Long-Term Use of Temozolomide as Safe and Effective Therapy for an Aggressive Corticotroph Adenoma in a Very Old Patient

• Published in: Journal of the Endocrine Society Vol. 5; no. 8; p. bvab065
• Main Authors: Decaroli, Maria Chiara, Ansaloni, Anna, Monzani, Maria Laura, Losa, Marco, Zunarelli, Elena, Rochira, Vincenzo, Madeo, Bruno
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.08.2021
• Subjects: Adenoma; Aged; Cabergoline; Case Report; Corticosteroids; Development and progression; Drug therapy; Gastrointestinal agents; Temozolomide; temozolomide; long-term treatment; aggressive pituitary adenoma; case report; old age

Abstract Background Temozolomide (TMZ) is safe and effective in the treatment of aggressive pituitary adenomas (PAs). However, the optimal duration of TMZ therapy is still unknown. Moreover, data about administration of TMZ in elderly (≥65 years) people to treat aggressive PAs are scarce. We report...