Proteome of oocyte spindle identifies Ccdc69 regulates spindle assembly like “band-tightening spell”

• Published in: Cellular and molecular life sciences : CMLS Vol. 82; no. 1; pp. 292 - 20
• Main Authors: Guo, Jia-Ni, Zhu, Liu, Meng, Tie-Gang, Zhang, Yi-Na, Sun, Si-Min, Yang, Xue-Mei, Zhao, Bing-Wang, Lu, Yi-Ke, Xu, Yuan-Hong, Yue, Wei, Han, Zhiming, Wong, Catherine C. L., Wang, Zhen-Bo
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 30.07.2025; Springer Nature B.V; Springer
• Subjects: Animals; Biochemistry; Biomedical and Life Sciences; Biomedicine; Ccdc69; Cell Biology; Cell cycle; Cell division; Chromosomes; Female; Females; Fertility; Gametocytes; Kinases; Kinetochores - metabolism; Life Sciences; Localization; M Phase Cell Cycle Checkpoints; Maturation; Meiosis; Metaphase; Mice; Mice, Knockout; Microtubules - metabolism; Oocyte; Oocytes; Oocytes - cytology; Oocytes - metabolism; Original; Original Article; Proteins; Proteome; Proteome - metabolism; Proteomes; Proteomics; Spindle Apparatus - metabolism; Spindle assembly; Spindles; Tightening; Spindle assembly; Proteome; Meiosis; Ccdc69; Oocyte

Meiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function is regulated by a complex network of proteins located at spindle and its peripheral region. However, proteome of meiotic spindle remains poo...