Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects

• Published in: Clinical pharmacology and therapeutics Vol. 83; no. 4; p. 595
• Main Authors: Chung, J-Y, Cho, J-Y, Yu, K-S, Kim, J-R, Lim, K S, Sohn, D-R, Shin, S-G, Jang, I-J
• Format: Journal Article
• Language: English
• Published: United States 01.04.2008
• Subjects: Adult; Anticonvulsants - administration & dosage; Anticonvulsants - blood; Anticonvulsants - pharmacokinetics; Anticonvulsants - pharmacology; Area Under Curve; Female; Glucuronosyltransferase - genetics; Humans; Lorazepam - administration & dosage; Lorazepam - blood; Lorazepam - pharmacokinetics; Lorazepam - pharmacology; Male; Polymorphism, Genetic; Psychometrics; Psychomotor Performance - drug effects; Valproic Acid - administration & dosage; Valproic Acid - blood; Valproic Acid - pharmacokinetics; Valproic Acid - pharmacology

Pharmacokinetic and pharmacodynamic profiles of lorazepam and valproate were analyzed according to uridine 5'-diphosphate-glucuronosyltransferase (UGT)2B7 genotype in 14 healthy subjects with UGT2B15*2/*2 genotype. Systemic clearance of lorazepam (2 mg intravenously) and area under the concentr...