IFN-γ As an Indicator of Successful Immunization of Goats Vaccinated with a Killed Cowdria ruminantium Vaccine

• Published in: Annals of the New York Academy of Sciences Vol. 969; no. 1; pp. 126 - 130
• Main Authors: ESTEVES, I., BENSAID, A., MARTINEZ, D., TOTTE, P.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2002
• Subjects: Animals; Bacterial Vaccines - immunology; Cattle; Cowdria ruminantium; Dose-Response Relationship, Immunologic; Ehrlichia ruminantium - immunology; Enzyme-Linked Immunosorbent Assay - methods; Enzyme-Linked Immunosorbent Assay - veterinary; gamma interferon; Goat Diseases - microbiology; Goat Diseases - prevention & control; Goats; Heartwater Disease - microbiology; Heartwater Disease - prevention & control; immunization; Interferon-gamma - biosynthesis; Interferon-gamma - blood; Kinetics; Random Allocation; vaccine; Vaccines, Inactivated - immunology

: Cowdria ruminantium‐induced production of IFN‐γ was measured by ELISA on a weekly basis during the course of vaccination with killed organisms emulsified in ISA50. Upon challenge, all (3/3) vaccinated animals that gave the lowest IFN‐γ response died of peracute cowdriosis. On the other hand, only...