Design and fabrication of drug‐delivery systems toward adjustable release profiles for personalized treatment

Advanced polymeric controlled delivery systems are designed to effectively treat chronic diseases by adjusting the temporal profile of drug release. Most conventional controlled‐release carriers provide a constant and sustained‐release profile of therapeutics for an extended time. Although these sys...

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Published inView (Beijing, China) Vol. 2; no. 5
Main Authors Geraili, Armin, Xing, Malcolm, Mequanint, Kibret
Format Journal Article
LanguageEnglish
Published Beijing John Wiley & Sons, Inc 01.10.2021
Wiley
Subjects
3-D printers
3D printing
adjustable drug release
advanced drug‐delivery systems
Circadian rhythm
Design
Drug administration
Drug delivery systems
Drug dosages
Manufacturing
Mechanical properties
microfabrication
Patient compliance
personalized treatment
Pharmaceuticals
Physicochemical properties
Plasma
polymeric controlled‐release systems
Polymers
Semiconductors
Toxicity
Online AccessGet full text
ISSN2688-3988
2688-268X
2688-268X
DOI10.1002/VIW.20200126

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Abstract Advanced polymeric controlled delivery systems are designed to effectively treat chronic diseases by adjusting the temporal profile of drug release. Most conventional controlled‐release carriers provide a constant and sustained‐release profile of therapeutics for an extended time. Although these systems have improved the patients’ compliance and adherence and have reduced the administration frequency, they cannot be used for optimal treatment of diseases that require variable patterns of drug release in the treatment regimen. These patterns and the specific rhythms of medical conditions determined by both the body's internal biological clock cycles (i.e., circadian rhythm) and each patient's characteristics call for patient‐specific controlled drug‐delivery systems that can provide adjustable drug release profiles. The importance of individualized therapy and the variety of biodegradable polymers with tunable physicochemical properties promote the design and manufacturing of polymeric delivery systems that release therapeutics at controllable rates. In the past two decades, novel biomaterials and fabrication methods have been utilized to improve the traditional drug‐delivery design and manufacturing technologies. This review article provides a critical discussion of emerging polymeric controlled‐release systems and the mechanisms through which they release their therapeutic agents. Advances and challenges in the design and the fabrication processes of polymeric drug‐delivery systems, particularly solid oral dosage forms and implantable microchips, with controllable release profiles of drugs, are reviewed, focusing on the application of microtechnology and 3D printing techniques in their manufacturing. The specific rhythms of medical conditions determined by the body's internal biological clock cycles (i.e., circadian rhythm) and each patient's characteristics call for patient‐specific drug‐delivery systems that can provide adjustable drug release profiles. The importance of individualized therapy and the variety of biodegradable polymers with tunable physicochemical properties promote the design and manufacturing of polymeric delivery systems that release therapeutics at controllable rates. This review article provides a critical discussion of emerging controlled‐release systems and the mechanisms through which they release their therapeutic agents. Advances and challenges in the design and the fabrication processes of drug‐delivery systems, particularly solid oral dosage forms and implantable microchips, with controllable release profiles of drugs, are reviewed, focusing on the application of microtechnology and 3D printing techniques in their manufacturing.
AbstractList Abstract Advanced polymeric controlled delivery systems are designed to effectively treat chronic diseases by adjusting the temporal profile of drug release. Most conventional controlled‐release carriers provide a constant and sustained‐release profile of therapeutics for an extended time. Although these systems have improved the patients’ compliance and adherence and have reduced the administration frequency, they cannot be used for optimal treatment of diseases that require variable patterns of drug release in the treatment regimen. These patterns and the specific rhythms of medical conditions determined by both the body's internal biological clock cycles (i.e., circadian rhythm) and each patient's characteristics call for patient‐specific controlled drug‐delivery systems that can provide adjustable drug release profiles. The importance of individualized therapy and the variety of biodegradable polymers with tunable physicochemical properties promote the design and manufacturing of polymeric delivery systems that release therapeutics at controllable rates. In the past two decades, novel biomaterials and fabrication methods have been utilized to improve the traditional drug‐delivery design and manufacturing technologies. This review article provides a critical discussion of emerging polymeric controlled‐release systems and the mechanisms through which they release their therapeutic agents. Advances and challenges in the design and the fabrication processes of polymeric drug‐delivery systems, particularly solid oral dosage forms and implantable microchips, with controllable release profiles of drugs, are reviewed, focusing on the application of microtechnology and 3D printing techniques in their manufacturing.
Advanced polymeric controlled delivery systems are designed to effectively treat chronic diseases by adjusting the temporal profile of drug release. Most conventional controlled‐release carriers provide a constant and sustained‐release profile of therapeutics for an extended time. Although these systems have improved the patients’ compliance and adherence and have reduced the administration frequency, they cannot be used for optimal treatment of diseases that require variable patterns of drug release in the treatment regimen. These patterns and the specific rhythms of medical conditions determined by both the body's internal biological clock cycles (i.e., circadian rhythm) and each patient's characteristics call for patient‐specific controlled drug‐delivery systems that can provide adjustable drug release profiles. The importance of individualized therapy and the variety of biodegradable polymers with tunable physicochemical properties promote the design and manufacturing of polymeric delivery systems that release therapeutics at controllable rates. In the past two decades, novel biomaterials and fabrication methods have been utilized to improve the traditional drug‐delivery design and manufacturing technologies. This review article provides a critical discussion of emerging polymeric controlled‐release systems and the mechanisms through which they release their therapeutic agents. Advances and challenges in the design and the fabrication processes of polymeric drug‐delivery systems, particularly solid oral dosage forms and implantable microchips, with controllable release profiles of drugs, are reviewed, focusing on the application of microtechnology and 3D printing techniques in their manufacturing. The specific rhythms of medical conditions determined by the body's internal biological clock cycles (i.e., circadian rhythm) and each patient's characteristics call for patient‐specific drug‐delivery systems that can provide adjustable drug release profiles. The importance of individualized therapy and the variety of biodegradable polymers with tunable physicochemical properties promote the design and manufacturing of polymeric delivery systems that release therapeutics at controllable rates. This review article provides a critical discussion of emerging controlled‐release systems and the mechanisms through which they release their therapeutic agents. Advances and challenges in the design and the fabrication processes of drug‐delivery systems, particularly solid oral dosage forms and implantable microchips, with controllable release profiles of drugs, are reviewed, focusing on the application of microtechnology and 3D printing techniques in their manufacturing.
Advanced polymeric controlled delivery systems are designed to effectively treat chronic diseases by adjusting the temporal profile of drug release. Most conventional controlled‐release carriers provide a constant and sustained‐release profile of therapeutics for an extended time. Although these systems have improved the patients’ compliance and adherence and have reduced the administration frequency, they cannot be used for optimal treatment of diseases that require variable patterns of drug release in the treatment regimen. These patterns and the specific rhythms of medical conditions determined by both the body's internal biological clock cycles (i.e., circadian rhythm) and each patient's characteristics call for patient‐specific controlled drug‐delivery systems that can provide adjustable drug release profiles. The importance of individualized therapy and the variety of biodegradable polymers with tunable physicochemical properties promote the design and manufacturing of polymeric delivery systems that release therapeutics at controllable rates. In the past two decades, novel biomaterials and fabrication methods have been utilized to improve the traditional drug‐delivery design and manufacturing technologies. This review article provides a critical discussion of emerging polymeric controlled‐release systems and the mechanisms through which they release their therapeutic agents. Advances and challenges in the design and the fabrication processes of polymeric drug‐delivery systems, particularly solid oral dosage forms and implantable microchips, with controllable release profiles of drugs, are reviewed, focusing on the application of microtechnology and 3D printing techniques in their manufacturing.
Author Xing, Malcolm
Geraili, Armin
Mequanint, Kibret
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  surname: Mequanint
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Snippet Advanced polymeric controlled delivery systems are designed to effectively treat chronic diseases by adjusting the temporal profile of drug release. Most...
Abstract Advanced polymeric controlled delivery systems are designed to effectively treat chronic diseases by adjusting the temporal profile of drug release....
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SubjectTerms 3-D printers
3D printing
adjustable drug release
advanced drug‐delivery systems
Circadian rhythm
Design
Drug administration
Drug delivery systems
Drug dosages
Manufacturing
Mechanical properties
microfabrication
Patient compliance
personalized treatment
Pharmaceuticals
Physicochemical properties
Plasma
polymeric controlled‐release systems
Polymers
Semiconductors
Toxicity
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Title Design and fabrication of drug‐delivery systems toward adjustable release profiles for personalized treatment
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