Perfluorobutane CEUS for early-stage cervical lymphoma: diagnostic value of the postvascular phase starfield sign

• Published in: Scientific reports Vol. 15; no. 1; pp. 28486 - 10
• Main Authors: Liang, Xia, Zeng, Xian-Tao, Hong, Zhi-Liang, Lin, Xiao-Ying, Su, Miao-jiao, Yang, Jian-Chuan, Wu, Song-Song
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.08.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67; 692/4028; Accuracy; Adult; Aged; Benign; Biopsy; Cervical lymphoma; Contrast agents; Contrast Media - administration & dosage; Contrast-enhanced ultrasound; Diagnosis, Differential; Female; Fluorocarbons; Histopathology; Humanities and Social Sciences; Humans; Hyperplasia; Injection; Lymph node; Lymph nodes; Lymph Nodes - diagnostic imaging; Lymph Nodes - pathology; Lymphadenopathy; Lymphatic system; Lymphoma; Lymphoma - diagnostic imaging; Lymphoma - pathology; Male; Middle Aged; multidisciplinary; Neoplasm Staging; Patients; Perflubutane; Postvascular phase; Prospective Studies; ROC Curve; Science; Science (multidisciplinary); Sensitivity and Specificity; Starfield sign; Tuberculosis; Ultrasonic imaging; Ultrasonography - methods; Ultrasound; Uterine Cervical Neoplasms - diagnostic imaging; Uterine Cervical Neoplasms - pathology; United States > US; Cervical lymphoma; Perflubutane; Postvascular phase; Contrast-enhanced ultrasound; Lymph node; Starfield sign

Early differentiation of cervical lymphoma from benign lymphadenopathy remains challenging on conventional imaging. This study assesses the diagnostic efficacy of perfluorobutane contrast-enhanced ultrasound (CEUS) in differentiating early-stage cervical lymphoma from benign lymph nodes (LNs). From...