Plant-derived hydrogel and photosynthetic nano-units for myocardial infarction therapy

Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI). Therefore, addressing both ischemic and reperfusion stages could substantially reduce infarct size and improve clinical outcomes. In this study, we de...

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Published inNature communications Vol. 16; no. 1; pp. 7678 - 15
Main Authors Lv, YongBo, Zhu, Dashuai, Li, Junlang, Li, Yuan, Lu, Chao, Bi, Jianing, Huang, Ke, Hu, Shiqi, Liu, Shuo, Yan, Na, Cheng, Ke, Wang, Juan
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 18.08.2025
Nature Publishing Group
Nature Portfolio
Subjects
13
13/1
13/51
14
14/19
692/308/1426
692/4019/2773
692/699/75/2/1674
Biocompatibility
Cell death
Chloroplasts
Cytotoxicity
Glycyrrhiza
Heart attacks
Humanities and Social Sciences
Hydrogels
Hypoxia
In vivo methods and tests
Injuries
Ischemia
multidisciplinary
Myocardial infarction
Photosynthesis
Plants
Reperfusion
Scanning electron microscopy
Science
Science (multidisciplinary)
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/s41467-025-62020-5

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Abstract Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI). Therefore, addressing both ischemic and reperfusion stages could substantially reduce infarct size and improve clinical outcomes. In this study, we develop a two-component therapeutic system from different parts of Glycyrrhiza : a functional hydrogel made from glycyrrhizic acid extracted from the stem and root, and nanosized chloroplast units (NCUs) derived from leaves. The hydrogel demonstrates therapeutic effects during both hypoxia and reoxygenation stages in vitro, while the photosynthetic NCUs alleviate hypoxia injury by providing ATP and NADPH under illumination. Subsequent in vivo study reveals the most significant therapeutic effect in the combination group (NCU plus hydrogel), which effectively treats both ischemic and reperfusion stages. Our study highlights the cross-species application of plant photosynthetic mechanisms in MI treatment and confirms that simultaneous treatment of ischemia and reperfusion is more effective than treating either stage alone, offering a promising therapeutic strategy for MI. Ischemic injury and reperfusion injury collectively determine total infarct size, a major prognostic factor, following myocardial infarction (MI). Here, Lv et al. develop a hydrogel system utilizing different parts of Glycyrrhiza and apply plant-based photosynthetic mechanisms to treat both ischemic and reperfusion injury in MI.
AbstractList Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI). Therefore, addressing both ischemic and reperfusion stages could substantially reduce infarct size and improve clinical outcomes. In this study, we develop a two-component therapeutic system from different parts of Glycyrrhiza : a functional hydrogel made from glycyrrhizic acid extracted from the stem and root, and nanosized chloroplast units (NCUs) derived from leaves. The hydrogel demonstrates therapeutic effects during both hypoxia and reoxygenation stages in vitro, while the photosynthetic NCUs alleviate hypoxia injury by providing ATP and NADPH under illumination. Subsequent in vivo study reveals the most significant therapeutic effect in the combination group (NCU plus hydrogel), which effectively treats both ischemic and reperfusion stages. Our study highlights the cross-species application of plant photosynthetic mechanisms in MI treatment and confirms that simultaneous treatment of ischemia and reperfusion is more effective than treating either stage alone, offering a promising therapeutic strategy for MI. Ischemic injury and reperfusion injury collectively determine total infarct size, a major prognostic factor, following myocardial infarction (MI). Here, Lv et al. develop a hydrogel system utilizing different parts of Glycyrrhiza and apply plant-based photosynthetic mechanisms to treat both ischemic and reperfusion injury in MI.
Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI). Therefore, addressing both ischemic and reperfusion stages could substantially reduce infarct size and improve clinical outcomes. In this study, we develop a two-component therapeutic system from different parts of Glycyrrhiza: a functional hydrogel made from glycyrrhizic acid extracted from the stem and root, and nanosized chloroplast units (NCUs) derived from leaves. The hydrogel demonstrates therapeutic effects during both hypoxia and reoxygenation stages in vitro, while the photosynthetic NCUs alleviate hypoxia injury by providing ATP and NADPH under illumination. Subsequent in vivo study reveals the most significant therapeutic effect in the combination group (NCU plus hydrogel), which effectively treats both ischemic and reperfusion stages. Our study highlights the cross-species application of plant photosynthetic mechanisms in MI treatment and confirms that simultaneous treatment of ischemia and reperfusion is more effective than treating either stage alone, offering a promising therapeutic strategy for MI.Ischemic injury and reperfusion injury collectively determine total infarct size, a major prognostic factor, following myocardial infarction (MI). Here, Lv et al. develop a hydrogel system utilizing different parts of Glycyrrhiza and apply plant-based photosynthetic mechanisms to treat both ischemic and reperfusion injury in MI.
Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI). Therefore, addressing both ischemic and reperfusion stages could substantially reduce infarct size and improve clinical outcomes. In this study, we develop a two-component therapeutic system from different parts of Glycyrrhiza: a functional hydrogel made from glycyrrhizic acid extracted from the stem and root, and nanosized chloroplast units (NCUs) derived from leaves. The hydrogel demonstrates therapeutic effects during both hypoxia and reoxygenation stages in vitro, while the photosynthetic NCUs alleviate hypoxia injury by providing ATP and NADPH under illumination. Subsequent in vivo study reveals the most significant therapeutic effect in the combination group (NCU plus hydrogel), which effectively treats both ischemic and reperfusion stages. Our study highlights the cross-species application of plant photosynthetic mechanisms in MI treatment and confirms that simultaneous treatment of ischemia and reperfusion is more effective than treating either stage alone, offering a promising therapeutic strategy for MI.Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI). Therefore, addressing both ischemic and reperfusion stages could substantially reduce infarct size and improve clinical outcomes. In this study, we develop a two-component therapeutic system from different parts of Glycyrrhiza: a functional hydrogel made from glycyrrhizic acid extracted from the stem and root, and nanosized chloroplast units (NCUs) derived from leaves. The hydrogel demonstrates therapeutic effects during both hypoxia and reoxygenation stages in vitro, while the photosynthetic NCUs alleviate hypoxia injury by providing ATP and NADPH under illumination. Subsequent in vivo study reveals the most significant therapeutic effect in the combination group (NCU plus hydrogel), which effectively treats both ischemic and reperfusion stages. Our study highlights the cross-species application of plant photosynthetic mechanisms in MI treatment and confirms that simultaneous treatment of ischemia and reperfusion is more effective than treating either stage alone, offering a promising therapeutic strategy for MI.
Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI). Therefore, addressing both ischemic and reperfusion stages could substantially reduce infarct size and improve clinical outcomes. In this study, we develop a two-component therapeutic system from different parts of Glycyrrhiza: a functional hydrogel made from glycyrrhizic acid extracted from the stem and root, and nanosized chloroplast units (NCUs) derived from leaves. The hydrogel demonstrates therapeutic effects during both hypoxia and reoxygenation stages in vitro, while the photosynthetic NCUs alleviate hypoxia injury by providing ATP and NADPH under illumination. Subsequent in vivo study reveals the most significant therapeutic effect in the combination group (NCU plus hydrogel), which effectively treats both ischemic and reperfusion stages. Our study highlights the cross-species application of plant photosynthetic mechanisms in MI treatment and confirms that simultaneous treatment of ischemia and reperfusion is more effective than treating either stage alone, offering a promising therapeutic strategy for MI.
Abstract Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI). Therefore, addressing both ischemic and reperfusion stages could substantially reduce infarct size and improve clinical outcomes. In this study, we develop a two-component therapeutic system from different parts of Glycyrrhiza: a functional hydrogel made from glycyrrhizic acid extracted from the stem and root, and nanosized chloroplast units (NCUs) derived from leaves. The hydrogel demonstrates therapeutic effects during both hypoxia and reoxygenation stages in vitro, while the photosynthetic NCUs alleviate hypoxia injury by providing ATP and NADPH under illumination. Subsequent in vivo study reveals the most significant therapeutic effect in the combination group (NCU plus hydrogel), which effectively treats both ischemic and reperfusion stages. Our study highlights the cross-species application of plant photosynthetic mechanisms in MI treatment and confirms that simultaneous treatment of ischemia and reperfusion is more effective than treating either stage alone, offering a promising therapeutic strategy for MI.
ArticleNumber 7678
Author Li, Yuan
Li, Junlang
Huang, Ke
Hu, Shiqi
Lv, YongBo
Zhu, Dashuai
Bi, Jianing
Lu, Chao
Cheng, Ke
Wang, Juan
Yan, Na
Liu, Shuo
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  organization: Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine
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Snippet Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI)....
Abstract Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI)....
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692/4019/2773
692/699/75/2/1674
Biocompatibility
Cell death
Chloroplasts
Cytotoxicity
Glycyrrhiza
Heart attacks
Humanities and Social Sciences
Hydrogels
Hypoxia
In vivo methods and tests
Injuries
Ischemia
multidisciplinary
Myocardial infarction
Photosynthesis
Plants
Reperfusion
Scanning electron microscopy
Science
Science (multidisciplinary)
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Title Plant-derived hydrogel and photosynthetic nano-units for myocardial infarction therapy
URI https://link.springer.com/article/10.1038/s41467-025-62020-5
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