Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy
Antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further investigated for activity in kindling with pentylenetetrazole and administration of pilocarpine and kainic acid which mimic temporal lobe epilepsy in various anim...
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Published in | BMC research notes Vol. 10; no. 1; p. 167 |
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Abstract | Antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further investigated for activity in kindling with pentylenetetrazole and administration of pilocarpine and kainic acid which mimic temporal lobe epilepsy in various animal species.
ICR mice and Sprague-Dawley rats were pre-treated with AAE (200-800 mg kg
) and convulsive episodes induced using pentylenetetrazole, pilocarpine and kainic acid. The potential of AAE to prevent or delay onset and alter duration of seizures were measured. In addition, damage to hippocampal cells was assessed in kainic acid-induced status epilepticus test. 800 mg kg
of the extract suppressed the kindled seizure significantly (P < 0.05) as did diazepam. AAE also produced significant effect (P < 0.01) on latency to first myoclonic jerks and on total duration of seizures. The latency to onset of wet dog shakes was increased significantly (P < 0.05) by AAE on kainic acid administration. Carbamazepine and Nifedipine (30 mg kg
) also delayed the onset. Histopathological examination of brain sections showed no protective effect on hippocampal cells by AAE and nifedipine. Carbamazepine offered better preservation of hippocampal cells in the CA1, CA2 and CA3 regions.
Antiaris toxicaria may be effective in controlling temporal lobe seizures in rodents. |
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AbstractList | Antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further investigated for activity in kindling with pentylenetetrazole and administration of pilocarpine and kainic acid which mimic temporal lobe epilepsy in various animal species.
ICR mice and Sprague-Dawley rats were pre-treated with AAE (200-800 mg kg
) and convulsive episodes induced using pentylenetetrazole, pilocarpine and kainic acid. The potential of AAE to prevent or delay onset and alter duration of seizures were measured. In addition, damage to hippocampal cells was assessed in kainic acid-induced status epilepticus test. 800 mg kg
of the extract suppressed the kindled seizure significantly (P < 0.05) as did diazepam. AAE also produced significant effect (P < 0.01) on latency to first myoclonic jerks and on total duration of seizures. The latency to onset of wet dog shakes was increased significantly (P < 0.05) by AAE on kainic acid administration. Carbamazepine and Nifedipine (30 mg kg
) also delayed the onset. Histopathological examination of brain sections showed no protective effect on hippocampal cells by AAE and nifedipine. Carbamazepine offered better preservation of hippocampal cells in the CA1, CA2 and CA3 regions.
Antiaris toxicaria may be effective in controlling temporal lobe seizures in rodents. BACKGROUNDAntiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further investigated for activity in kindling with pentylenetetrazole and administration of pilocarpine and kainic acid which mimic temporal lobe epilepsy in various animal species.RESULTSICR mice and Sprague-Dawley rats were pre-treated with AAE (200-800 mg kg-1) and convulsive episodes induced using pentylenetetrazole, pilocarpine and kainic acid. The potential of AAE to prevent or delay onset and alter duration of seizures were measured. In addition, damage to hippocampal cells was assessed in kainic acid-induced status epilepticus test. 800 mg kg-1 of the extract suppressed the kindled seizure significantly (P < 0.05) as did diazepam. AAE also produced significant effect (P < 0.01) on latency to first myoclonic jerks and on total duration of seizures. The latency to onset of wet dog shakes was increased significantly (P < 0.05) by AAE on kainic acid administration. Carbamazepine and Nifedipine (30 mg kg-1) also delayed the onset. Histopathological examination of brain sections showed no protective effect on hippocampal cells by AAE and nifedipine. Carbamazepine offered better preservation of hippocampal cells in the CA1, CA2 and CA3 regions.CONCLUSIONAntiaris toxicaria may be effective in controlling temporal lobe seizures in rodents. Background Antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further investigated for activity in kindling with pentylenetetrazole and administration of pilocarpine and kainic acid which mimic temporal lobe epilepsy in various animal species. Results ICR mice and Sprague-Dawley rats were pre-treated with AAE (200-800 mg kg−1) and convulsive episodes induced using pentylenetetrazole, pilocarpine and kainic acid. The potential of AAE to prevent or delay onset and alter duration of seizures were measured. In addition, damage to hippocampal cells was assessed in kainic acid-induced status epilepticus test. 800 mg kg−1 of the extract suppressed the kindled seizure significantly (P < 0.05) as did diazepam. AAE also produced significant effect (P < 0.01) on latency to first myoclonic jerks and on total duration of seizures. The latency to onset of wet dog shakes was increased significantly (P < 0.05) by AAE on kainic acid administration. Carbamazepine and Nifedipine (30 mg kg−1) also delayed the onset. Histopathological examination of brain sections showed no protective effect on hippocampal cells by AAE and nifedipine. Carbamazepine offered better preservation of hippocampal cells in the CA1, CA2 and CA3 regions. Conclusion Antiaris toxicaria may be effective in controlling temporal lobe seizures in rodents. Abstract Background Antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further investigated for activity in kindling with pentylenetetrazole and administration of pilocarpine and kainic acid which mimic temporal lobe epilepsy in various animal species. Results ICR mice and Sprague–Dawley rats were pre-treated with AAE (200–800 mg kg−1) and convulsive episodes induced using pentylenetetrazole, pilocarpine and kainic acid. The potential of AAE to prevent or delay onset and alter duration of seizures were measured. In addition, damage to hippocampal cells was assessed in kainic acid-induced status epilepticus test. 800 mg kg−1 of the extract suppressed the kindled seizure significantly (P < 0.05) as did diazepam. AAE also produced significant effect (P < 0.01) on latency to first myoclonic jerks and on total duration of seizures. The latency to onset of wet dog shakes was increased significantly (P < 0.05) by AAE on kainic acid administration. Carbamazepine and Nifedipine (30 mg kg−1) also delayed the onset. Histopathological examination of brain sections showed no protective effect on hippocampal cells by AAE and nifedipine. Carbamazepine offered better preservation of hippocampal cells in the CA1, CA2 and CA3 regions. Conclusion Antiaris toxicaria may be effective in controlling temporal lobe seizures in rodents. |
ArticleNumber | 167 |
Author | Mante, Priscilla Kolibea Woode, Eric Adongo, Donatus Wewura |
Author_xml | – sequence: 1 givenname: Priscilla Kolibea surname: Mante fullname: Mante, Priscilla Kolibea email: mantepk@yahoo.co.uk organization: Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. mantepk@yahoo.co.uk – sequence: 2 givenname: Donatus Wewura surname: Adongo fullname: Adongo, Donatus Wewura organization: University of Health and Allied Sciences, Ho, Ghana – sequence: 3 givenname: Eric surname: Woode fullname: Woode, Eric organization: Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana |
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CitedBy_id | crossref_primary_10_1007_s12035_022_03038_4 crossref_primary_10_1016_j_bcab_2019_101155 crossref_primary_10_1038_s41598_019_46715_6 crossref_primary_10_46810_tdfd_1002192 crossref_primary_10_1007_s11011_022_01052_y crossref_primary_10_1177_09731296231203790 |
Cites_doi | 10.1016/0165-0173(89)90003-9 10.1002/0471142301.ns0937s58 10.1016/j.brainresbull.2006.10.005 10.1016/0166-4328(83)90136-5 10.1016/S1734-1140(13)71005-3 10.1016/S0028-3908(00)00103-9 10.1016/B978-012088554-1/50037-2 10.1016/j.neuint.2015.05.003 10.1016/j.pbb.2012.08.025 10.1016/j.yebeh.2015.10.032 10.1016/j.neubiorev.2013.10.011 10.1155/2013/519208 10.1016/B978-0-08-028021-9.50029-0 10.1111/j.1471-4159.2006.03907.x 10.1016/0006-8993(94)91546-6 10.1016/S0014-2999(00)00714-7 10.1016/j.pbb.2004.04.004 10.1016/0306-4522(87)90171-0 10.1016/S0920-1211(02)00213-9 10.1016/S0166-2236(00)01659-3 10.1002/syn.890030207 10.1002/(SICI)1096-9861(19970901)385:3<385::AID-CNE4>3.0.CO;2-# 10.1016/j.pneurobio.2004.03.009 10.1002/ana.410340604 10.1016/j.neulet.2007.04.056 10.1007/s10571-014-0110-5 10.1126/science.7901908 10.1016/j.seizure.2010.02.010 10.1016/0197-0186(95)00064-F 10.1111/j.1471-4159.1992.tb10990.x 10.1007/s00415-012-6727-8 |
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Keywords | Pentylenetetrazole Pilocarpine Kindling Kainic acid Hippocampus |
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Snippet | Antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further investigated for... Background Antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further... BACKGROUNDAntiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further... Abstract Background Antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further... |
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SubjectTerms | Acids Animal models Animals Antiaris - chemistry Antiaris toxicaria Anticonvulsants Anticonvulsants - pharmacology Ascorbic acid Autonomic nervous system Bedding Body weight Brain Brain injury Brain slice preparation Calcium channels (L-type) Carbamazepine Carbamazepine - pharmacology Central nervous system Diazepam - pharmacology Disease Models, Animal Drug Administration Schedule Drug dosages Epilepsy Epilepsy, Temporal Lobe - chemically induced Epilepsy, Temporal Lobe - drug therapy Epilepsy, Temporal Lobe - physiopathology Food Hippocampus Hippocampus - drug effects Hippocampus - physiopathology Hyperactivity Inflammation Kainic acid Kainic Acid - toxicity Kindling Laboratory animals Male Mental disorders Mice Mice, Inbred ICR Neostriatum Neuropeptides Nifedipine - pharmacology Nimodipine Pentylenetetrazole Pentylenetetrazole - toxicity Pilocarpine Pilocarpine - toxicity Plant Extracts - pharmacology Rats Rats, Sprague-Dawley Rodents Seizures Surgery Temperature effects Temporal lobe |
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Title | Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy |
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