Proteome of oocyte spindle identifies Ccdc69 regulates spindle assembly like “band-tightening spell”

Meiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function is regulated by a complex network of proteins located at spindle and its peripheral region. However, proteome of meiotic spindle remains poo...

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Published inCellular and molecular life sciences : CMLS Vol. 82; no. 1; pp. 292 - 20
Main Authors Guo, Jia-Ni, Zhu, Liu, Meng, Tie-Gang, Zhang, Yi-Na, Sun, Si-Min, Yang, Xue-Mei, Zhao, Bing-Wang, Lu, Yi-Ke, Xu, Yuan-Hong, Yue, Wei, Han, Zhiming, Wong, Catherine C. L., Wang, Zhen-Bo
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 30.07.2025
Springer Nature B.V
Springer
Subjects
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Ccdc69
Cell Biology
Cell cycle
Cell division
Chromosomes
Female
Females
Fertility
Gametocytes
Kinases
Kinetochores - metabolism
Life Sciences
Localization
M Phase Cell Cycle Checkpoints
Maturation
Meiosis
Metaphase
Mice
Mice, Knockout
Microtubules - metabolism
Oocyte
Oocytes
Oocytes - cytology
Oocytes - metabolism
Original
Original Article
Proteins
Proteome
Proteome - metabolism
Proteomes
Proteomics
Spindle Apparatus - metabolism
Spindle assembly
Spindles
Tightening
Spindle assembly
Proteome
Meiosis
Ccdc69
Oocyte
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Abstract Meiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function is regulated by a complex network of proteins located at spindle and its peripheral region. However, proteome of meiotic spindle remains poorly characterized. Here, we acquired the proteomic profile of spindles isolated from metaphase I (MI) and metaphase II (MII) mouse oocytes. In particular, we identified Ccdc69 as a novel regulator of spindle assembly in mouse oocytes. Although deletion of Ccdc69 did not affect female fertility, the MI spindles were elongated in Ccdc69 knockout oocytes. Overexpression of Ccdc69 induced spindle defects by reducing microtubule formation and disturbing acentriolar microtubule organization centers (aMTOCs) distribution. Furthermore, Ccdc69 overexpression impaired kinetochore-microtubule (K-MT) attachment and delayed meiotic progression by abnormal activation of spindle assembly checkpoint (SAC). Taken together, our study depicts the proteome of spindles during mouse oocyte maturation and demonstrates that Ccdc69 regulates spindle assembly and meiotic progression the way similar to “The Tightening Spell of Sun Wukong’s Golden Headband” in the famous Chinese Classic Journey to the West .
AbstractList Meiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function is regulated by a complex network of proteins located at spindle and its peripheral region. However, proteome of meiotic spindle remains poorly characterized. Here, we acquired the proteomic profile of spindles isolated from metaphase I (MI) and metaphase II (MII) mouse oocytes. In particular, we identified Ccdc69 as a novel regulator of spindle assembly in mouse oocytes. Although deletion of Ccdc69 did not affect female fertility, the MI spindles were elongated in Ccdc69 knockout oocytes. Overexpression of Ccdc69 induced spindle defects by reducing microtubule formation and disturbing acentriolar microtubule organization centers (aMTOCs) distribution. Furthermore, Ccdc69 overexpression impaired kinetochore-microtubule (K-MT) attachment and delayed meiotic progression by abnormal activation of spindle assembly checkpoint (SAC). Taken together, our study depicts the proteome of spindles during mouse oocyte maturation and demonstrates that Ccdc69 regulates spindle assembly and meiotic progression the way similar to “The Tightening Spell of Sun Wukong’s Golden Headband” in the famous Chinese Classic Journey to the West .
Abstract Meiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function is regulated by a complex network of proteins located at spindle and its peripheral region. However, proteome of meiotic spindle remains poorly characterized. Here, we acquired the proteomic profile of spindles isolated from metaphase I (MI) and metaphase II (MII) mouse oocytes. In particular, we identified Ccdc69 as a novel regulator of spindle assembly in mouse oocytes. Although deletion of Ccdc69 did not affect female fertility, the MI spindles were elongated in Ccdc69 knockout oocytes. Overexpression of Ccdc69 induced spindle defects by reducing microtubule formation and disturbing acentriolar microtubule organization centers (aMTOCs) distribution. Furthermore, Ccdc69 overexpression impaired kinetochore-microtubule (K-MT) attachment and delayed meiotic progression by abnormal activation of spindle assembly checkpoint (SAC). Taken together, our study depicts the proteome of spindles during mouse oocyte maturation and demonstrates that Ccdc69 regulates spindle assembly and meiotic progression the way similar to “The Tightening Spell of Sun Wukong’s Golden Headband” in the famous Chinese Classic Journey to the West.
Meiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function is regulated by a complex network of proteins located at spindle and its peripheral region. However, proteome of meiotic spindle remains poorly characterized. Here, we acquired the proteomic profile of spindles isolated from metaphase I (MI) and metaphase II (MII) mouse oocytes. In particular, we identified Ccdc69 as a novel regulator of spindle assembly in mouse oocytes. Although deletion of Ccdc69 did not affect female fertility, the MI spindles were elongated in Ccdc69 knockout oocytes. Overexpression of Ccdc69 induced spindle defects by reducing microtubule formation and disturbing acentriolar microtubule organization centers (aMTOCs) distribution. Furthermore, Ccdc69 overexpression impaired kinetochore-microtubule (K-MT) attachment and delayed meiotic progression by abnormal activation of spindle assembly checkpoint (SAC). Taken together, our study depicts the proteome of spindles during mouse oocyte maturation and demonstrates that Ccdc69 regulates spindle assembly and meiotic progression the way similar to “The Tightening Spell of Sun Wukong’s Golden Headband” in the famous Chinese Classic Journey to the West .
Meiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function is regulated by a complex network of proteins located at spindle and its peripheral region. However, proteome of meiotic spindle remains poorly characterized. Here, we acquired the proteomic profile of spindles isolated from metaphase I (MI) and metaphase II (MII) mouse oocytes. In particular, we identified Ccdc69 as a novel regulator of spindle assembly in mouse oocytes. Although deletion of Ccdc69 did not affect female fertility, the MI spindles were elongated in Ccdc69 knockout oocytes. Overexpression of Ccdc69 induced spindle defects by reducing microtubule formation and disturbing acentriolar microtubule organization centers (aMTOCs) distribution. Furthermore, Ccdc69 overexpression impaired kinetochore-microtubule (K-MT) attachment and delayed meiotic progression by abnormal activation of spindle assembly checkpoint (SAC). Taken together, our study depicts the proteome of spindles during mouse oocyte maturation and demonstrates that Ccdc69 regulates spindle assembly and meiotic progression the way similar to "The Tightening Spell of Sun Wukong's Golden Headband" in the famous Chinese Classic Journey to the West.Meiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function is regulated by a complex network of proteins located at spindle and its peripheral region. However, proteome of meiotic spindle remains poorly characterized. Here, we acquired the proteomic profile of spindles isolated from metaphase I (MI) and metaphase II (MII) mouse oocytes. In particular, we identified Ccdc69 as a novel regulator of spindle assembly in mouse oocytes. Although deletion of Ccdc69 did not affect female fertility, the MI spindles were elongated in Ccdc69 knockout oocytes. Overexpression of Ccdc69 induced spindle defects by reducing microtubule formation and disturbing acentriolar microtubule organization centers (aMTOCs) distribution. Furthermore, Ccdc69 overexpression impaired kinetochore-microtubule (K-MT) attachment and delayed meiotic progression by abnormal activation of spindle assembly checkpoint (SAC). Taken together, our study depicts the proteome of spindles during mouse oocyte maturation and demonstrates that Ccdc69 regulates spindle assembly and meiotic progression the way similar to "The Tightening Spell of Sun Wukong's Golden Headband" in the famous Chinese Classic Journey to the West.
ArticleNumber 292
Author Sun, Si-Min
Lu, Yi-Ke
Zhang, Yi-Na
Meng, Tie-Gang
Wong, Catherine C. L.
Zhu, Liu
Yue, Wei
Xu, Yuan-Hong
Yang, Xue-Mei
Wang, Zhen-Bo
Zhao, Bing-Wang
Guo, Jia-Ni
Han, Zhiming
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  organization: Department of Medical Research Center, State Key Laboratory for Complex, Severe and Rare Diseases, Clinical Research Institute, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
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  givenname: Xue-Mei
  surname: Yang
  fullname: Yang, Xue-Mei
  organization: State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing Institute for Stem Cell and Regenerative Medicine, University of Chinese Academy of Sciences
– sequence: 7
  givenname: Bing-Wang
  surname: Zhao
  fullname: Zhao, Bing-Wang
  organization: State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing Institute for Stem Cell and Regenerative Medicine, University of Chinese Academy of Sciences
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  givenname: Yi-Ke
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  givenname: Yuan-Hong
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– sequence: 10
  givenname: Wei
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  email: hanzm@ioz.ac.cn
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  givenname: Catherine C. L.
  surname: Wong
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  email: catherine_wong@bjmu.edu.cn
  organization: Department of Medical Research Center, State Key Laboratory for Complex, Severe and Rare Diseases, Clinical Research Institute, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
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  surname: Wang
  fullname: Wang, Zhen-Bo
  email: wangzb@ioz.ac.cn
  organization: State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing Institute for Stem Cell and Regenerative Medicine, University of Chinese Academy of Sciences
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Issue 1
Keywords Spindle assembly
Proteome
Meiosis
Ccdc69
Oocyte
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Snippet Meiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its function...
Abstract Meiotic spindle is an intricate structure and required for chromosome segregation and the proper meiotic progression during oocyte maturation, and its...
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SubjectTerms Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Ccdc69
Cell Biology
Cell cycle
Cell division
Chromosomes
Female
Females
Fertility
Gametocytes
Kinases
Kinetochores - metabolism
Life Sciences
Localization
M Phase Cell Cycle Checkpoints
Maturation
Meiosis
Metaphase
Mice
Mice, Knockout
Microtubules - metabolism
Oocyte
Oocytes
Oocytes - cytology
Oocytes - metabolism
Original
Original Article
Proteins
Proteome
Proteome - metabolism
Proteomes
Proteomics
Spindle Apparatus - metabolism
Spindle assembly
Spindles
Tightening
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Title Proteome of oocyte spindle identifies Ccdc69 regulates spindle assembly like “band-tightening spell”
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