Magnetic Resonance Images Implicate That Glymphatic Alterations Mediate Cognitive Dysfunction in Alzheimer Disease

• Published in: Annals of neurology Vol. 93; no. 1; pp. 164 - 174
• Main Authors: Hsu, Jung‐Lung, Wei, Yi‐Chia, Toh, Cheng Hong, Hsiao, Ing‐Tsung, Lin, Kun‐Ju, Yen, Tzu‐Chen, Liao, Ming‐Feng, Ro, Long‐Sun
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.01.2023; Wiley Subscription Services, Inc
• Subjects: Aged; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid; Amyloid - metabolism; Animal diseases; Biomarkers; Brain; Brain - pathology; Cognitive ability; Cognitive Dysfunction - pathology; Executive function; Female; Genotypes; Humans; Image analysis; Image processing; Magnetic Resonance Imaging; Male; Medical imaging; Middle Aged; Neurodegenerative diseases; Neuroimaging; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Resonance; Sleep deprivation; Substantia grisea; Tau protein; tau Proteins - metabolism; Tensors

Objective The glymphatic system cleans amyloid and tau proteins from the brain in animal studies of Alzheimer disease (AD). However, there is no direct evidence showing this in humans. Methods Participants (n = 50, 62.6 ± 5.4 years old, 36 women) with AD and normal controls underwent amyloid positro...