Evaluation of ketorolac, aspirin, and an acetaminophen-codeine combination in postoperative oral surgery pain
One-hundred twenty-eight outpatients with postoperative pain after the surgical removal of impacted third molars were randomly assigned, on a double-blind basis, to receive oral doses of ketorolac tromethamine 10 mg, aspirin 650 mg, a combination of acetaminophen 600 mg plus codeine 60 mg, or placeb...
Saved in:
Published in | Pharmacotherapy Vol. 10; no. 6 ( Pt 2); p. 77S |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.01.1990
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | One-hundred twenty-eight outpatients with postoperative pain after the surgical removal of impacted third molars were randomly assigned, on a double-blind basis, to receive oral doses of ketorolac tromethamine 10 mg, aspirin 650 mg, a combination of acetaminophen 600 mg plus codeine 60 mg, or placebo. Using a self-rating record, subjects rated their pain and its relief hourly for 6 hours after medicating. All active medications were significantly superior to placebo. The acetaminophen-codeine combination was significantly superior to aspirin for peak analgesia. Ketorolac was significantly superior to aspirin for every measure of total and peak analgesia, and significantly superior to acetaminophen-codeine for measures of total effect. The analgesic effect of ketorolac was significant by hour 1 and persisted for 6 hours. Repeat-dose data also suggested that ketorolac 10 mg was superior to aspirin 650 mg and acetaminophen-codeine on the day of surgery. Differences among the active medications were trivial for the postoperative days 1-6 analyses. The frequency of adverse effects was over 4 times greater for acetaminophen-codeine than for ketorolac or aspirin. |
---|---|
AbstractList | One-hundred twenty-eight outpatients with postoperative pain after the surgical removal of impacted third molars were randomly assigned, on a double-blind basis, to receive oral doses of ketorolac tromethamine 10 mg, aspirin 650 mg, a combination of acetaminophen 600 mg plus codeine 60 mg, or placebo. Using a self-rating record, subjects rated their pain and its relief hourly for 6 hours after medicating. All active medications were significantly superior to placebo. The acetaminophen-codeine combination was significantly superior to aspirin for peak analgesia. Ketorolac was significantly superior to aspirin for every measure of total and peak analgesia, and significantly superior to acetaminophen-codeine for measures of total effect. The analgesic effect of ketorolac was significant by hour 1 and persisted for 6 hours. Repeat-dose data also suggested that ketorolac 10 mg was superior to aspirin 650 mg and acetaminophen-codeine on the day of surgery. Differences among the active medications were trivial for the postoperative days 1-6 analyses. The frequency of adverse effects was over 4 times greater for acetaminophen-codeine than for ketorolac or aspirin. |
Author | Beaver, W T Burchfield, W H Forbes, J A Butterworth, G A |
Author_xml | – sequence: 1 givenname: J A surname: Forbes fullname: Forbes, J A organization: Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland – sequence: 2 givenname: G A surname: Butterworth fullname: Butterworth, G A – sequence: 3 givenname: W H surname: Burchfield fullname: Burchfield, W H – sequence: 4 givenname: W T surname: Beaver fullname: Beaver, W T |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/2082317$$D View this record in MEDLINE/PubMed |
BookMark | eNotT81qwzAY86Gj67o9wsDsvGS2G9vJcZTuBwq7bOfy2f6yuUts46RlffsF2oOQEJJAN2QWYkBCHjgrOWPiaV_yWsui4bwqedOwcjRsJeuq_JuRBRNaF4yx-prcDMN-ynNViTmZC1aLFdcL0m-O0B1g9DHQ2NJfHGOOHdhHCkPy2YdJBDeBgsUReh9i-sFQ2OjQB6Q29saHc98HmuIwxoR5Mo5IY4aODof8jflEE_hwS65a6Aa8u_CSfL1sPtdvxfbj9X39vC1sxZqqUBKYrqyTrUOutQTNlRLKaFE34MAa65zgIGHVKsZBW2EUb3kL1iEKI8WS3J9308H06HYp-x7yaXe5Lf4BYhtfTg |
CitedBy_id | crossref_primary_10_1046_j_1365_2885_1999_00225_x crossref_primary_10_1111_j_1834_7819_2002_tb00302_x crossref_primary_10_3928_0147_7447_19940201_11 crossref_primary_10_1111_jvp_12044 crossref_primary_10_1002_ddr_21054 crossref_primary_10_1111_j_1527_3458_1996_tb00291_x |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1002/j.1875-9114.1990.tb03584.x |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Pharmacy, Therapeutics, & Pharmacology |
ExternalDocumentID | 2082317 |
Genre | Comparative Study Clinical Trial Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- .GJ .Y3 05W 0R~ 0VX 123 1CY 1OB 1OC 31~ 33P 34G 39C 3SF 4.4 50Z 52U 52V 53G 5RE 8-0 8-1 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AAQQT AASGY AAXRX AAYOK AAZKR ABCUV ABJNI ABLJU ABOCM ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACFBH ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHMBA AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BRXPI CGR CS3 CUY CVF DCZOG DPXWK DRFUL DRMAN DRSTM DU5 EBD EBS ECM EIF EJD EMOBN F5P FEDTE FUBAC G-S GODZA GWYGA H.X HGLYW HVGLF HZ~ J5H KBYEO LATKE LEEKS LH4 LITHE LOXES LSO LUTES LW6 LYRES MEWTI MJL MK0 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM MY~ N04 N05 NF~ NPM O66 O9- P2P P2W PALCI PQQKQ Q.N QB0 R.K RIWAO RJQFR ROL SAMSI SJN SUPJJ SV3 TUS TWZ UDS WBKPD WHWMO WIH WIJ WIK WOHZO WVDHM WXSBR YCJ ZGI ZXP ZZTAW ~WT |
ID | FETCH-LOGICAL-c4094-65a074cd5fde1775a716626b7289adacbcdd21a5a3f601a7c2b61f1facdee2b52 |
ISSN | 0277-0008 |
IngestDate | Sat Sep 28 07:25:05 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 6 ( Pt 2) |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c4094-65a074cd5fde1775a716626b7289adacbcdd21a5a3f601a7c2b61f1facdee2b52 |
PMID | 2082317 |
ParticipantIDs | pubmed_primary_2082317 |
PublicationCentury | 1900 |
PublicationDate | 1990-01-01 |
PublicationDateYYYYMMDD | 1990-01-01 |
PublicationDate_xml | – month: 01 year: 1990 text: 1990-01-01 day: 01 |
PublicationDecade | 1990 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Pharmacotherapy |
PublicationTitleAlternate | Pharmacotherapy |
PublicationYear | 1990 |
SSID | ssj0021642 |
Score | 1.5433661 |
Snippet | One-hundred twenty-eight outpatients with postoperative pain after the surgical removal of impacted third molars were randomly assigned, on a double-blind... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 77S |
SubjectTerms | Acetaminophen - administration & dosage Acetaminophen - therapeutic use Administration, Oral Adolescent Adult Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Aspirin - administration & dosage Aspirin - therapeutic use Codeine - administration & dosage Codeine - therapeutic use Double-Blind Method Drug Administration Schedule Drug Combinations Female Humans Ketorolac Tromethamine Male Pain Measurement Pain, Postoperative - drug therapy Time Factors Tolmetin - administration & dosage Tolmetin - analogs & derivatives Tolmetin - therapeutic use Tooth, Impacted - surgery Tromethamine - administration & dosage Tromethamine - therapeutic use |
Title | Evaluation of ketorolac, aspirin, and an acetaminophen-codeine combination in postoperative oral surgery pain |
URI | https://www.ncbi.nlm.nih.gov/pubmed/2082317 |
Volume | 10 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Na9wwEBWbhkIupU0b-hl0CLnsurUly9oe25A0BBIWsqG5hbE-ILTrNY17SH9Lf2xnLO3aGzalzcHGWGBsz_N4ZjTvibE96VOrwCB4ZYEJirH4zUltE_ACstwJO7ZUhzw9K44v8pNLdTkY_O51Lf1syvfm11peyUOsiufQrsSS_Q_LLi-KJ_AY7Yt7tDDu_8nGh0upbor5vjmSI_gO7ZrlQDPoQR8gyLEOwbgGZtcVCQlUCVHZKcDE28LcGBYtjzXpbNQuyoG37P2bQJwe1hBFumMoO4mi182qLsHR_EcZXM9Jr07aLoe9bEf80h9ZtNG13X4dV-Kzg9hc-jU2cttI1kt7tYngwmiCmMKMFX-b9nBVUCA9nDRDsah8BEeq9flaBx8EY9HBY55FjjonumVK9W2JoVRo_exZvp61phc0nxg4on8dvCO9HUc22IYek_c8o0pQTOYxzWxnqBZP2Anafrj_7rbY43jNO1lMG81Mn7InMQ3hnwKmnrGBq7bZfjTp7YhPO1rezYjv80mncH77nM064PG550vgjXiEHR5UFje-FnS8Bzp-XfEV0HECHY-g4wS6F-zi6HB6cJzEdTsSQ9WCpFCAgamxyluXaa0Ac3LMm0uNyT1YMKWxVmSgQPoizUAbURaZzzwY65woldhhj6p55V4yLseG_jgKciNzkdqPsjTa5gbk2Avh1Su2E17jVR3EWa7i-31938AbttUh9S3b9OgL3DsMLJtyt7XwH_H0dzs |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evaluation+of+ketorolac%2C+aspirin%2C+and+an+acetaminophen-codeine+combination+in+postoperative+oral+surgery+pain&rft.jtitle=Pharmacotherapy&rft.au=Forbes%2C+J+A&rft.au=Butterworth%2C+G+A&rft.au=Burchfield%2C+W+H&rft.au=Beaver%2C+W+T&rft.date=1990-01-01&rft.issn=0277-0008&rft.volume=10&rft.issue=6+%28+Pt+2%29&rft.spage=77S&rft_id=info:doi/10.1002%2Fj.1875-9114.1990.tb03584.x&rft_id=info%3Apmid%2F2082317&rft_id=info%3Apmid%2F2082317&rft.externalDocID=2082317 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0277-0008&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0277-0008&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0277-0008&client=summon |