Size-selective collection of circulating tumor cells using Vortex technology

• Published in: Lab on a chip Vol. 14; no. 1; pp. 63 - 77
• Main Authors: Sollier, Elodie, Go, Derek E, Che, James, Gossett, Daniel R, O'Byrne, Sean, Weaver, Westbrook M, Kummer, Nicolas, Rettig, Matthew, Goldman, Jonathan, Nickols, Nicholas, McCloskey, Susan, Kulkarni, Rajan P, Di Carlo, Dino
• Format: Journal Article
• Language: English
• Published: England 07.01.2014
• Subjects: Antibodies, Immobilized - chemistry; Antibodies, Immobilized - immunology; Antigens, Neoplasm - immunology; Antigens, Neoplasm - metabolism; Blood; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; Cell Adhesion Molecules - immunology; Cell Adhesion Molecules - metabolism; Cell Separation - instrumentation; Cell Separation - methods; Cell Shape; Cell Size; Circulating; Devices; Epithelial Cell Adhesion Molecule; Female; Fluid dynamics; Fluid flow; Fluorescent Dyes - chemistry; Humans; Leukocytes - chemistry; Leukocytes - metabolism; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; MCF-7 Cells; Microfluidic Analytical Techniques - instrumentation; Microfluidic Analytical Techniques - methods; Neoplastic Cells, Circulating - metabolism; Purity; Vortices

A blood-based, low cost alternative to radiation intensive CT and PET imaging is critically needed for cancer prognosis and management of its treatment. "Liquid biopsies" of circulating tumor cells (CTCs) from a relatively non-invasive blood draw are particularly ideal, as they can be repe...