Molecular Characterization of a Group of Proteins Containing Ankyrin Repeats in Orientia tsutsugamushi
: Orientia tsutsugamushi, an obligate intracellular bacterium, is the causative agent of scrub typhus. The sequencing and analysis of full genomic DNA of O. tsutsugamushi has revealed at least 19 genes thus far encoding proteins with different numbers of ankyrin repeat domains. We have cloned severa...
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Published in | Annals of the New York Academy of Sciences Vol. 1063; no. 1; pp. 100 - 101 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.12.2005
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Subjects | |
Online Access | Get full text |
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Summary: | : Orientia tsutsugamushi, an obligate intracellular bacterium, is the causative agent of scrub typhus. The sequencing and analysis of full genomic DNA of O. tsutsugamushi has revealed at least 19 genes thus far encoding proteins with different numbers of ankyrin repeat domains. We have cloned several genes containing ankyrin repeats from the genome and produced fusion proteins to characterize their functions in host cells. It is likely that the proteins with ankyrin repeat domains expressed in O. tsutsugamushi‐infected cells may control the synthesis or stability of host proteins to modulate the various cellular functions after infection. The exploitation of host factors by ankyrin repeat proteins of O. tsutsugamushi may also play a critical role in its pathogenesis. |
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Bibliography: | ark:/67375/WNG-V1B9878V-J istex:E7EBA22FDBA255C70EF84164746808AD25A9360E ArticleID:NYAS100 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0077-8923 1749-6632 |
DOI: | 10.1196/annals.1355.016 |