2016.54
10.1016/j.ebiom.2016.05.029
10.1002/ijc.33147
10.1016/j.bbcan.2020.188498
10.1016/S0140-6736(22)01541-0
10.1200/JCO.2005.01.2799
10.1093/nar/gkv007
10.3390/genes12060800
10.1093/bioinformatics/btx378
10.1038/ng.3940
10.1007/s10549-015-3435-y
10.1186/s13578-021-00663-9
10.1093/bioinformatics/btp324
10.3390/cancers12030729
10.1002/pbc.30130
10.1101/gr.129684.111
10.1371/journal.pone.0015543
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References EJ Gratias (62234_CR12) 2016; 34
MJ Ellis (62234_CR22) 2013; 3
SS Li (62234_CR29) 2021; 12
N Breslow (62234_CR1) 1993; 21
DB Bekker-Jensen (62234_CR16) 2017; 4
H Li (62234_CR72) 2009; 25
Q Zhang (62234_CR20) 2010; 38
B Dekel (62234_CR35) 2006; 66
S Bamford (62234_CR28) 2004; 91
ME Ritchie (62234_CR84) 2015; 43
VG Kaklamani (62234_CR64) 2015; 151
AS Brohl (62234_CR46) 2021; 37
62234_CR27
Z Li (62234_CR53) 2016; 73
L Xia (62234_CR55) 2021; 20
62234_CR62
Z Zhang (62234_CR75) 2015; 11
SN Grobner (62234_CR10) 2018; 555
DC Koboldt (62234_CR70) 2012; 22
62234_CR63
J Ma (62234_CR92) 2019; 47
DB Dix (62234_CR11) 2019; 37
A Mayakonda (62234_CR74) 2018; 28
CH Mermel (62234_CR76) 2011; 12
Y Feng (62234_CR30) 2018; 29
S Vasaikar (62234_CR48) 2019; 177
MV Ortiz (62234_CR19) 2019; 4
Z Miao (62234_CR42) 2021; 12
A Frankish (62234_CR79) 2021; 49
CL Chaffer (62234_CR40) 2007; 185
62234_CR36
C Cheng (62234_CR95) 2025
S Metsuyanim (62234_CR34) 2008; 26
AM Newman (62234_CR45) 2019; 37
JT Leek (62234_CR83) 2012; 28
AC Frazee (62234_CR81) 2015; 33
S Kato (62234_CR50) 2020; 10
62234_CR32
T Chen (62234_CR93) 2021; 19
MD Young (62234_CR37) 2018; 361
PV Hornbeck (62234_CR26) 2012; 40
GD Cresswell (62234_CR60) 2016; 9
R Boldrini (62234_CR47) 2019; 8
T Xu (62234_CR85) 2017; 33
A Liberzon (62234_CR44) 2015; 1
PE Grundy (62234_CR51) 2005; 23
K Nakata (62234_CR2) 2020; 147
DJ Clark (62234_CR18) 2020; 180
Y Hoshida (62234_CR33) 2010; 5
SJ Humphrey (62234_CR69) 2018; 13
AHAG Ooms (62234_CR5) 2016; 22
C Deng (62234_CR6) 2016; 107
M Pertea (62234_CR80) 2015; 33
Y Guo (62234_CR49) 2021; 11
62234_CR4
H Rodriguez (62234_CR14) 2018; 173
M Reich (62234_CR77) 2006; 38
K Yoshihara (62234_CR88) 2013; 4
Y Li (62234_CR24) 2023; 41
K Wang (62234_CR73) 2010; 38
X Ni (62234_CR3) 2022; 400
A Subramanian (62234_CR43) 2005; 102
MS Tham (62234_CR41) 2019; 8
Members, C.-N. & Partners (62234_CR94) 2024; 52
Y Tan (62234_CR54) 2022; 13
I Dagogo-Jack (62234_CR15) 2018; 15
AF Abdel-Wahab (62234_CR56) 2019; 150
A Nachiyappan (62234_CR67) 2022; 289
H Li (62234_CR71) 2009; 25
LB Wang (62234_CR23) 2021; 39
M Edeling (62234_CR31) 2016; 12
CV Fernandez (62234_CR52) 2017; 265
MF Horster (62234_CR39) 1999; 79
D Kim (62234_CR78) 2015; 12
N Saha (62234_CR68) 2021; 1875
A Liberzon (62234_CR89) 2011; 27
C Cheng (62234_CR90) 2023; 22
P Jagust (62234_CR57) 2019; 10
J Zhang (62234_CR21) 2019; 676
B Sen (62234_CR65) 2012; 4
T Chen (62234_CR91) 2022; 50
MY Hein (62234_CR17) 2015; 163
TD Treger (62234_CR9) 2019; 15
62234_CR58
G Grignani (62234_CR66) 2018; 19
62234_CR59
62234_CR13
T Wu (62234_CR86) 2021; 2
DL Plubell (62234_CR82) 2017; 16
V Huff (62234_CR8) 2011; 11
P Lo Surdo (62234_CR25) 2023; 51
MD Young (62234_CR38) 2021; 12
S Gadd (62234_CR7) 2017; 49
P Wang (62234_CR61) 2018; 24
S Hanzelmann (62234_CR87) 2013; 14
References_xml – volume: 39
  start-page: 509
  year: 2021
  ident: 62234_CR23
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2021.01.006
– volume: 37
  start-page: 2769
  year: 2019
  ident: 62234_CR11
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.18.01972
– volume: 49
  start-page: D916
  year: 2021
  ident: 62234_CR79
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa1087
– volume: 16
  start-page: 873
  year: 2017
  ident: 62234_CR82
  publication-title: Mol. Cell Proteom.
  doi: 10.1074/mcp.M116.065524
– volume: 107
  start-page: 690
  year: 2016
  ident: 62234_CR6
  publication-title: Cancer Sci.
  doi: 10.1111/cas.12910
– volume: 555
  start-page: 321
  year: 2018
  ident: 62234_CR10
  publication-title: Nature
  doi: 10.1038/nature25480
– ident: 62234_CR13
  doi: 10.3410/f.726559766.793531702
– volume: 173
  start-page: 535
  year: 2018
  ident: 62234_CR14
  publication-title: Cell
  doi: 10.1016/j.cell.2018.04.008
– volume: 25
  start-page: 2078
  year: 2009
  ident: 62234_CR72
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp352
– volume: 33
  start-page: 290
  year: 2015
  ident: 62234_CR80
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3122
– volume: 15
  start-page: 81
  year: 2018
  ident: 62234_CR15
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/nrclinonc.2017.166
– volume: 38
  start-page: 500
  year: 2006
  ident: 62234_CR77
  publication-title: Nat. Genet
  doi: 10.1038/ng0506-500
– volume: 2
  year: 2021
  ident: 62234_CR86
  publication-title: Innovation
– volume: 19
  start-page: 578
  year: 2021
  ident: 62234_CR93
  publication-title: Genomics Proteom. Bioinforma.
  doi: 10.1016/j.gpb.2021.08.001
– volume: 177
  start-page: 1035
  year: 2019
  ident: 62234_CR48
  publication-title: Cell
  doi: 10.1016/j.cell.2019.03.030
– ident: 62234_CR36
  doi: 10.3390/genes12020318
– volume: 21
  start-page: 172
  year: 1993
  ident: 62234_CR1
  publication-title: Med. Pediatr. Oncol.
  doi: 10.1002/mpo.2950210305
– volume: 51
  start-page: D631
  year: 2023
  ident: 62234_CR25
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkac883
– volume: 12
  start-page: 357
  year: 2015
  ident: 62234_CR78
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3317
– volume: 102
  start-page: 15545
  year: 2005
  ident: 62234_CR43
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0506580102
– ident: 62234_CR59
  doi: 10.1038/s41572-021-00308-8
– volume: 22
  start-page: 5582
  year: 2016
  ident: 62234_CR5
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-16-0985
– volume: 73
  start-page: 377
  year: 2016
  ident: 62234_CR53
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-015-2070-4
– volume: 28
  start-page: 1747
  year: 2018
  ident: 62234_CR74
  publication-title: Genome Res
  doi: 10.1101/gr.239244.118
– volume: 163
  start-page: 712
  year: 2015
  ident: 62234_CR17
  publication-title: Cell
  doi: 10.1016/j.cell.2015.09.053
– volume: 4
  year: 2013
  ident: 62234_CR88
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms3612
– volume: 22
  year: 2023
  ident: 62234_CR90
  publication-title: Mol. Cell Proteom.
  doi: 10.1016/j.mcpro.2023.100504
– volume: 289
  start-page: 1329
  year: 2022
  ident: 62234_CR67
  publication-title: FEBS J.
  doi: 10.1111/febs.16334
– volume: 47
  start-page: D1211
  year: 2019
  ident: 62234_CR92
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky869
– volume: 180
  start-page: 207
  year: 2020
  ident: 62234_CR18
  publication-title: Cell
  doi: 10.1016/j.cell.2019.12.026
– volume: 50
  start-page: D1522
  year: 2022
  ident: 62234_CR91
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkab1081
– volume: 79
  start-page: 1157
  year: 1999
  ident: 62234_CR39
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.1999.79.4.1157
– volume: 52
  start-page: D18
  year: 2024
  ident: 62234_CR94
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkad1078
– volume: 265
  start-page: 835
  year: 2017
  ident: 62234_CR52
  publication-title: Ann. Surg.
  doi: 10.1097/SLA.0000000000001716
– volume: 15
  start-page: 240
  year: 2019
  ident: 62234_CR9
  publication-title: Nat. Rev. Nephrol.
  doi: 10.1038/s41581-019-0112-0
– volume: 13
  start-page: 1897
  year: 2018
  ident: 62234_CR69
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-018-0014-9
– ident: 62234_CR63
  doi: 10.3390/cells12040530
– volume: 19
  start-page: 1360
  year: 2018
  ident: 62234_CR66
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(18)30438-8
– volume: 3
  start-page: 1108
  year: 2013
  ident: 62234_CR22
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-13-0219
– volume: 10
  start-page: 203
  year: 2019
  ident: 62234_CR57
  publication-title: Front. Pharm.
  doi: 10.3389/fphar.2019.00203
– volume: 34
  start-page: 3189
  year: 2016
  ident: 62234_CR12
  publication-title: J. Clin. Oncol. J. Am. Soc. Clin. Oncol.
  doi: 10.1200/JCO.2015.66.1140
– volume: 12
  year: 2011
  ident: 62234_CR76
  publication-title: Genome Biol.
  doi: 10.1186/gb-2011-12-4-r41
– volume: 66
  start-page: 6040
  year: 2006
  ident: 62234_CR35
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-05-4528
– volume: 1
  start-page: 417
  year: 2015
  ident: 62234_CR44
  publication-title: Cell Syst.
  doi: 10.1016/j.cels.2015.12.004
– volume: 20
  year: 2021
  ident: 62234_CR55
  publication-title: Mol. Cancer
– volume: 14
  year: 2013
  ident: 62234_CR87
  publication-title: BMC Bioinforma.
  doi: 10.1186/1471-2105-14-7
– volume: 37
  year: 2021
  ident: 62234_CR46
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.110047
– volume: 676
  year: 2019
  ident: 62234_CR21
  publication-title: Arch. Biochem. Biophys.
– volume: 27
  start-page: 1739
  year: 2011
  ident: 62234_CR89
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr260
– volume: 8
  start-page: e1542245
  year: 2019
  ident: 62234_CR47
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2018.1542245
– volume: 11
  year: 2015
  ident: 62234_CR75
  publication-title: PLoS Comput. Biol.
– volume: 33
  start-page: 243
  year: 2015
  ident: 62234_CR81
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3172
– volume: 11
  start-page: 111
  year: 2011
  ident: 62234_CR8
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3002
– volume: 37
  start-page: 773
  year: 2019
  ident: 62234_CR45
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-019-0114-2
– volume: 41
  start-page: 139
  year: 2023
  ident: 62234_CR24
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2022.12.001
– ident: 62234_CR62
  doi: 10.1136/jitc-2022-004797
– volume: 38
  year: 2010
  ident: 62234_CR73
  publication-title: Nucleic Acids Res
– year: 2025
  ident: 62234_CR95
  publication-title: Zenodo
  doi: 10.5281/zenodo.15542663
– volume: 38
  start-page: 631
  year: 2010
  ident: 62234_CR20
  publication-title: Mol. Biol. Rep.
  doi: 10.1007/s11033-010-0149-4
– volume: 150
  start-page: 104511
  year: 2019
  ident: 62234_CR56
  publication-title: Pharm. Res.
  doi: 10.1016/j.phrs.2019.104511
– volume: 4
  year: 2019
  ident: 62234_CR19
  publication-title: JCI Insight
– volume: 185
  start-page: 7
  year: 2007
  ident: 62234_CR40
  publication-title: Cells Tissues Organs
  doi: 10.1159/000101298
– volume: 24
  start-page: 3554
  year: 2018
  ident: 62234_CR61
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.08.056
– volume: 10
  start-page: 980
  year: 2020
  ident: 62234_CR50
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-19-0532
– volume: 4
  start-page: 136ra170
  year: 2012
  ident: 62234_CR65
  publication-title: Sci. Transl. Med.
– volume: 12
  year: 2021
  ident: 62234_CR38
  publication-title: Nat. Commun.
– volume: 361
  start-page: 594
  year: 2018
  ident: 62234_CR37
  publication-title: Science
  doi: 10.1126/science.aat1699
– volume: 8
  start-page: e338
  year: 2019
  ident: 62234_CR41
  publication-title: Wiley Interdiscip. Rev. Dev. Biol.
  doi: 10.1002/wdev.338
– ident: 62234_CR4
– volume: 40
  start-page: D261
  year: 2012
  ident: 62234_CR26
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkr1122
– volume: 29
  start-page: 182
  year: 2018
  ident: 62234_CR30
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2017040391
– volume: 28
  start-page: 882
  year: 2012
  ident: 62234_CR83
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts034
– volume: 91
  start-page: 355
  year: 2004
  ident: 62234_CR28
  publication-title: Br. J. Cancer
  doi: 10.1038/sj.bjc.6601894
– volume: 4
  start-page: 587
  year: 2017
  ident: 62234_CR16
  publication-title: Cell Syst.
  doi: 10.1016/j.cels.2017.05.009
– volume: 26
  start-page: 1808
  year: 2008
  ident: 62234_CR34
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2007-0322
– volume: 12
  year: 2021
  ident: 62234_CR29
  publication-title: Front. Pharm.
– volume: 12
  start-page: 426
  year: 2016
  ident: 62234_CR31
  publication-title: Nat. Rev. Nephrol.
  doi: 10.1038/nrneph.2016.54
– volume: 9
  start-page: 120
  year: 2016
  ident: 62234_CR60
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2016.05.029
– volume: 13
  year: 2022
  ident: 62234_CR54
  publication-title: Nat. Commun.
– volume: 12
  year: 2021
  ident: 62234_CR42
  publication-title: Nat. Commun.
– volume: 147
  start-page: 3313
  year: 2020
  ident: 62234_CR2
  publication-title: Int J. Cancer
  doi: 10.1002/ijc.33147
– volume: 1875
  start-page: 188498
  year: 2021
  ident: 62234_CR68
  publication-title: Biochim Biophys. Acta Rev. Cancer
  doi: 10.1016/j.bbcan.2020.188498
– volume: 400
  start-page: 1020
  year: 2022
  ident: 62234_CR3
  publication-title: Lancet
  doi: 10.1016/S0140-6736(22)01541-0
– volume: 23
  start-page: 7312
  year: 2005
  ident: 62234_CR51
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2005.01.2799
– volume: 43
  start-page: e47
  year: 2015
  ident: 62234_CR84
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv007
– ident: 62234_CR32
  doi: 10.3390/genes12060800
– volume: 33
  start-page: 3131
  year: 2017
  ident: 62234_CR85
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btx378
– volume: 49
  start-page: 1487
  year: 2017
  ident: 62234_CR7
  publication-title: Nat. Genet
  doi: 10.1038/ng.3940
– volume: 151
  start-page: 629
  year: 2015
  ident: 62234_CR64
  publication-title: Breast Cancer Res. Treat.
  doi: 10.1007/s10549-015-3435-y
– volume: 11
  start-page: 152
  year: 2021
  ident: 62234_CR49
  publication-title: Cell Biosci.
  doi: 10.1186/s13578-021-00663-9
– volume: 25
  start-page: 1754
  year: 2009
  ident: 62234_CR71
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp324
– ident: 62234_CR27
  doi: 10.3390/cancers12030729
– ident: 62234_CR58
  doi: 10.1002/pbc.30130
– volume: 22
  start-page: 568
  year: 2012
  ident: 62234_CR70
  publication-title: Genome Res.
  doi: 10.1101/gr.129684.111
– volume: 5
  start-page: e15543
  year: 2010
  ident: 62234_CR33
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0015543
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Snippet Wilms tumor (WT), the most common pediatric renal malignancy, exhibits a relatively low mutational burden compared to adult cancers, which hinders the...
Abstract Wilms tumor (WT), the most common pediatric renal malignancy, exhibits a relatively low mutational burden compared to adult cancers, which hinders the...
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SubjectTerms 38/91
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Biomarkers
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Child
Developmental stages
Embryogenesis
Epigenesis, Genetic
Epigenetics
Exome Sequencing
Female
Gene Expression Regulation, Neoplastic
Genes
Genomics
Humanities and Social Sciences
Humans
Kidney - metabolism
Kidney - pathology
Kidney Neoplasms - genetics
Kidney Neoplasms - metabolism
Kidney Neoplasms - pathology
Kidneys
Male
Malignancy
Mann-Whitney U test
Medical prognosis
Metastasis
Microenvironments
multidisciplinary
Mutation
Pathogenesis
Pediatrics
Phosphorylation
Prognosis
Protein expression
Proteins
Proteogenomics - methods
Proteome - genetics
Proteomes
Proteomics
Proteomics - methods
Science
Science (multidisciplinary)
Subgroups
Therapeutic targets
Transcriptome
Transcriptomes
Transcriptomics
Tumor Microenvironment
Tumorigenesis
Tumors
Whole genome sequencing
Wilms Tumor - genetics
Wilms Tumor - metabolism
Wilms Tumor - pathology
Wnt protein
Wnt Signaling Pathway - genetics
β-Catenin
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Title Integrative proteogenomic characterization of Wilms tumor
URI https://link.springer.com/article/10.1038/s41467-025-62234-7
https://www.ncbi.nlm.nih.gov/pubmed/40830093
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Volume 16
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