Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches

• Published in: American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 136B; no. 1; pp. 12 - 25
• Main Authors: Middleton, Frank A., Pato, Carlos N., Gentile, Karen L., McGann, Lindsay, Brown, Andrea M., Trauzzi, Marco, Diab, Heba, Morley, Christopher P., Medeiros, Helena, Macedo, Antonio, Azevedo, M. Helena, Pato, Michele T.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 05.07.2005
• Subjects: Adult; Analysis of Variance; Bipolar Disorder - genetics; Chromosome Mapping; Family Health; Female; Gene Expression Profiling; GeneChip; Genetic Variation; Genomics - methods; Haplotypes; Humans; Leukocytes, Mononuclear - metabolism; Male; microarray; Middle Aged; Oligonucleotide Array Sequence Analysis - methods; Polymorphism, Single Nucleotide; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction - methods; RNA; Schizophrenia - genetics; Siblings; white blood cell

We performed global RNA transcript analysis and comprehensive gene group analysis of peripheral blood leukocyte (PBL) RNA from two groups of matched sib‐pairs that were discordant for either schizophrenia (n = 33 sib‐pairs) or bipolar disorder (n = 5 sib‐pairs). The pairs chosen for these analyses w...