Irreversible furin cleavage site exposure renders immature tick-borne flaviviruses fully infectious - Holoubek, Jiří; Salát, Jiří; Matkovic, Milos; Bednář, Petr; Novotný, Pavel; Hradilek, Martin; Majerová, Taťána; Rosendal, Ebba; Eyer, Luděk; Fořtová, Andrea; Beránková, Michaela; Bell-Sakyi, Lesley; et al. (Nature communications, 2025)
Keywords: 13/1; 13/106; 13/51; 14/1; 14/63; 631/326/596/2555; 631/326/596/2557; 64; 64/60; Animals; Aquatic insects; Arachnids; Cleavage; Dengue fever; Dimers; Encephalitis; Encephalitis Viruses, Tick-Borne - genetics; Encephalitis Viruses, Tick-Borne - metabolism; Encephalitis Viruses, Tick-Borne - pathogenicity; Encephalitis Viruses, Tick-Borne - physiology; Endoplasmic reticulum; Experiments; Exposure; Female; Flaviviridae; Flavivirus - genetics; Flavivirus - pathogenicity; Flavivirus - physiology; Furin; Furin - genetics; Furin - metabolism; Genomes; Glycoproteins; Golgi apparatus; Humanities and Social Sciences; Humans; Hydrogen-Ion Concentration; Infections; Infectivity; Maturation; Mice; Mice, Inbred BALB C; Modelling; Molecular dynamics; Mosquitoes; multidisciplinary; pH effects; Phenotypes; Proteins; Proteolysis; Science; Science (multidisciplinary); Site-directed mutagenesis; Tick-borne encephalitis; Vector-borne diseases; Viral Envelope Proteins - chemistry; Viral Envelope Proteins - genetics; Viral Envelope Proteins - metabolism; Virions; Virus Assembly; Viruses; West Nile virus