Toll-like receptor 7/8 agonists stimulate plasmacytoid dendritic cells to initiate TH17-deviated acute contact dermatitis in human subjects

• Published in: Journal of allergy and clinical immunology Vol. 141; no. 4; pp. 1320 - 1333.e11
• Main Authors: Garzorz-Stark, Natalie, Lauffer, Felix, Krause, Linda, Thomas, Jenny, Atenhan, Anne, Franz, Regina, Roenneberg, Sophie, Boehner, Alexander, Jargosch, Manja, Batra, Richa, Mueller, Nikola S., Haak, Stefan, Groß, Christina, Groß, Olaf, Traidl-Hoffmann, Claudia, Theis, Fabian J., Schmidt-Weber, Carsten B., Biedermann, Tilo, Eyerich, Stefanie, Eyerich, Kilian
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.04.2018
• Subjects: Aldara; contact dermatitis; cytotoxicity; IL-23; imiquimod; innate immunity; plasmacytoid dendritic cell; Psoriasis; TH17; Toll-like receptor; ACD; RT; Psoriasis; NOS2; HRP; contact dermatitis; plasmacytoid dendritic cell; ICD; IL-23; pDC; BDCA2; innate immunity; APC; imiquimod; TLR; Aldara; TH17; cytotoxicity; Toll-like receptor

A standardized human model to study early pathogenic events in patients with psoriasis is missing. Activation of Toll-like receptor 7/8 by means of topical application of imiquimod is the most commonly used mouse model of psoriasis. We sought to investigate the potential of a human imiquimod patch t...